All Outputs (21)

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system (2020)
Journal Article

Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that... Read More about Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system.

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia (2020)
Journal Article

Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angioge... Read More about The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.

A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy (2020)
Journal Article

© 2020, The Author(s). The oxidation status of angiotensinogen (AGT) may have a critical role in pre-eclampsia. We used a validated, quantitative, mass spectrometry-based method to measure the oxidized and total AGT levels in plasma of pre-eclamptic... Read More about A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy.

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More about Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications.

Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia (2019)
Journal Article

Background: Women with chronic kidney disease (CKD) are at increased risk of superimposed preeclampsia (SPE). Accurate identification of SPE is challenging. We hypothesised that specific components of the renin-angiotensin-aldosterone-system (RAAS) w... Read More about Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia.

Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension (2018)
Journal Article

Objectives: Postpartum stratification of cardiovascular risk for women with pregnancies complicated by pre-eclampsia is challenging. Our aim was to identify potential clinical and biomarker predictors of future cardiovascular risk at six weeks postpa... Read More about Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension.

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia (2017)
Journal Article

Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD. We hypothesized that in preeclampsia there would be a disruption of maternal/fetal p... Read More about Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia.

Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult (2016)
Journal Article

A functioning placental renin–angiotensin system (RAS) appears necessary for uncomplicated pregnancy and is present during placentation, which occurs under low oxygen tensions. Placental RAS is increased in pre-eclampsia (PE), characterised by placen... Read More about Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Expression of voltage-dependent potassium channels in first trimester human placentae (2014)
Journal Article

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCN... Read More about Expression of voltage-dependent potassium channels in first trimester human placentae.

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype (2013)
Journal Article

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-... Read More about Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype.

Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy (2013)
Journal Article

Pre-eclampsia is associated with lower serum selenium concentrations and glutathione peroxidase expression/activity; total thyroid hormones are also lower. Objectives, study design and main outcome measures: We hypothesised that the placental seleno... Read More about Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.

The placental renin-angiotensin system and oxidative stress in pre-eclampsia (2012)
Journal Article

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-e... Read More about The placental renin-angiotensin system and oxidative stress in pre-eclampsia.

Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants (2012)
Journal Article

Pregnancy during adolescence increases the risk of adverse pregnancy outcome, especially risk of small-for gestational-age (SGA) birth, which has been linked to micronutrient deficiencies. Likewise, smoking has been shown to be related with lower mic... Read More about Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants.

Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia (2011)
Journal Article

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascu... Read More about Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia.

Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity (2011)
Journal Article

Pre-eclampsia affects between 2-7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations. Objectives: Firstly, t... Read More about Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity.

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy (2010)
Journal Article

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenopr... Read More about Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.