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Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia

Mistry, Hiten D.; McCallum, Laura A.; Kurlak, Lesia O.; Greenwood, Iain A.; Broughton Pipkin, Fiona; Tribe, Rachel M.

Authors

Hiten D. Mistry hiten.mistry@nottingham.ac.uk

Laura A. McCallum

Lesia O. Kurlak lesia.kurlak@nottingham.ac.uk

Iain A. Greenwood

Fiona Broughton Pipkin

Rachel M. Tribe



Abstract

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascular relaxation. KV7 channel function can be modulated by KCNE1-5 encoded accessory proteins. The aim of this study was to determine whether KCNQ and KCNE genes are differentially expressed in placentae from women with preeclampsia compared to normotensive controls and to examine any differences in those who delivered preterm (

Journal Article Type Article
Publication Date Sep 1, 2011
Journal Hypertension
Print ISSN 2224-1485
Electronic ISSN 0194-911X
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 58
Institution Citation Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011). Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia. Hypertension, 58, doi:10.1161/HYPERTENSIONAHA.111.173740
DOI https://doi.org/10.1161/HYPERTENSIONAHA.111.173740
Publisher URL http://hyper.ahajournals.org/content/58/3/497
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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KCN PE paper - 44267.pdf (235 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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