Outputs (49)

Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting (2023)
Journal Article

Introduction: Rotavirus A is a major cause of acute dehydrating diarrhea in neonatal pigs resulting in significant mortality, morbidity, reduced performance and economic loss. Commercially available prebiotic galacto-oligosaccharides are similar to t... Read More about Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting.

Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance (2022)
Journal Article

The primary objective of this study was to investigate if common colonic community indicators could be identified from the microbiota of 22-day-old suckling pigs in repeated small-scale trials. A total of three separate trials were conducted at diffe... Read More about Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance.

Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator (2021)
Journal Article

A novel Gram-stain negative, aerobic, halotolerant, motile, rod-shaped, predatory bacterium ASxL5T, was isolated from a bovine slurry tank in Nottinghamshire, UK using Campylobacter hyointestinalis as prey. Other Campylobacter species and members of... Read More about Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator.

Bacteriophage therapy to reduce colonization of campylobacter jejuni in broiler chickens before slaughter (2021)
Journal Article

Campylobacteriosis is the most commonly reported gastrointestinal disease in humans. Campybacter jejuni is the main cause of the infection, and bacterial colonization in broiler chickens is widespread and difficult to prevent, leading to high risk of... Read More about Bacteriophage therapy to reduce colonization of campylobacter jejuni in broiler chickens before slaughter.

Acetate and auto-inducing peptide are independent triggers of quorum sensing in Lactobacillus plantarum (2021)
Journal Article

The synthesis of plantaricin in Lactobacillus plantarum is regulated by quorum sensing. However, the nature of the extra-cytoplasmic (EC) sensing domain of the histidine kinase (PlnB1) and the ability to recognize the auto-inducing peptide PlnA1 is n... Read More about Acetate and auto-inducing peptide are independent triggers of quorum sensing in Lactobacillus plantarum.

Bacteriophages to control multi-drug resistant enterococcus faecalis infection of dental root canals (2021)
Journal Article

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Phage therapy is an alternative treatment to antibiotics that can overcome multi-drug resistant bacteria. In this study, we aimed to isolate and characterize lytic bacteriophages targeted agai... Read More about Bacteriophages to control multi-drug resistant enterococcus faecalis infection of dental root canals.

Food biotechnology (2020)
Journal Article

We investigate recent advances in the Chemical Engineering aspects of food structuring agents and macronutrients: carbohydrates, proteins and lipids, and also the fate of food upon ingestion. Prebiotic effects on host-microbe interactions enable impr... Read More about Food biotechnology.

Campylobacter bacteriophage DA10: An excised temperate bacteriophage targeted by CRISPR-cas (2020)
Journal Article

Background: Lytic bacteriophages that infect Campylobacter spp. have been utilized to develop therapeutic/decontamination techniques. However, the association of Campylobacter spp. and bacteriophages has been the focus of several strands of research... Read More about Campylobacter bacteriophage DA10: An excised temperate bacteriophage targeted by CRISPR-cas.

Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia (2020)
Journal Article

© Copyright © 2020 The State of Queensland (through the Department Agriculture and Fisheries). This study describes the development and use of bacteriophage cocktails to control Campylobacter in broiler chickens, in a commercial setting, in Queenslan... Read More about Bacteriophages to Control Campylobacter in Commercially Farmed Broiler Chickens, in Australia.

Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy (2020)
Journal Article

© 2020 by the authors. Developing novel antimicrobials capable of controlling multidrug-resistant bacterial pathogens is essential to restrict the use of antibiotics. Bacteriophages (phages) constitute a major resource that can be harnessed as an alt... Read More about Bacteriophage ZCSE2 is a Potent Antimicrobial against Salmonella enterica Serovars: Ultrastructure, genomics and efficacy.

Application of a novel phage LPSEYT for biological control of Salmonella in foods (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella is a leading cause of foodborne diseases, and in recent years, many isolates have exhibited a high level of antibiotic resistance, which has led to huge pressures on public health.... Read More about Application of a novel phage LPSEYT for biological control of Salmonella in foods.

Development of a lyophilization process for Campylobacter bacteriophage storage and transport (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stabili... Read More about Development of a lyophilization process for Campylobacter bacteriophage storage and transport.

Application of a broad range lytic phage LPST94 for biological control of salmonella in foods (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella, one of the most common food-borne pathogens, is a significant public health and economic burden worldwide. Lytic phages are viable alternatives to conventional technologies for pat... Read More about Application of a broad range lytic phage LPST94 for biological control of salmonella in foods.

Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens (2020)
Journal Article

© Copyright © 2020 Flaujac Lafontaine, Richards, Connerton, O’Kane, Ghaffar, Cummings, Fish and Connerton. Worldwide Campylobacter jejuni is a leading cause of foodborne disease. Contamination of chicken meat with digesta from C. jejuni-positive bird... Read More about Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens.

Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance (2020)
Journal Article

Copyright © 2020 Richards et al Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens... Read More about Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance.

Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot (2020)
Journal Article

Copyright © 2020 Hobley et al. Bacteria are preyed upon by diverse microbial predators, including bacteriophage and predatory bacteria, such as Bdellovibrio bacteriovorus. While bacteriophage are used as antimicrobial therapies in Eastern Europe and... Read More about Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot.

Resistance mechanisms adopted by a Salmonella Typhimurium mutant against bacteriophage (2019)
Journal Article

© 2019 Elsevier B.V. Bacteriophages have key roles in regulating bacterial populations in most habitats. A Salmonella Typhimurium mutant (N18) with impaired sensitivity to phage fmb-p1 was obtained and examined, the adsorption efficiency of fmb-p1 to... Read More about Resistance mechanisms adopted by a Salmonella Typhimurium mutant against bacteriophage.

Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure (2019)
Journal Article

Campylobacter jejuni is a leading cause of foodborne illness globally. In this study, a spray drying and packaging process was developed to produce a thermally-stable dry powder containing bacteriophages that retains biological activity against C. je... Read More about Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure.

Encapsulation of E. coli phage ZCEC5 in chitosan-alginate beads as a delivery system in phage therapy (2019)
Journal Article

© 2019, The Author(s). Bacteriophages can be used successfully to treat pathogenic bacteria in the food chain including zoonotic pathogens that colonize the intestines of farm animals. However, harsh gastric conditions of low pH and digestive enzyme... Read More about Encapsulation of E. coli phage ZCEC5 in chitosan-alginate beads as a delivery system in phage therapy.

Understanding “corruption” in regulatory agencies: The case of food inspection in Saudi Arabia (2019)
Journal Article

Corruption is a relatively neglected topic in studies of regulatory agencies. The label is applied to a wide range of deviations from behavioral standards ultimately derived from Weber's account of the ideals of Prussian bureaucracy. This paper draws... Read More about Understanding “corruption” in regulatory agencies: The case of food inspection in Saudi Arabia.

Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota (2019)
Journal Article

Bacteriophage biocontrol to reduce Campylobacter jejuni levels in chickens can reduce human exposure and disease acquired through the consumption of contaminated poultry products.Investigating changes in the chicken microbiota during phage treatment... Read More about Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota.

FlhF(T368A) modulates motility in the bacteriophage carrier state of Campylobacter jejuni (2018)
Journal Article

© 2018 The Authors. Molecular Microbiology Published by John Wiley & Sons Ltd. The carrier state is an alternative bacteriophage life cycle by which virulent bacteriophage can persist in association with host bacteria. Campylobacter jejuni carrier... Read More about FlhF(T368A) modulates motility in the bacteriophage carrier state of Campylobacter jejuni.

Bacteriophage ZCKP1: a potential treatment for Klebsiella pneumoniae isolated from diabetic foot patients (2018)
Journal Article

The recorded growth in infection by multidrug resistant bacteria necessitates prompt efforts towards developing alternatives to antibiotics, such as bacteriophage therapy. Immuno-compromised patients with diabetes mellitus are particularly prone to f... Read More about Bacteriophage ZCKP1: a potential treatment for Klebsiella pneumoniae isolated from diabetic foot patients.

The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens (2018)
Journal Article

Background Campylobacters are an unwelcome member of the poultry gut microbiota in terms of food safety. The objective of this study was to compare the microbiota, inflammatory responses, and zootechnical parameters of broiler chickens not exposed t... Read More about The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens.

Editorial: About the Foodborne Pathogen Campylobacter (2017)
Journal Article

Characterisation of aerotolerant forms of a robust chicken colonizing Campylobacter coli (2017)
Journal Article

Campylobacter contaminated poultry meat is a major source of human foodborne illness. Campylobacter coli strain OR12 is a robust colonizer of chickens that was previously shown to outcompete and displace other Campylobacter strains from the chicken’s... Read More about Characterisation of aerotolerant forms of a robust chicken colonizing Campylobacter coli.

The minor flagellin of Campylobacter jejuni (FlaB) confers defensive properties against bacteriophage infection (2016)
Journal Article

A screen of bacteriophages infecting a panel of Campylobacter jejuni PT14 gene knock-out mutants identified a role for the minor flagellin encoded by the flaB gene, in the defense of the host against CP8unalikevirus bacteriophage CP_F1 infection. Ina... Read More about The minor flagellin of Campylobacter jejuni (FlaB) confers defensive properties against bacteriophage infection.

Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol (2016)
Journal Article

Consumption of foods containing chicken liver has been associated with Campylobacter enteritis. Campylobacters can contaminate the surface of livers post-mortem but can also arise through systemic infection of colonising bacteria in live birds. The u... Read More about Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol.

The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized (2016)
Journal Article

Starches from three organically produced cultivars of potato tuber (Lady Rosetta, Spunta and Voyager) have been studied in relation to (i) acrylamide production (ii) macromolecular integrity after frying with extra virgin olive oil, soybean oil and c... Read More about The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized.

The bacteriophage carrier state of Campylobacter jejuni features changes in host non-coding RNAs and the acquisition of new host-derived CRISPR spacer sequences (2016)
Journal Article

Incorporation of self-derived CRISPR DNA protospacers in Campylobacter jejuni PT14 occurs in the presence of bacteriophages encoding a CRISPR-like Cas4 protein. This phenomenon was evident in carrier state infections where both bacteriophages and ho... Read More about The bacteriophage carrier state of Campylobacter jejuni features changes in host non-coding RNAs and the acquisition of new host-derived CRISPR spacer sequences.

Pilot study of long-term anaesthesia in broiler chickens (2016)
Journal Article

Objective: To provide stable anaesthesia of long duration in broiler chickens in order to perform a terminal caecal ligated loop procedure. Study design: Prospective experimental study. Animals: Seven clinically healthy broiler chickens (Gallus... Read More about Pilot study of long-term anaesthesia in broiler chickens.

Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 (2016)
Journal Article

Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences. Phase-variable meth... Read More about Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168.

Filamentation of Campylobacter in broth cultures (2015)
Journal Article

The transition from rod to filamentous cell morphology has been identified as a response to stressful conditions in many bacterial species and has been ascribed to confer certain survival advantages. Filamentation of Campylobacter jejuni was demonstr... Read More about Filamentation of Campylobacter in broth cultures.

Host adaption to the bacteriophage carrier state of Campylobacter jejuni (2015)
Journal Article

The carrier state of the foodborne pathogen Campylobacter jejuni represents an alternative life cycle whereby virulent bacteriophage can persistent in association with host bacteria without commitment to lysogeny. Host bacteria exhibit significant ph... Read More about Host adaption to the bacteriophage carrier state of Campylobacter jejuni.

Xylan degrading enzymes from fungal sources (2015)
Journal Article

Fungi have the ability to degrade xylan as the major component of plant cell wall hemicellulose. Fungi have evolved batteries of xylanolytic enzymes that concertedly act to depolymerise xylan backbones decorated with variable carbohydrate branches. A... Read More about Xylan degrading enzymes from fungal sources.

Campylobacter jejuni acquire new host-derived CRISPR spacers when in association with bacteriophages harboring a CRISPR-like Cas4 protein (2015)
Journal Article

Campylobacter jejuni is a worldwide cause of human diarrhoeal disease. Clustered Repetitively Interspaced Palindromic Repeats (CRISPRs) and associated proteins allow Bacteria and Archaea to evade bacteriophage and plasmid infection. Type II CRISPR sy... Read More about Campylobacter jejuni acquire new host-derived CRISPR spacers when in association with bacteriophages harboring a CRISPR-like Cas4 protein.

Characterisation of a recombinant ?-xylosidase (xylA) from Aspergillus oryzae expressed in Pichia pastoris (2014)
Journal Article

β-xylosidases catalyse the hydrolysis of short chain xylooligosaccharides from their non-reducing ends into xylose. In this study we report the heterologous expression of Aspergillus oryzae β-xylosidase (XylA) in Pichia pastoris under the control of... Read More about Characterisation of a recombinant ?-xylosidase (xylA) from Aspergillus oryzae expressed in Pichia pastoris.

The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288 (2014)
Journal Article

Salmonella enterica Serovar Typhimurium U288 is an emerging pathogen of pigs. The strain contains three plasmids of diverse origin that encode traits that are of concern for food security and safety, these include antibiotic resistant determinants, a... Read More about The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288.

Food safety organisations in Saudi Arabia – organisational, historical and future analysis (2014)
Journal Article

Food safety organisations around the world are increasingly seeking to develop public policies to protect society, improve the economy, and ensure food safety and quality, by reducing the risks of food-borne illnesses, commercial adulteration, and fo... Read More about Food safety organisations in Saudi Arabia – organisational, historical and future analysis.

Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni (2014)
Journal Article

Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding... Read More about Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni.

Heterologous expression and kinetic characterisation of Neurospora crassa ?-xylosidase in Pichia pastoris (2014)
Journal Article

To degrade plant hemicelluloses fungi employ β-xylosidases to hydrolyse xylooligosaccharides, released by endo-xylanases, into xylose. We have expressed the β-xylosidase from Neurospora crassa in Pichia pastoris under the control of alcohol oxidase 1... Read More about Heterologous expression and kinetic characterisation of Neurospora crassa ?-xylosidase in Pichia pastoris.

Complete genome sequence of universal bacteriophage host strain Campylobacter jejuni subsp. jejuni PT14 (2013)
Journal Article

Campylobacter jejuni strain PT14 is a clinical isolate previously used to propagate bacteriophages in the United Kingdom phage typing scheme. The strain has proven useful in the isolation of Campylobacter bacteriophages from several sources, and it f... Read More about Complete genome sequence of universal bacteriophage host strain Campylobacter jejuni subsp. jejuni PT14.

Complete genome sequence of Salmonella enterica serovar Typhimurium U288 (2013)
Journal Article

Salmonella enterica serovar Typhimurium U288 has firmly established itself within the United Kingdom pig production industry. The prevalence of this highly pathogenic multidrug-resistant serovar at such a critical point in the food chain is therefore... Read More about Complete genome sequence of Salmonella enterica serovar Typhimurium U288.

A suggested classification for two groups of Campylobacter myoviruses (2013)
Journal Article

Most Campylobacter bacteriophages isolated to date have long contractile tails and belong to the family Myoviridae. Based on their morphology, genome size and endonuclease restriction profile, Campylobacter phages were originally divided into three g... Read More about A suggested classification for two groups of Campylobacter myoviruses.

Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation (2012)
Journal Article

Campylobacter jejuni is an important human food-borne intestinal pathogen, however relatively little is known about its mechanisms of pathogenesis or pathogen-host interactions. To monitor changes in gene expression and glycan binding of C. jejuni wi... Read More about Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation.

Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens (2005)
Journal Article

Colonization of broiler chickens by the enteric pathogen Campylobacter jejuni is widespread and difficult to prevent. Bacteriophage therapy is one possible means by which this colonization could be controlled, thus limiting the entry of campylobacter... Read More about Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens.

Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca (2005)
Journal Article

Campylobacter jejuni and Campylobacter-specific bacteriophage were enumerated from broiler chicken ceca selected from 90 United Kingdom flocks (n = 205). C. jejuni counts in the presence of bacteriophage (mean log10 5.1 CFU/g) were associated with a... Read More about Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca.

Application of host-specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni (2003)
Journal Article

Retail poultry products are widely purported as the major infection vehicle for human campylobacteriosis. Numerous intervention strategies have sought to reduce Campylobacter contamination on broiler carcasses in the abattoir. This study reports the... Read More about Application of host-specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni.

Isolation and characterization of Campylobacter bacteriophages from retail poultry (2003)
Journal Article

The ability of phages to survive processing is an important aspect of their potential use in the biocontrol of Campylobacter in poultry production. To this end, we have developed a procedure to recover Campylobacter bacteriophages from chilled and fr... Read More about Isolation and characterization of Campylobacter bacteriophages from retail poultry.