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Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial (2019)
Journal Article
Appleton, J., Blair, G. W., Flaherty, K., Law, Z., May, J., Woodhouse, L. J., …Wardlow, J. M. (2019). Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial. Frontiers in Neurology, 10, 1-6. https://doi.org/10.3389/fneur.2019.00723

Background Cilostazol and isosorbide mononitrate (ISMN) are candidate treatments for cerebral small vessel disease and lacunar ischaemic stroke. As both drugs may influence haemoglobin and platelet count, and haemodynamics, we sought to assess their... Read More

Weniger ist manchmal mehr! (2019)
Journal Article
Bast, T. (2019). Weniger ist manchmal mehr!. Gehirn und Geist, 8/2019, 46-51

HIRNFORSCHUNG NEURONALE HEMMUNG Lange Zeit dachten Forscher, dass viele neurologische und psychiatrische Erkrankungen auf einer zu geringen Hirnaktivität beruhen. Doch häufig ist genau das Gegenteil der Fall.

Antidepressants for treating depression in dementia (2018)
Journal Article
Dudas, R., Malouf, R., McCleery, J., & Dening, T. (2018). Antidepressants for treating depression in dementia. Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD003944.pub2

Background The use of antidepressants in dementia accompanied by depressive symptoms is widespread, but their clinical efficacy is uncertain. This review updates an earlier version, first published in 2002. Objectives To determine the effica... Read More

Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study (2016)
Journal Article
Kalladka, D., Sinden, J., Pollock, K., Haig, C., McLean, J., Smith, W., …Muir, K. W. (2016). Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet, 388(10046), 787-796. doi:10.1016/S0140-6736(16)30513-X

Background: CTX0E03 is an immortalised human neural stem-cell line from which a drug product (CTX-DP) was developed for allogeneic therapy. Dose-dependent improvement in sensorimotor function in rats implanted with CTX-DP 4 weeks after middle cerebra... Read More