Research Repository

See what's under the surface


Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? (2019)
Journal Article
Morandi, E., Tanasescu, R., Tarlington, R., Constantin-Teodosiu, D., & Gran, B. (2019). Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus?. Frontiers in Immunology, 9, doi:10.3389/fimmu.2018.03092

The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progres... Read More

Improving community support for older people’s needs through commissioning third sector services: a qualitative study (2018)
Journal Article
Chadborn, N., Craig, C., Sands, G., Schneider, J., & Gladman, J. (in press). Improving community support for older people’s needs through commissioning third sector services: a qualitative study. Journal of Health Services Research and Policy,

Aim: This exploratory study of commissioning third sector services for older people aimed to explore whether service data was fed back to commissioners and whether this could improve intelligence about the population and hence inform future commissio... Read More

The broiler chicken as a signal of a human reconfigured biosphere (2018)
Journal Article
Bennett, C. E., Thomas, R., Williams, M., Zalasiewicz, J., Edgeworth, M., Miller, H., …Marume, U. (2018). The broiler chicken as a signal of a human reconfigured biosphere. Royal Society Open Science, 5(12), doi:10.1098/rsos.180325

Changing patterns of human resource use and food consumption have profoundly impacted the Earth’s biosphere. Until now, no individual taxa have been suggested as distinct and characteristic new morphospecies representing this change. Here we show tha... Read More

Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii (2018)
Journal Article
Wang, M., Zhang, F., Elsheikha, H. M., Zhang, N., He, J., Luo, J., & Zhu, X. (2018). Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasites and Vectors, 11(1), doi:10.1186/s13071-018-3179-8

Background: Although sexual reproduction of the parasite Toxoplasma gondii exclusively occurs in the cat intestine, knowledge about the alteration of gene expression in the intestine of cats infected with T. gondii is still limited. Here, we investig... Read More

Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS) (2018)
Journal Article
Lawrence, R. J., Wiggins, I. M., Anderson, C. A., Davies-Thompson, J., & Hartley, D. E. (2018). Cortical correlates of speech intelligibility measured using functional near-infrared spectroscopy (fNIRS). Hearing Research, 370, 53-64. doi:10.1016/j.heares.2018.09.005

Functional neuroimaging has identified that the temporal, frontal and parietal cortex support core aspects of speech processing. An objective measure of speech intelligibility based on cortical activation in these brain regions would be extremely use... Read More

Lacan's cybernetic theory of causality: repetition and the unconscious in Duncan Jones' Source Code (2018)
Book Chapter
Wright, C. (2018). Lacan's cybernetic theory of causality: repetition and the unconscious in Duncan Jones' Source Code. In S. Matviyenko, & J. Roof (Eds.), Lacan and the Posthuman, 67-88. Palgrave Macmillan. doi:10.1007/978-3-319-76327-9_5

This chapter explores the intersections between the fields of Lacanian psychoanalysis and theories of the posthuman. It argues that Lacan's early engagements with cybernetics and game theory prefigured many of the questions about artificial intellige... Read More

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), doi:10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More

Proportionate methods for evaluating a simple digital mental health tool (2017)
Journal Article
Davies, E. B., Craven, M. P., Martin, J. L., & Simons, L. (2017). Proportionate methods for evaluating a simple digital mental health tool. Evidence-Based Mental Health, 20(4), 112-117. doi:10.1136/eb-2017-102755

Background: Traditional evaluation methods are not keeping pace with rapid developments in mobile health. More flexible methodologies are needed to evaluate mHealth technologies, particularly simple, self-help tools. One approach is to combine a var... Read More

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, doi:10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. doi:10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), doi:10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More

Proteomic profiling of mouse liver following acute Toxoplasma gondii infection (2016)
Journal Article
He, J., Ma, J., Elsheikha, H. M., Song, H., Zhou, D., & Zhu, X. (2016). Proteomic profiling of mouse liver following acute Toxoplasma gondii infection. PLoS ONE, 11(3), 1-15. doi:10.1371/journal.pone.0152022

Toxoplasma gondii remains a global public health problem. However, its pathophysiology is still not-completely understood particularly the impact of infection on host liver metabolism. We performed iTRAQ-based proteomic analysis to evaluate early liv... Read More

Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow (2016)
Journal Article
Miftakhova, R., Hedblom, A., Semenas, J., Robinson, B. D., Simoulis, A., Malm, J., …Persson, J. L. (2016). Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. Cancer Research, 76(8), doi:10.1158/0008-5472.CAN-15-2340

Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain... Read More

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), doi:10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More