Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids

Webb, Kevin; Moradi, Emilia; Foss, Alexander

Abstract

The invention provides a method of delivering a payload molecule across an epithelial tissue barrier, the method comprising: applying the payload molecule to the epithelial tissue barrier, and additionally applying an agent to the epithelial tissue barrier. The agent is (i) a microbial quorum sensing signalling molecule (microbial QSSM) or a derivative or variant thereof, which is capable of disrupting the epithelial tissue barrier function, or (ii) a carboxylic acid compound, or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Citation

Webb, K., Moradi, E., & Foss, A. (2024). Disruption of Epithelial Barriers for Molecular Delivery Enhancement or Extraction of Extracellular Fluids. WO2024009101A1. UK

• Online Publication Date: Jan 11, 2024
• Publication Date: Jan 11, 2024
• Deposit Date: Jul 6, 2022
• Public URL: https://nottingham-repository.worktribe.com/output/8853266
• Related Public URLs: https://worldwide.espacenet.com/patent/search/family/082802529/publication/WO2024009101A1?q=pn%3DWO2024009101A1