Skip to main content

Research Repository

Advanced Search

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype

Hentchke, Marta; Poli-de-Figueiredo, Carlos; Pinheiro da Costa, Bartira; Kurlak, L.O.; Williams, Paula Juliet; Mistry, Hiten D.

Authors

Marta Hentchke

Carlos Poli-de-Figueiredo

Bartira Pinheiro da Costa

L.O. Kurlak lesia.kurlak@nottingham.ac.uk

Paula Juliet Williams

Hiten D. Mistry hiten.mistry@nottingham.ac.uk



Abstract

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-regulated in pre-eclampsia, associated with increased maternal and fetal lipoprotein concentrations; 2) expression of these would be reduced in pre-eclamptic placentae from women delivering small-for-gestational-age (SGA) infants. Placental biopsies, maternal and umbilical serum samples were taken from 27 normotensive and 24 pre-eclamptic women. Maternal/umbilical cord serum LDL; HDL; total cholesterol and triglycerides were measured. Placental mRNA expression of lipoprotein receptors/transporters were quantified using qRT-PCR. Protein localisation/expression of LRP-1 in the pre-eclamptic with/without SGA was measured by immunohistochemistry. Placental mRNA expression of all genes except PON-1, MTTP and PDIA2 were observed. No differences for any lipoprotein receptors/transporters were found between groups; however, in the pre-eclamptic group placental LRP-1 expression was lower in SGA delivering mothers (n = 7; P=0.036). LRP-1 protein was localised around fetal vessels and Hofbauer cells. This is the first detailed study of maternal/fetal lipoprotein concentrations and placental lipoprotein receptor mRNA expression in normotensive and pre-eclamptic pregnancies. These findings do not support a role of altered lipid metabolism in pre-eclampsia, but may be involved in fetal growth.

Citation

Hentchke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Kurlak, L., Williams, P. J., & Mistry, H. D. (2013). Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54, https://doi.org/10.1194/jlr.M036699

Journal Article Type Article
Acceptance Date Jul 16, 2013
Online Publication Date Jul 29, 2013
Publication Date Oct 31, 2013
Deposit Date Jul 21, 2017
Publicly Available Date Jul 21, 2017
Journal Journal of Lipid Research
Print ISSN 0022-2275
Electronic ISSN 1539-7262
Publisher American Society for Biochemistry and Molecular Biology
Peer Reviewed Peer Reviewed
Volume 54
DOI https://doi.org/10.1194/jlr.M036699
Keywords Hypertension; Lipids; LDL cholesterol; HDL cholesterol; Triglycerides; ABCA1; LRP-1; LDL-R; SRB-1;Fetal growth
Public URL http://eprints.nottingham.ac.uk/id/eprint/44322
Publisher URL http://www.jlr.org/content/54/10/2658
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This research was originally published in Journal of Lipid Research. Marta R. Hentschke, Carlos E. Poli-de-Figueiredo, Bartira E. Pinheiro da Costa, Lesia O. Kurlak, Paula J. Williams, Hiten D. Mistry . Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research. 2013; Vol: 54 p. 2658-2664. © the American Society for Biochemistry and Molecular Biology.

Files

JLR reusb lipids paper_accepted.pdf (565 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations