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Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota

Richards, Philip J.; Connerton, Phillippa L.; Connerton, Ian F.

Authors

Philip J. Richards

Phillippa L. Connerton

IAN CONNERTON IAN.CONNERTON@NOTTINGHAM.AC.UK
Northern Foods Professor of Food Safety



Abstract

Bacteriophage biocontrol to reduce Campylobacter jejuni levels in chickens can reduce human exposure and disease acquired through the consumption of contaminated poultry products.Investigating changes in the chicken microbiota during phage treatment has not previously been undertaken but is crucial to understanding the system-wide effects of such treatments to establish a sustainable application. A phage cocktail containing two virulent Campylobacter phages was used to treat broiler chickens colonized with C. jejuni HPC5. Campylobacter counts from cecal contents were significantly reduced throughout the experimental period but were most effectivedays post-treatment showing a reduction of 2.4 log10 CFU g-1 19 relative to mock-treated Campylobacter colonized controls. The administered phages replicated in vivo to establish stable populations. Bacteriophage predation of C. jejuni was not found to affect the microbiota structure but selectively reduced the relative abundance of C. jejuni without affecting other bacteria.

Journal Article Type Article
Publication Date Mar 12, 2019
Journal Frontiers in Microbiology
Electronic ISSN 1664-302X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 10
Article Number 476
APA6 Citation Richards, P. J., Connerton, P. L., & Connerton, I. F. (2019). Phage control of Campylobacter jejuni in chickens does not produce collateral effects on the gut microbiota. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.00476
DOI https://doi.org/10.3389/fmicb.2019.00476
Keywords Bacteriophage; Campylobacter; Microbiota; Chicken; Biocontrol
Publisher URL https://www.frontiersin.org/articles/10.3389/fmicb.2019.00476/full

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