The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer

Masisi, Brendah K.; El Ansari, Rokaya; Alfarsi, Lutfi; Craze, Madeleine L.; Jewa, Natasha; Oldfield, Andrew; Cheung, Hayley; Toss, Michael; Rakha, Emad A.; Green, Andrew R.

Abstract

Glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aimed to evaluate the expression and prognostic significance of glutaminase in luminal breast cancer (BC). The glutaminase isoforms (GLS/GLS2) were assessed at genomic/transcriptomic levels, using METABRIC (n=1 398) and GeneMiner datasets (n=4 712), and protein using immunohistochemistry in well characterised cohorts of Oestrogen Receptor-positive/HER2-negative BC patients: ductal carcinoma in situ (DCIS; n=206) and invasive breast cancer (IBC; n=717). Glutaminase expression was associated with clinicopathological features, patient outcome and glutamine-metabolism related genes. In DCIS, GLS alone and GLS+/GLS2- expression was a risk factor for shorter local recurrence-free interval (p

Citation

Masisi, B. K., El Ansari, R., Alfarsi, L., Craze, M. L., Jewa, N., Oldfield, A., Cheung, H., Toss, M., Rakha, E. A., & Green, A. R. (2021). The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer. Cancers, 13(16), Article 3963. https://doi.org/10.3390/cancers13163963

• Journal Article Type: Article
• Acceptance Date: Aug 2, 2021
• Online Publication Date: Aug 6, 2021
• Publication Date: Aug 6, 2021
• Deposit Date: Aug 2, 2021
• Publicly Available Date: Aug 2, 2021
• Journal: Cancers
• Electronic ISSN: 2072-6694
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 16
• Article Number: 3963
• DOI: https://doi.org/10.3390/cancers13163963
• Keywords: Cancer Research; Oncology
• Public URL: https://nottingham-repository.worktribe.com/output/5951176
• Publisher URL: https://www.mdpi.com/2072-6694/13/16/3963