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The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer

Masisi, Brendah K.; El Ansari, Rokaya; Alfarsi, Lutfi; Craze, Madeleine L.; Jewa, Natasha; Oldfield, Andrew; Cheung, Hayley; Toss, Michael; Rakha, Emad A.; Green, Andrew R.

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Authors

Brendah K. Masisi

Rokaya El Ansari

Lutfi Alfarsi

Madeleine L. Craze

Natasha Jewa

Andrew Oldfield

Hayley Cheung

Michael Toss

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology



Abstract

Glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aimed to evaluate the expression and prognostic significance of glutaminase in luminal breast cancer (BC). The glutaminase isoforms (GLS/GLS2) were assessed at genomic/transcriptomic levels, using METABRIC (n=1 398) and GeneMiner datasets (n=4 712), and protein using immunohistochemistry in well characterised cohorts of Oestrogen Receptor-positive/HER2-negative BC patients: ductal carcinoma in situ (DCIS; n=206) and invasive breast cancer (IBC; n=717). Glutaminase expression was associated with clinicopathological features, patient outcome and glutamine-metabolism related genes. In DCIS, GLS alone and GLS+/GLS2- expression was a risk factor for shorter local recurrence-free interval (p

Citation

Masisi, B. K., El Ansari, R., Alfarsi, L., Craze, M. L., Jewa, N., Oldfield, A., …Green, A. R. (2021). The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer. Cancers, 13(16), Article 3963. https://doi.org/10.3390/cancers13163963

Journal Article Type Article
Acceptance Date Aug 2, 2021
Online Publication Date Aug 6, 2021
Publication Date Aug 6, 2021
Deposit Date Aug 2, 2021
Publicly Available Date Mar 29, 2024
Journal Cancers
Electronic ISSN 2072-6694
Publisher MDPI AG
Peer Reviewed Peer Reviewed
Volume 13
Issue 16
Article Number 3963
DOI https://doi.org/10.3390/cancers13163963
Keywords Cancer Research; Oncology
Public URL https://nottingham-repository.worktribe.com/output/5951176
Publisher URL https://www.mdpi.com/2072-6694/13/16/3963

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