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Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae (2019)
Journal Article
McWilliams, D. F., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae. BMC Rheumatology, 3, 1-9. https://doi.org/10.1186/s41927-019-0100-9

Background RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete ent... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference
McWilliams, D., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019, April). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae. Poster presented at Rheumatology 2019

Background RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae.

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, 20(6), 716-727. doi:10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More about Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts.

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
Nwosu, L. N., Gowler, P. R., Burston, J. J., Rizoska, B., Tunblad, K., Lindström, E., …Chapman, V. (2018). Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PAIN Reports, 5(6), doi:10.1097/PR9.0000000000000685

Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of cathepsin K, on pain behaviour and joint pathology in a model... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC) (2018)
Conference Proceeding
McWilliams, D. F., Frowd, N., Marshall, L., Stocks, J., Sarmanova, A., Fernandes, G. S., …Walsh, D. A. (2018). Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC)

Background: Knee pain results from a combination of nociceptive input from the joint, and processing by the central nervous system. Pressure pain detection thresholds (PPTs) are lower and pain is more severe in people with greater central sensitisat... Read More about Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., Joharatnam, N., Wilson, D., & Walsh, D. A. (in press). Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatology, 2(8), doi:10.1186/s41927-018-0016-9

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), doi:10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., …Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. doi:10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Discordance between pain and inflammation in rheumatoid arthritis (2018)
Conference Proceeding
McWilliams, D. F. (in press). Discordance between pain and inflammation in rheumatoid arthritis

Recent research interest has focused on the continuing problem of pain in RA. The long term prognosis for pain could be improved, even when inflammation is being suppressed. This talk will describe the progression of pain, and examine how factors oth... Read More about Discordance between pain and inflammation in rheumatoid arthritis.

Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial (2016)
Journal Article
Papou, A., Hussain, S., McWilliams, D. F., Zhang, W., & Doherty, M. (in press). Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. Quality of Life Research, doi:10.1007/s11136-016-1484-2

Purpose. (1) to assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identif... Read More about Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.

Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data (2016)
Journal Article
Kiely, P. D. W., McWilliams, D. F., Ferguson, E., Young, A., Kiely, P. D., & Walsh, D. A. (2016). Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis Research and Therapy, 18(1), https://doi.org/10.1186/s13075-016-1186-8

Background Rheumatoid arthritis (RA) disease activity is often measured using the 28 joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported... Read More about Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17, https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors. Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Erosive and osteoarthritic structural progression in early rheumatoid arthritis (2016)
Journal Article
McWilliams, D. F., Marshall, M., Jayakumar, K., Doherty, S., Doherty, M., Zhang, W., …Walsh, D. A. (2016). Erosive and osteoarthritic structural progression in early rheumatoid arthritis. Rheumatology, 55(8), doi:10.1093/rheumatology/kew197

OBJECTIVES: To investigate factors associated with joint damage in early RA, and how comorbid OA might influence patient assessment and outcomes. METHODS: Baseline radiographs of hands and feet from 512 participants in the Early RA Network cohort, an... Read More about Erosive and osteoarthritic structural progression in early rheumatoid arthritis.

Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study (2012)
Journal Article
McWilliams, D. F., Zhang, W., Mansell, J. S., Kiely, P. D., Young, A., & Walsh, D. A. (2012). Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis Care and Research, 64(10), doi:10.1002/acr.21723

Objective: To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA). Methods: The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year... Read More about Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study.