Lesia O. Kurlak
Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia
Kurlak, Lesia O.; Broughton Pipkin, Fiona; Mohaupt, Markus G.; Mistry, Hiten D.
Fiona Broughton Pipkin
Markus G. Mohaupt
Hiten D. Mistry
Background: Women with chronic kidney disease (CKD) are at increased risk of superimposed preeclampsia (SPE). Accurate identification of SPE is challenging. We hypothesised that specific components of the renin-angiotensin-aldosterone-system (RAAS) would discriminate between CKD and SPE. The aim of the study was to establish differences in circulating and intrarenal RAAS in women with CKD with and without SPE and compare these to normotensive controls (NC) and women with pre-eclampsia (PE).
Methods: White European NC women (n=20), women with PE (n=9), normotensive CKD without SPE (n=8) and with SPE (n=11) were recruited in the third trimester. Plasma renin, plasma and urine total angiotensinogen (AGT) concentrations were quantified by ELISA; urinary tetrahydroaldosterone (THaldo) concentration by gas chromatography-mass spectrometry and placental growth factor (PlGF) by immunoassay.
Results: Urinary TH-aldo:creatinine ratios were lower in women with PE or SPE compared to NC or women with CKD (P less than 0.05 for all). The same group differences were observed for plasma active renin and PlGF concentrations (P less than 0.05 for all). Urine total AGT was higher in women with PE compared with NC (P less than 0.05) and urine TH-aldo:urine AGT was lower (P less than 0.05). However, women with SPE had lower urinary AGT concentrations compared with women with PE (P less than 0.05). No differences in plasma total AGT were observed between groups.
Women with SPE have a lower urinary TH-aldo:creatinine ratio, lower plasma active renin and lower PlGF concentrations than women with CKD, comparable to women with PE without pre-existing disease, suggestive of similar pathophysiology. These data suggest disruption of the RAAS pathway in SPE similar to PE. Exploration of the predictive value of RAAS components for adverse pregnancy events in women with CKD is required.
|Journal Article Type||Article|
|Publication Date||Mar 25, 2019|
|Publisher||Oxford University Press|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Kurlak, L. O., Broughton Pipkin, F., Mohaupt, M. G., & Mistry, H. D. (2019). Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia. Clinical Kidney Journal, doi:10.1093/ckj/sfz025|
|Keywords||pregnancy, pre-eclampsia, chronic kidney disease, renin-angiotensin; system, Aldosterone, Angiotensinogen|
Resubmitted Proof CKJ Feb2019