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Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype

Hentchke, Marta; Poli-de-Figueiredo, Carlos; Pinheiro da Costa, Bartira; Kurlak, L.O.; Williams, Paula Juliet; Mistry, Hiten D.

Authors

Marta Hentchke

Carlos Poli-de-Figueiredo

Bartira Pinheiro da Costa

L.O. Kurlak lesia.kurlak@nottingham.ac.uk

Paula Juliet Williams

Hiten D. Mistry hiten.mistry@nottingham.ac.uk



Abstract

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-regulated in pre-eclampsia, associated with increased maternal and fetal lipoprotein concentrations; 2) expression of these would be reduced in pre-eclamptic placentae from women delivering small-for-gestational-age (SGA) infants. Placental biopsies, maternal and umbilical serum samples were taken from 27 normotensive and 24 pre-eclamptic women. Maternal/umbilical cord serum LDL; HDL; total cholesterol and triglycerides were measured. Placental mRNA expression of lipoprotein receptors/transporters were quantified using qRT-PCR. Protein localisation/expression of LRP-1 in the pre-eclamptic with/without SGA was measured by immunohistochemistry. Placental mRNA expression of all genes except PON-1, MTTP and PDIA2 were observed. No differences for any lipoprotein receptors/transporters were found between groups; however, in the pre-eclamptic group placental LRP-1 expression was lower in SGA delivering mothers (n = 7; P=0.036). LRP-1 protein was localised around fetal vessels and Hofbauer cells. This is the first detailed study of maternal/fetal lipoprotein concentrations and placental lipoprotein receptor mRNA expression in normotensive and pre-eclamptic pregnancies. These findings do not support a role of altered lipid metabolism in pre-eclampsia, but may be involved in fetal growth.

Journal Article Type Article
Publication Date Oct 31, 2013
Journal Journal of Lipid Research
Print ISSN 0022-2275
Electronic ISSN 1539-7262
Publisher American Society for Biochemistry and Molecular Biology
Peer Reviewed Peer Reviewed
Volume 54
APA6 Citation Hentchke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Kurlak, L., Williams, P. J., & Mistry, H. D. (2013). Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54, doi:10.1194/jlr.M036699
DOI https://doi.org/10.1194/jlr.M036699
Keywords Hypertension; Lipids; LDL cholesterol; HDL cholesterol; Triglycerides; ABCA1; LRP-1; LDL-R; SRB-1;Fetal growth
Publisher URL http://www.jlr.org/content/54/10/2658
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This research was originally published in Journal of Lipid Research. Marta R. Hentschke, Carlos E. Poli-de-Figueiredo, Bartira E. Pinheiro da Costa, Lesia O. Kurlak, Paula J. Williams, Hiten D. Mistry . Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research. 2013; Vol: 54 p. 2658-2664. © the American Society for Biochemistry and Molecular Biology.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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