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Computer-Assisted Stereo-Electroencephalography (SEEG) Planning - Centre-Specific Priors Enhance Planning (2025)
Journal Article
Dasgupta, D., Elliott, C. A., O’Keeffe, A. G., Rodionov, R., Li, K., Vakharia, V. N., Mirza, F. A., Zubair Tahir, M., Tisdall, M. M., Miserocchi, A., McEvoy, A. W., Ourselin, S., Sparks, R. E., & Duncan, J. S. (in press). Computer-Assisted Stereo-Electroencephalography (SEEG) Planning - Centre-Specific Priors Enhance Planning. Frontiers in Neurology,

Objectives
To refine computer-assisted planning (CAP) of SEEG implantations by adding constraints of prior spatial SEEG trajectories (‘Priors’) to improve safety, reduce manual adjustments required, without increasing planning time.

Methods
Retr... Read More about Computer-Assisted Stereo-Electroencephalography (SEEG) Planning - Centre-Specific Priors Enhance Planning.

Kerr metric from two commuting complex structures (2025)
Journal Article
Krasnov, K., & Shaw, A. (in press). Kerr metric from two commuting complex structures. Classical and Quantum Gravity, https://doi.org/10.1088/1361-6382/adb531

The main aim of this paper is to simplify and popularise the construction from the 2013 paper by Apostolov, Calderbank, and Gauduchon, which (among other things) derives the Pleba´nskiPleba´nski-Demia´nskiDemia´nski family of solutions of GR using id... Read More about Kerr metric from two commuting complex structures.

Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial (2025)
Journal Article
Horby, P. W., Emberson, J. R., Thwaites, L., Campbell, M., Peto, L., Pessoa-Amorim, G., Staplin, N., Hamers, R. L., Amuasi, J., Nel, J., Kestelyn, E., Thanh Phong, N., Shrestha, A., Nasronudin, N., Sarkar, R., Ngoc Thach, P., Paudel, D., Sumardi, U., Stewart, R., Nelwan, E., …Landray, M. J. (2025). Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. eClinicalMedicine, 81, Article 103080. https://doi.org/10.1016/j.eclinm.2025.103080

Background
Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not recei... Read More about Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.

Atomic force microscopy (AFM) based microstructural and micromechanical analysis of bitumen during ageing and rejuvenation (2025)
Journal Article
Hu, Y., Yin, Y., Sreeram, A., Si, W., Airey, G. D., Li, B., Singh, B., Özdemir, D. K., & Zhou, L. (2025). Atomic force microscopy (AFM) based microstructural and micromechanical analysis of bitumen during ageing and rejuvenation. Construction and Building Materials, 467, Article 140387. https://doi.org/10.1016/j.conbuildmat.2025.140387

Aging deteriorates the performance of bitumen whereas rejuvenation can partially restore these properties. Although the macroscale properties of bitumen ageing and rejuvenation have been well documented, the microscale mechanisms are still not well u... Read More about Atomic force microscopy (AFM) based microstructural and micromechanical analysis of bitumen during ageing and rejuvenation.

Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats (2025)
Preprint / Working Paper
Renstrom, J. G., Taylor, C. J. L., Grasmeder Allen, R., Loayza, J., O'Hara, L., von Heimendahl, M., Deiana, S., Moran, P. M., Stevenson, C. W., Maggi, S. G., & Bast, T. (2025). Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats

Schizophrenia has been linked to hypofrontality (reduced prefrontal activation) and neural disinhibition (reduced GABAergic inhibition) within the dorsolateral prefrontal cortex (dlPFC), as well as reversal learning deficits. Interestingly, whilst re... Read More about Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats.