Outputs (93)

Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study (2024)
Journal Article
Iyen, B., Coupland, C., Bell, B., Orrell, M., Dening, T., & Avery, T. (2024). Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study. BMJ Medicine, 3(1), Article e000799. https://doi.org/10.1136/bmjmed-2023-000799

Objective To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design Nested case-control study.... Read More about Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

A Qualitative Study of the Views of Ethnic Minority Healthcare Workers Towards COVID-19 Vaccine Education (CoVE) to Support Vaccine Promotion and Uptake (2024)
Journal Article
Blake, H., Premakumar, V., Premakumar, A., Fecowycz, A., Kamkosi Khulumula, S., Jones, W., & Somerset, S. (2024). A Qualitative Study of the Views of Ethnic Minority Healthcare Workers Towards COVID-19 Vaccine Education (CoVE) to Support Vaccine Promotion and Uptake. New Solutions: A Journal of Environmental and Occupational Health Policy, 34(3), 198-212. https://doi.org/10.1177/10482911241273914

Ethnic minority healthcare workers (EMHCW) are at high risk of COVID-19 infection and adverse health outcomes, but vaccine uptake is low among ethnic minority communities, including EMHCW. We explored the views of EMHCW towards COVID-19 Vaccine Educa... Read More about A Qualitative Study of the Views of Ethnic Minority Healthcare Workers Towards COVID-19 Vaccine Education (CoVE) to Support Vaccine Promotion and Uptake.

Menace or Medicine: What to do with Nettles? (2024)
Book Chapter
Connelly, E., & Lee, C. Menace or Medicine: What to do with Nettles?. In Medicine in the Medieval North Atlantic World: Vernacular Texts and Traditions. Brepols Publishers

This paper answers Strabo’s question of 'what to do with nettles' by discussing the worth of nettles in select research outcomes from a project which examined the potential medicinal qualities of nettles (restricted to Urtica dioica) inspired by ear... Read More about Menace or Medicine: What to do with Nettles?.

Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study (2024)
Journal Article
Aldubaybi, A. A., Coneyworth, L. J., & Jethwa, P. H. (2024). Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study. Nutrition Bulletin, 49(1), 96-107. https://doi.org/10.1111/nbu.12662

Food insecurity (FI) among university students in the United States has been associated with poor mental wellbeing, but very little is known about the relationship between FI and mental wellbeing in the UK university population. Here we examined the... Read More about Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study.

Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands (2024)
Journal Article
Chadborn, N. H., Thijssen, M., Logan, P., Radford, K., & Graff, M. (2024). Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands. Health and Social Care in the Community, 2024, Article 5576029. https://doi.org/10.1155/2024/5576029

Introduction. Dementia-friendly communities coordinate activities and events which offer social inclusion and participation of people with dementia. Initiatives can include memory cafés, sports, and tourist and heritage visits. This study explored ho... Read More about Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands.

It was the best of times; it was the worst of times - Health and wellbeing in Nottingham during the 2022 heatwave (2024)
Report
Ogunbode, C., Cooper, E., Prosser, A., Kirkcaldy, H., & Hui, A. (2024). It was the best of times; it was the worst of times - Health and wellbeing in Nottingham during the 2022 heatwave. Nottingham: Nottingham City Council

Previous research provided indications of areas in Nottingham that face higher risks during hot periods based on social and geographical data, but there was little insight into lived experiences of dealing with heat among Nottingham communities. We d... Read More about It was the best of times; it was the worst of times - Health and wellbeing in Nottingham during the 2022 heatwave.

A Multimodal Linguistic Analysis of Gaze and Active Listenership in Emergency Department Team Interactions (2023)
Book Chapter
Atkins, S., & Chałupnik, M. (2023). A Multimodal Linguistic Analysis of Gaze and Active Listenership in Emergency Department Team Interactions. In K. Tsuchiya, F. Coffey, & K. Nakamura (Eds.), Multimodal Approaches to Healthcare Communication Research: Visualizing Interactions for Resilient Healthcare in the UK and Japan (47–64). Bloomsbury Academic. https://doi.org/10.5040/9781350298507.ch-004

Osteoarthritis pain phenotypes: How best to cut the cake? (2023)
Journal Article
Smith, S. L., & Walsh, D. A. (2023). Osteoarthritis pain phenotypes: How best to cut the cake?. Osteoarthritis and Cartilage, Article S1063-4584(23)00986-X. https://doi.org/10.1016/j.joca.2023.11.008

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk (2023)
Journal Article
Lei, C. L., Whittaker, D. G., & Mirams, G. R. (2024). The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk. British Journal of Pharmacology, 181(7), 987-1004. https://doi.org/10.1111/bph.16250

Background and Purpose
Drug-induced reduction of the rapid delayed rectifier potassium current carried by the human Ether-à-go-go-Related Gene (hERG) channel is associated with increased risk of arrhythmias. Recent updates to drug safety regulatory... Read More about The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk.

Mental Health Promotion, Psychological Therapies and Young People's Mental Health (2023)
Book Chapter
Horrocks, M. (2023). Mental Health Promotion, Psychological Therapies and Young People's Mental Health. In The essential guide to public health and health promotion. (Second edition). Routledge

The mental health and well-being of young people is a key consideration for modern societies, and this chapter will focus on mental health promotion for young people. In particular, this chapter will explore the application of Cognitive Behavioural p... Read More about Mental Health Promotion, Psychological Therapies and Young People's Mental Health.

Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers (2023)
Journal Article
Vrettos, N., Wang, P., Wang, Y., Roberts, C. J., Xu, J., Yao, H., & Zhu, Z. (2023). Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers. Pharmaceutical Development and Technology, 28(8), 724-742. https://doi.org/10.1080/10837450.2023.2238822

In the present study, novel gastroretentive bilayer tablets were developed that are promising for the once-a-day oral delivery of the drug candidate MT-1207. The gastroretentive layer consisted of a combination of hydrophilic and hydrophobic polymers... Read More about Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers.

Computational Cardiac Safety Testing (2023)
Book Chapter
Mirams, G. R. (2023). Computational Cardiac Safety Testing. In F. J. Hock, M. R. Gralinski, & M. K. Pugsley (Eds.), Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays (1-33). Springer. https://doi.org/10.1007/978-3-030-73317-9_137-1

In recent years, computational cardiac electrophysiology simulations using mathematical models have begun to be used in industrial and regulatory assessment of the proarrhythmic risk of candidate drug compounds. The aim of this chapter is to equip th... Read More about Computational Cardiac Safety Testing.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., Persson, M. S., Figueredo, G., Layfield, C., & Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction
Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., …Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.

‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020 (2023)
Preprint / Working Paper
Hinsliff-Smith, K., Griffiths, S., Padley, W., De Vries, K., & Brown, J. ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020

When the WHO announced a global pandemic in response to COVID-19, individual countries reacted in a similar way with care homes closing their doors to visits, including visits from family members. The UK was no different, initially they closed to pro... Read More about ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020.

Patient and Public Involvement and Engagement for PhD Students (2023)
Preprint / Working Paper
Gladman, J. R. F., Stocks, J., Phillips, B., Horobin, A., Wragg, A., Mundey, M., Woodcock, R., Braybrooke, R., Junor, A., Hendy, C., Morgan, K., Prior, M., & Humes, D. Patient and Public Involvement and Engagement for PhD Students

This paper aims to provide useful advice regarding the development of skills for patient and public involvement and engagement (PPIE) in research. The authors of this paper comprise experienced PhD supervisors and trainers, researchers leading PPIE a... Read More about Patient and Public Involvement and Engagement for PhD Students.

Effect of deleting four Toxoplasma gondii calcium-binding EGF domain-containing proteins on parasite replication and virulence (2022)
Journal Article
Wang, X.-C., Li, T.-T., Elsheikha, H. M., Zheng, X.-N., Zhao, D.-Y., Wang, J.-L., …Zhu, X.-Q. (2023). Effect of deleting four Toxoplasma gondii calcium-binding EGF domain-containing proteins on parasite replication and virulence. Parasitology Research, 122, 441-450. https://doi.org/10.1007/s00436-022-07739-6

Several calcium-binding proteins including calcium-dependent protein kinases play important roles in several facets of the intracellular infection cycle of the apicomplexan protozoan parasite Toxoplasma gondii. However, the role of the calcium-bindin... Read More about Effect of deleting four Toxoplasma gondii calcium-binding EGF domain-containing proteins on parasite replication and virulence.

Black Skin, White Masks by Frantz Fanon (2022)
Book Chapter
Wright, C. (2022). Black Skin, White Masks by Frantz Fanon. In The Palgrave Handbook of Psychosocial Studies (1-19). Palgrave Macmillan. https://doi.org/10.1007/978-3-030-61510-9_34-1

Black Skin, White Masks, by the experimental psychiatrist and anti-colonial militant, Franz Fanon, is regarded as a seminal text in the fields of postcolonial theory and critical race studies. Yet it has also been deeply influential on – and indeed c... Read More about Black Skin, White Masks by Frantz Fanon.

Returning To Lacan's Seminar XVII (2022)
Book
Litten, R., & Wright, C. (Eds.). (2022). Returning To Lacan's Seminar XVII. New York: Lacanian Press

We now read Jacques Lacan’s seventeenth seminar from “the other side” of a fifty-year gap separating us from its initial delivery, at the Place du Panthéon, in the academic year 1969-1970. This is factually the case, yet viewing it this way is akin t... Read More about Returning To Lacan's Seminar XVII.

Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study (2022)
Journal Article
Andries, E., Bieńkowska, K., Świerniak, W., Skarżyński, P. H., Skarżyński, H., Calvino, M., …Mertens, G. (2022). Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study. Otology and Neurotology, 43(8), e865-e871. https://doi.org/10.1097/MAO.0000000000003622

Purpose To study the evolution of type D personality traits in older adults after cochlear implantation compared with a control group of severely hearing impaired older adults who did not receive a cochlear implant (CI). The influence of COVID-19 on... Read More about Evolution of Type D Personality Traits After Cochlear Implantation in Severely Hearing Impaired Adults 55 Years and Older: An Exploratory Prospective, Longitudinal, Controlled, Multicenter Study.