Research Repository

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Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review (2019)
Journal Article
Chadborn, N., Goodman, C., Zubair, M., Sousa, L., Gladman, J., Dening, T., & Gordon, A. (2019). Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review. BMJ Open, 9(4), doi:10.1136/bmjopen-2018-026921

Objectives Comprehensive Geriatric Assessment (CGA) may be a way to deliver optimal care for care home residents. We used realist review to develop a theory-driven account of how CGA works in care homes. Design Realist review Setting Care ho... Read More

Tactical authenticity in the production of mad narratives (2019)
Journal Article
WRIGHT, C., & CLARKE, S. (2019). Tactical authenticity in the production of mad narratives. Social Theory and Health, 17(2), 15. doi:10.1057/s41285-019-00092-2

First-person accounts of madness and of encountering psychiatric services provide important sociocultural and psychological knowledge about the subjectivity of distress. The importance of such accounts is often based upon a claim of the authenticity... Read More

Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? (2019)
Journal Article
Morandi, E., Tanasescu, R., Tarlington, R., Constantin-Teodosiu, D., & Gran, B. (2019). Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus?. Frontiers in Immunology, 9, doi:10.3389/fimmu.2018.03092

The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progres... Read More

Discrimination of gain increments in speech-shaped noises (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. (2019). Discrimination of gain increments in speech-shaped noises. Trends in Hearing, 23, 1-12. doi:10.1177/2331216518820220

Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To... Read More

Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes (2019)
Journal Article
Izquierdo, A., Fahrenberger, M., Persampieri, T., Benedict, M. Q., Giles, T., Catteruccia, F., …Dottorini, T. (2019). Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes. Life Science Alliance, 2(1), doi:10.26508/lsa.201800191

Modifications in gene expression determine many of the phenotypic differentiations between closely related species. This is particularly evident in reproductive tissues, where evolution of genes is more rapid, facilitating the appearance of distinct... Read More

Improving community support for older people’s needs through commissioning third sector services: a qualitative study (2018)
Journal Article
Chadborn, N., Craig, C., Sands, G., Schneider, J., & Gladman, J. (in press). Improving community support for older people’s needs through commissioning third sector services: a qualitative study. Journal of Health Services Research and Policy,

Aim: This exploratory study of commissioning third sector services for older people aimed to explore whether service data was fed back to commissioners and whether this could improve intelligence about the population and hence inform future commissio... Read More

The broiler chicken as a signal of a human reconfigured biosphere (2018)
Journal Article
Bennett, C. E., Thomas, R., Williams, M., Zalasiewicz, J., Edgeworth, M., Miller, H., …Marume, U. (2018). The broiler chicken as a signal of a human reconfigured biosphere. Royal Society Open Science, 5(12), doi:10.1098/rsos.180325

Changing patterns of human resource use and food consumption have profoundly impacted the Earth’s biosphere. Until now, no individual taxa have been suggested as distinct and characteristic new morphospecies representing this change. Here we show tha... Read More

Engaging and developing the frontline clinical nurse to drive care excellence: evaluating the Chief Nurse Junior Excellence in Care Fellowship Initiative (2018)
Journal Article
Bramley, L., Manning, J., & Cooper, J. (2018). Engaging and developing the frontline clinical nurse to drive care excellence: evaluating the Chief Nurse Junior Excellence in Care Fellowship Initiative. International Journal of Research in Nursing, 16(12), 1977-1990. doi:10.1177/1744987118808843

Background Global challenges in the development of a highly skilled and motivated nursing workforce, jeopardises the delivery of high quality care. Flexible and innovative workforce solutions are required to overcome these challenges. Aims... Read More

Parents’ and carers’ experiences of transition and aftercare following a child’s discharge from a Pediatric Intensive Care Unit to an in-patient ward setting: a qualitative systematic review (2018)
Journal Article
Suleman, Z., Evans, C., & Manning, J. (2019). Parents’ and carers’ experiences of transition and aftercare following a child’s discharge from a Pediatric Intensive Care Unit to an in-patient ward setting: a qualitative systematic review. Intensive and Critical Care Nursing, 55, 35-44. doi:10.1016/j.iccn.2018.10.003

Objectives: To explore parents’ experiences of transition and aftercare following their child’s discharge from a pediatric intensive care unit to an inpatient ward. Methods: A qualitative systematic review was conducted. Electronic databases CINAHL,... Read More

Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii (2018)
Journal Article
Wang, M., Zhang, F., Elsheikha, H. M., Zhang, N., He, J., Luo, J., & Zhu, X. (2018). Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasites and Vectors, 11(1), doi:10.1186/s13071-018-3179-8

Background: Although sexual reproduction of the parasite Toxoplasma gondii exclusively occurs in the cat intestine, knowledge about the alteration of gene expression in the intestine of cats infected with T. gondii is still limited. Here, we investig... Read More

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists (2018)
Journal Article
Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano, C. P., …Leurs, R. (2019). Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. European Journal of Medicinal Chemistry, 162, 631-649. doi:10.1016/j.ejmech.2018.10.060

Using the available structural information of the chemokine receptor CXCR4, we present hit finding and hit exploration studies that make use of virtual fragment screening, design, synthesis and structure-activity relationship (SAR) studies. Fragment... Read More

Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity? (2018)
Journal Article
Rowland, S. C., Hartley, D. E. H., & Wiggins, I. M. (2018). Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?. Trends in Hearing, 22, (1-18). doi:10.1177/2331216518804116. ISSN 2331-2165

Listening to speech in the noisy conditions of everyday life can be effortful, reflecting the increased cognitive workload involved in extracting meaning from a degraded acoustic signal. Studying the underlying neural processes has the potential to p... Read More

Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS) (2018)
Journal Article
Lawrence, R. J., Wiggins, I. M., Anderson, C. A., Davies-Thompson, J., & Hartley, D. E. (2018). Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS). Hearing Research, 370, 53-64. doi:10.1016/j.heares.2018.09.005

Functional neuroimaging has identified that the temporal, frontal and parietal cortex support core aspects of speech processing. An objective measure of speech intelligibility based on cortical activation in these brain regions would be extremely use... Read More

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis (2018)
Journal Article
Mbanefo, E. C., Le, L., Pennington, L. F., Odegaard, J. I., Jardetzky, T. S., Alouffi, A., …Hsieh, M. H. (2018). Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. FASEB Journal, 32(8), (4408-4419). doi:10.1096/fj.201701415r. ISSN 0892-6638

Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized th... Read More

Lacan's cybernetic theory of causality: repetition and the unconscious in Duncan Jones' Source Code (2018)
Book Chapter
Wright, C. (2018). Lacan's cybernetic theory of causality: repetition and the unconscious in Duncan Jones' Source Code. In S. Matviyenko, & J. Roof (Eds.), Lacan and the Posthuman, 67-88. Palgrave Macmillan. doi:10.1007/978-3-319-76327-9_5

This chapter explores the intersections between the fields of Lacanian psychoanalysis and theories of the posthuman. It argues that Lacan's early engagements with cybernetics and game theory prefigured many of the questions about artificial intellige... Read More

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), doi:10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More

Proportionate methods for evaluating a simple digital mental health tool (2017)
Journal Article
Davies, E. B., Craven, M. P., Martin, J. L., & Simons, L. (2017). Proportionate methods for evaluating a simple digital mental health tool. Evidence-Based Mental Health, 20(4), 112-117. doi:10.1136/eb-2017-102755

Background: Traditional evaluation methods are not keeping pace with rapid developments in mobile health. More flexible methodologies are needed to evaluate mHealth technologies, particularly simple, self-help tools. One approach is to combine a var... Read More

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, doi:10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. doi:10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), doi:10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More