Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity (2023)
Journal Article
Portelli, M. A., Bhaker, S., Pang, V., Bates, D. O., Johnson, S. R., Mazar, A. P., …Sayers, I. (2023). Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity. Clinical and Translational Allergy, 13(10), Article e12293. https://doi.org/10.1002/clt2.12293

AbstractBackgroundExpression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown.Objective... Read More about Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity.

Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network (2021)
Journal Article
Ifesemen, O. S., McWilliams, D. F., Norton, S., Kiely, P. D. W., Young, A., & Walsh, D. A. (2022). Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network. Rheumatology, 61(9), 3737-3745. https://doi.org/10.1093/rheumatology/keab947

OBJECTIVES: Fatigue is a disabling symptom in people with RA. This study aims to describe the prevalence, risk factors and longitudinal course of fatigue in early RA. METHODS: Demographic, clinical, quality of life (QoL), comorbidities and laboratory... Read More about Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.

Impacts of the COVID-19 pandemic and self-isolation on students and staff in higher education: A qualitative study (2021)
Journal Article
Knight, H., Carlisle, S., O’connor, M., Briggs, L., Fothergill, L., Al-Oraibi, A., …Blake, H. (2021). Impacts of the COVID-19 pandemic and self-isolation on students and staff in higher education: A qualitative study. International Journal of Environmental Research and Public Health, 18(20), Article 10675. https://doi.org/10.3390/ijerph182010675

This qualitative study explored the impact of COVID-19 self-isolation and social restriction measures on university students, through the perspectives of both students and the staff supporting them. The study comprised 11 focus groups (students) and... Read More about Impacts of the COVID-19 pandemic and self-isolation on students and staff in higher education: A qualitative study.

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis (2021)
Journal Article
McWilliams, D. F., Thankaraj, D., Jones-Diette, J., Morgan, R., Ifesemen, O. S., Shenker, N. G., & Walsh, D. A. (2022). The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis. Rheumatology, 61(1), 76-89. https://doi.org/10.1093/rheumatology/keab503

Objectives: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods: A systematic literature review of ra... Read More about The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study (2021)
Journal Article
Ifesemen, O., McWilliams, D. F., Ferguson, E., Wakefield, R., Akin-Akinyosoye, K., Wilson, D., …Walsh, D. A. (2021). Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study. BMC Rheumatology, 5(1), Article 23. https://doi.org/10.1186/s41927-021-00187-2

Background: Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-repor... Read More about Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.

Understanding the cost of mental health at work: an integrative framework (2021)
Book Chapter
Hassard, J., Teoh, K., Thomson, L., & Blake, H. (2021). Understanding the cost of mental health at work: an integrative framework. In T. Wall, C. Cooper, & P. Brough (Eds.), The SAGE Handbook of Organisational Wellbeing. SAGE Publications

Internationally, there is growing recognition of the social and economic impact of work-related stress and mental ill-health; and, in turn, of the relative importance of promoting mental wellbeing and preventing the onset of mental disorders at work... Read More about Understanding the cost of mental health at work: an integrative framework.

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. (2021). Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study. International Journal of Environmental Research and Public Health, 18(8), Article 4182. https://doi.org/10.3390/ijerph18084182

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article
Heissam, K., Abrehart, N., Hoad, C. L., Wright, J., Menys, A., Murray, K., …Marciani, L. (2020). Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS ONE, 15(11), e0241441. https://doi.org/10.1371/journal.pone.0241441

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment (2020)
Journal Article
John, G., Welsh, C., Majid, Z., Masud, T., Jackson, T., & Grieg, C. (2021). Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment. Age and Ageing, 50(2), 394-404. https://doi.org/10.1093/ageing/afaa209

Objective: Assimilate evidence for interventions to ameliorate negative changes in physical performance, muscle strength, and muscle quantity in hospitalised older adults. Methods: We searched for articles using MEDLINE, Embase, CINAHL, and Cochr... Read More about Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment.

Preventive digital mental health interventions for children and young people: a review of the design and reporting of research (2020)
Journal Article
Bergin, A. D., Vallejos, E. P., Davies, E. B., Daley, D., Ford, T., Harold, G., …Hollis, C. (2020). Preventive digital mental health interventions for children and young people: a review of the design and reporting of research. npj Digital Medicine, 3(1), Article 133. https://doi.org/10.1038/s41746-020-00339-7

Digital health interventions (DHIs) have frequently been highlighted as one way to respond to increasing levels of mental health problems in children and young people. Whilst many are developed to address existing mental health problems, there is als... Read More about Preventive digital mental health interventions for children and young people: a review of the design and reporting of research.

Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review (2020)
Journal Article
Wang, H., Swain, S., Luo, J., Blake, H., & Chattopadhyay, K. (2020). Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review. JBI Evidence Synthesis, 18(12), 2445-2511. https://doi.org/10.11124/JBISRIR-D-19-00154

Objective: The review aimed to synthesize the barriers and facilitators from the available studies that dealt with physical activity among ethnic Chinese children and uncover any differences or similarities in these barriers and facilitators. In... Read More about Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review.

Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation (2020)
Journal Article
Sharif, H., Abrehart, N., Hoad, C., Murray, K., Perkins, A., Smith, M., …Marciani, L. (2020). Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation. Journal of Pediatric Gastroenterology and Nutrition, 71(5), 604-611. https://doi.org/10.1097/MPG.0000000000002910

Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the X-ray radiopaque marker (ROM) test, give... Read More about Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation.

Processing Apples to Puree or Juice Speeds Gastric Emptying and Reduces Postprandial Intestinal Volumes and Satiety in Healthy Adults (2020)
Journal Article
Krishnasamy, S., Lomer, M. C. E., Marciani, L., Hoad, C. L., Pritchard, S. E., Paul, J., …Spiller, R. C. (2020). Processing Apples to Puree or Juice Speeds Gastric Emptying and Reduces Postprandial Intestinal Volumes and Satiety in Healthy Adults. Journal of Nutrition, 150(11), 2890-2899. https://doi.org/10.1093/jn/nxaa191

Background: Whole apples produce greater satiety than processed apples, but the underlying mechanisms remain unclear. Objective: Our aim was to assess the intragastric processing of apple preparations and the associated small and large bowel conten... Read More about Processing Apples to Puree or Juice Speeds Gastric Emptying and Reduces Postprandial Intestinal Volumes and Satiety in Healthy Adults.

Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era (2020)
Journal Article
Lawrence, R. J., O'Donoghue, G., Kitterick, P., O'Donoghue, K., Hague, R., Mitchell, L., …Hartley, D. E. (2020). Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era. Laryngoscope, 130(11), 2693-2699. https://doi.org/10.1002/lary.29014

© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA) Objectives/Hypothesis: The overall aim of this study was to evaluate personal protective equipment (PPE)... Read More about Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era.

A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging (2020)
Journal Article
Tournier, J.-D., Christiaens, D., Hutter, J., Price, A. N., Cordero-Grande, L., Hughes, E., …Hajnal, J. V. (2020). A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging. NMR in Biomedicine, 33(9), Article e4348. https://doi.org/10.1101/661348

Diffusion MRI has the potential to provide important information about the connectivity and microstructure of the human brain during normal and abnormal development, non-invasively and in vivo. Recent developments in MRI hardware and reconstruction m... Read More about A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging.

Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus (2020)
Journal Article
Pierzycki, R., & Kitterick, P. (2021). Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus. Ear and Hearing, 42(1), 235-243. https://doi.org/10.1097/aud.0000000000000900

Objective: Determine the prevalence of clinical insomnia and its associations with anxiety, depression, and tinnitus in adult cochlear implant (CI) users. Design: Self-reported information on tinnitus, sleep, and demographic variables was... Read More about Insomnia, Anxiety and Depression in Adult Cochlear Implant Users With Tinnitus.

Improved fibre dispersion estimation using b-tensor encoding (2020)
Journal Article
Cottaar, M., Szczepankiewicz, F., Bastiani, M., Hernandez-Fernandez, M., Sotiropoulos, S. N., Nilsson, M., & Jbabdi, S. (2020). Improved fibre dispersion estimation using b-tensor encoding. NeuroImage, 215, Article 116832. https://doi.org/10.1016/j.neuroimage.2020.116832

© 2020 The Authors Measuring fibre dispersion in white matter with diffusion magnetic resonance imaging (MRI) is limited by an inherent degeneracy between fibre dispersion and microscopic diffusion anisotropy (i.e., the diffusion anisotropy expected... Read More about Improved fibre dispersion estimation using b-tensor encoding.

Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing (2020)
Journal Article
Autio, J. A., Glasser, M. F., Ose, T., Donahue, C. J., Bastiani, M., Ohno, M., …Hayashi, T. (2020). Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing. NeuroImage, 215, Article 116800. https://doi.org/10.1016/j.neuroimage.2020.116800

© 2020 The Author(s) Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization of primates including humans. However, the tools and methods for noninvasive image acquis... Read More about Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing.

Investigating musculoskeletal health and wellbeing; A cohort study protocol (2020)
Journal Article
Millar, B., McWilliams, D. F., Abhishek, A., Akin-Akinyosoye, K., Auer, D. P., Chapman, V., …Walsh, D. A. (2020). Investigating musculoskeletal health and wellbeing; A cohort study protocol. BMC Musculoskeletal Disorders, 21(1), Article 182. https://doi.org/10.1186/s12891-020-03195-4

© 2020 The Author(s). Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Heal... Read More about Investigating musculoskeletal health and wellbeing; A cohort study protocol.