Hiten D. Mistry
Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia
Mistry, Hiten D.; McCallum, Laura A.; Kurlak, Lesia O.; Greenwood, Iain A.; Broughton Pipkin, Fiona; Tribe, Rachel M.
Authors
Laura A. McCallum
Lesia O. Kurlak
Iain A. Greenwood
Fiona Broughton Pipkin
Rachel M. Tribe
Abstract
Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascular relaxation. KV7 channel function can be modulated by KCNE1-5 encoded accessory proteins. The aim of this study was to determine whether KCNQ and KCNE genes are differentially expressed in placentae from women with preeclampsia compared to normotensive controls and to examine any differences in those who delivered preterm (
Citation
Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011). Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia. Hypertension, 58, https://doi.org/10.1161/HYPERTENSIONAHA.111.173740
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 14, 2011 |
Online Publication Date | Aug 17, 2011 |
Publication Date | Sep 1, 2011 |
Deposit Date | Jul 19, 2017 |
Publicly Available Date | Mar 29, 2024 |
Journal | Hypertension |
Print ISSN | 2224-1485 |
Electronic ISSN | 0194-911X |
Publisher | Publishing House Zaslavsky |
Peer Reviewed | Peer Reviewed |
Volume | 58 |
DOI | https://doi.org/10.1161/HYPERTENSIONAHA.111.173740 |
Public URL | https://nottingham-repository.worktribe.com/output/707927 |
Publisher URL | http://hyper.ahajournals.org/content/58/3/497 |
Files
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