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Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

Stöger, Reinhard; Scaife, Paula; Shephard, Freya; Chakrabarti, Lisa

Authors

Reinhard Stöger

Paula Scaife

Freya Shephard

Lisa Chakrabarti



Abstract

5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson’s disease and control DNA sample sets. In contrast, median 5-hydroxymethylcytosine levels were almost twice as high (p 

Journal Article Type Article
Journal npj Parkinson's Disease
Electronic ISSN 2373-8057
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 3
Issue 6
APA6 Citation Stöger, R., Scaife, P., Shephard, F., & Chakrabarti, L. (in press). Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease. npj Parkinson's Disease, 3(6), https://doi.org/10.1038/s41531-017-0007-3
DOI https://doi.org/10.1038/s41531-017-0007-3
Keywords DNA, epigenetics, Parkinson's disease
Publisher URL http://www.nature.com/articles/s41531-017-0007-3
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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