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The prognostic value of the tumor-stroma ratio is most discriminative in patients with grade III or triple negative breast cancer (2019)
Journal Article
Vangangelt, K. M., Green, A. R., Heemskerk, I. (. F., Cohen, D., Van Pelt, G. W., Sobral-Leite, M., …Mesker, W. E. (in press). The prognostic value of the tumor-stroma ratio is most discriminative in patients with grade III or triple negative breast cancer. International Journal of Cancer,

The tumor-stroma ratio (TSR) was evaluated as a promising parameter for breast cancer prognostication in clinically relevant subgroups of patients. The TSR was assessed on hematoxylin and eosin stained tissue slides of 1794 breast cancer patients fro... Read More about The prognostic value of the tumor-stroma ratio is most discriminative in patients with grade III or triple negative breast cancer.

Prognostic Significance of Nucleolar Assessment in Invasive Breast Cancer (2019)
Journal Article
Elsharawy, K. A., Toss, M. S., Raaft, S. R., Ball, G., Green, A. R., Aleskandarany, M. A., …Rakha, E. A. (2019). Prognostic Significance of Nucleolar Assessment in Invasive Breast Cancer. Histopathology, https://doi.org/10.1111/his.14036

Aims: Nucleolar morphometric features have a potential role in the assessment of aggressiveness of many cancers. However, the role of nucleoli in invasive breast cancer (IBC) is still unclear. This study aimed to investigate the optimal scoring metho... Read More about Prognostic Significance of Nucleolar Assessment in Invasive Breast Cancer.

Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer (2019)
Journal Article
Kurozumi, S., Alsaeed, S., Orah, N., Miligy, I. M., Joseph, C., Aljohani, A., …Rakha, E. A. (2019). Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05488-2

PURPOSE: The epithelial–mesenchymal transition (EMT) plays a key role in breast cancer progression and metastasis. Lipocalin 2 (LCN2) is involved in the regulation of EMT. The aim of this study was to investigate the clinicopathological significance... Read More about Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer.

Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer (2019)
Journal Article
Kariri, Y. A., Joseph, C., Kurozumi, S., Toss, M. S., Alsaleem, M., Raafat, S., …Rakha, E. A. (2019). Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05466-8

Background: KN Motif and Ankyrin Repeat Domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progression of a variety of solid tumo... Read More about Prognostic Significance of KN Motif and Ankyrin Repeat Domains 1 (KANK1) in Invasive Breast Cancer.

The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer (2019)
Journal Article
Aljohani, A. I., Toss, M. S., Kurozumi, S., Joseph, C., Aleskandarany, M. A., Miligy, I. M., …Rakha, E. (2019). The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05459-7

Background: Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significanc... Read More about The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer.

The Role Of Glutaminase In Cancer (2019)
Journal Article
Masisi, B., El Ansari, R., Alfarsi, L., Rakha, E., Green, A., & Craze, M. (2019). The Role Of Glutaminase In Cancer. Histopathology, https://doi.org/10.1111/his.14014

Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. As a heterogeneous disease with different morpholog- ical and molecular subtypes and response to therapy, breast canc... Read More about The Role Of Glutaminase In Cancer.

The intra-tumoral stroma in patients with breast cancer increases with age (2019)
Journal Article
Vangangelt, K., Kramer, C., Bastiaannet, E., Putter, H., Cohen, D., Van Pelt, G., …Mesker, W. (2019). The intra-tumoral stroma in patients with breast cancer increases with age. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05422-6

Purpose The tumor microenvironment in older patients is subject to changes. The tumor-stroma ratio (TSR) was evaluated in order to estimate the amount of intra-tumoral stroma and to evaluate the prognostic value of the TSR in older patients with br... Read More about The intra-tumoral stroma in patients with breast cancer increases with age.

Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer (2019)
Journal Article
Zilio, S., Gee, J. M. W., Ellis, I. O., Green, A. R., Finlay, P., Gobbato, A., & Taylor, K. M. (2019). Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer. Metallomics, https://doi.org/10.1039/C9MT00136K

ZIP7, a member of the ZIP family of zinc importers, resides on the endoplasmic reticulum membrane and transports zinc from intracellular stores to the cytoplasm after activation by CK2 phosphorylation on two serine residues (S275 and S276). ZIP7 is k... Read More about Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer.

The prognostic significance of Cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Mittal, K., Green, A. R., Aneja, R., …Rakha, E. A. (2019). The prognostic significance of Cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology, doi:10.1136/jclinpath-2019-205939

Aims: Cathepsin V (CTSV/CTSL2) is a lysosomal cystine proteinase and plays a role in extracellular matrix degradation. It is associated with poor prognosis in invasive breast cancer (IBC), but its role in breast ductal carcinoma in situ (DCIS) remain... Read More about The prognostic significance of Cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.

Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients (2019)
Journal Article
Mohammed, R. A. A., El-Deek, H. E. M., Aleskandarany, M. A., Green, A. R., Ellis, I. O., & Rakha, E. A. (in press). Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients. Egyptian Journal of Pathology,

Background and aims: Clinicopathological features of Basal-like Breast Cancer (BLBC) in African American women have been extensively studied. Comparatively, less is known about these tumors in patients from countries in the North African region. The... Read More about Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients.

Machine learning-based prediction of breast cancer growth rate in-vivo (2019)
Journal Article
Bhattarai, S., Klimov, S., Aleskandarany, M. A., Burrell, H., Wormall, A., Green, A. R., …Aneja, R. (2019). Machine learning-based prediction of breast cancer growth rate in-vivo. British Journal of Cancer, 121, 497–504. https://doi.org/10.1038/s41416-019-0539-x

Background Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the r... Read More about Machine learning-based prediction of breast cancer growth rate in-vivo.

Surgical management of ductal carcinoma in situ of the breast: a large retrospective study from a single institution (2019)
Journal Article
Miligy, I. M., Toss, M. S., Khout, H., Hc, B., Ellis, I. O., Green, A. R., …Rakha, E. (2019). Surgical management of ductal carcinoma in situ of the breast: a large retrospective study from a single institution. Breast Journal, doi:10.1111/tbj.13425

Background: Management of breast ductal carcinoma in situ (DCIS) has various approaches with distinct institutional specific practice. Here, we review DCIS management in a single institution with emphasise on re-operation rates and outcome. Methods:... Read More about Surgical management of ductal carcinoma in situ of the breast: a large retrospective study from a single institution.

Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer (2019)
Journal Article
Bhattarai, S., Klimov, S., Mittal, K., Krishnamurti, U., Li, B., Oprea-Ilies, G., …Aneja, R. (in press). Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer. Cancers,

Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some st... Read More about Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer.

Enhanced glutamine uptake influence composition of immune cells infiltrates in breast cancer (2019)
Journal Article
Ansari, R. E., Craze, M. L., Althobiti, M., Alfarsi, L., Ellis, I. O., Rakha, E. A., & Green, A. R. (in press). Enhanced glutamine uptake influence composition of immune cells infiltrates in breast cancer. British Journal of Cancer,

Background: Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study aimed to find whether enhanced glutamine uptake in breast cancer (BC) can derive the existenc... Read More about Enhanced glutamine uptake influence composition of immune cells infiltrates in breast cancer.

Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Alkawaz, A., Mittal, K., Aneja, R., …Rakha, E. A. (2019). Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study. Modern Pathology, 32, 1473-1485. https://doi.org/10.1038/s41379-019-0296-7

Collagen plays a key role in normal and malignant tissue homeostasis. While the prognostic significance of collagen fibre remodeling in invasive breast cancer has been studied, its role in ductal carcinoma in situ (DCIS) remains poorly defined. Using... Read More about Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study.

Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Aleskandarany, M. A., Alkawaz, A., Mittal, K., …Rakha, E. A. (2019). Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ. Modern Pathology,

Collagen11A1 (COL11A1) is a fibrillary type collagen constituting a minor component of the extracellular matrix and plays role in tissue tensile strength. Overexpression of COL11A1 expression is associated with aggressive behavior and poor outcome in... Read More about Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ.

A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer (2019)
Journal Article
Kurozumi, S., Joseph, C., Alsaeed, S., Kariri, Y., Aljohani, A., Raafat, S., …Rakha, E. A. (2019). A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer. British Journal of Cancer, 120, 1129–1136. doi:10.1038/s41416-019-0486-6

Background: Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, usin... Read More about A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer.