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Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids (2024)
Patent
Webb, K., Moradi, E., & Foss, A. (2024). Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids. WO2024009101A1. UK

The invention provides a method of delivering a payload molecule across an epithelial tissue barrier, the method comprising: applying the payload molecule to the epithelial tissue barrier, and additionally applying an agent to the epithelial tissue b... Read More about Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids.

U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol (2022)
Journal Article
Hernandez, F. U., Wang, T., Lee, S. W., Norris, A., Liu, L. L., Hayes-Gill, B. R., …Korposh, S. (2022). U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol. Sensors and Actuators B: Chemical, 372, Article 132653. https://doi.org/10.1016/j.snb.2022.132653

Propofol is used widely for intravenous anaesthesia during surgery and sedation in critical care. There is no method currently to assay the concentration of propofol in plasma in real time. The ability to do so would significantly improve patient saf... Read More about U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol.

Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models (2020)
Journal Article
Macdonald, C. M., Arridge, S., & Powell, S. (2020). Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models. Journal of Biomedical Optics, 25(08), https://doi.org/10.1117/1.jbo.25.8.085002

Significance: Indirect imaging problems in biomedical optics generally require repeated evaluation of forward models of radiative transport, for which Monte Carlo is accurate yet computationally costly. We develop an approach to reduce this bottlene... Read More about Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models.

Condenser-free contrast methods for transmitted-light microscopy (2014)
Journal Article
Webb, K. F. (2014). Condenser-free contrast methods for transmitted-light microscopy. Journal of Microscopy, 257(1), 8-22. https://doi.org/10.1111/jmi.12181

Phase contrast microscopy allows the study of highly transparent yet detail-rich specimens by producing intensity contrast from phase objects within the sample. Presented here is a generalized phase contrast illumination schema in which condenser opt... Read More about Condenser-free contrast methods for transmitted-light microscopy.