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Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia

Mistry, Hiten D.; McCallum, Laura A.; Kurlak, Lesia O.; Greenwood, Iain A.; Broughton Pipkin, Fiona; Tribe, Rachel M.

Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia Thumbnail


Authors

Hiten D. Mistry

Laura A. McCallum

Lesia O. Kurlak

Iain A. Greenwood

Fiona Broughton Pipkin

Rachel M. Tribe



Abstract

Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. KV7 (voltage-dependant potassium channels encoded by KCNQ1-5 genes) have been detected in several types of blood vessels where they promote vascular relaxation. KV7 channel function can be modulated by KCNE1-5 encoded accessory proteins. The aim of this study was to determine whether KCNQ and KCNE genes are differentially expressed in placentae from women with preeclampsia compared to normotensive controls and to examine any differences in those who delivered preterm (

Citation

Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011). Novel expression and regulation of voltage-dependent potassium (KV7) channels in placentae from women with preeclampsia. Hypertension, 58, https://doi.org/10.1161/HYPERTENSIONAHA.111.173740

Journal Article Type Article
Acceptance Date Jun 14, 2011
Online Publication Date Aug 17, 2011
Publication Date Sep 1, 2011
Deposit Date Jul 19, 2017
Publicly Available Date Mar 29, 2024
Journal Hypertension
Print ISSN 2224-1485
Electronic ISSN 0194-911X
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 58
DOI https://doi.org/10.1161/HYPERTENSIONAHA.111.173740
Public URL https://nottingham-repository.worktribe.com/output/707927
Publisher URL http://hyper.ahajournals.org/content/58/3/497

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