The placental renin-angiotensin system and oxidative stress in pre-eclampsia

Mistry, H.D.; Kurlak, L.O.; Broughton Pipkin, Fiona

Abstract

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, manifests as high blood pressure and proteinuria, and is a state of increased oxidative stress.
Objectives, study design and main outcome measures
Hypothesis: Pre-eclampsia will be associated with increased placental expression of components of the renin–angiotensin system, which could result in reduced infant birthweight. Biopsies were taken 1 cm from the placental edge from 27 normotensive controls and 23 pre-eclamptic White European women. Immunohistochemistry was performed for AGT, PRR, glutathione peroxidase 3 (GPx3) and the AT1R and AT2R AngII receptors. Protein expression was semi-quantitatively assessed (H-score).
Results: AT1R expression was significantly increased in pre-eclamptic placentae, and negatively correlated with birthweight (r = −0.529, P = 0.009). AT1R expression was also negatively correlated with GPx3 expression overall (r = −0.647; P = 0.005). AT2R expression positively correlated with AGT (r = 0.615, P = 0.002) in the pre-eclamptic placentae only.
Conclusions: The raised AT1R expression in pre-eclampsia, together with inadequate antioxidant protection, possibly through lower GPx activity, might enhance the vasoconstrictor effect of locally-generated AngII, contributing to the restricted fetal growth characteristic of pre-eclampsia. Conversely, the AT2R:AGT association within the pre-eclamptic placenta may provide a compensatory mechanism.

Citation

Mistry, H., Kurlak, L., & Broughton Pipkin, F. (2013). The placental renin-angiotensin system and oxidative stress in pre-eclampsia. Placenta, 34(2), https://doi.org/10.1016/j.placenta.2012.11.027

• Journal Article Type: Article
• Acceptance Date: Nov 26, 2012
• Online Publication Date: Dec 14, 2012
• Publication Date: Feb 1, 2013
• Deposit Date: Jul 19, 2017
• Publicly Available Date: Jul 19, 2017
• Journal: Placenta
• Print ISSN: 0143-4004
• Electronic ISSN: 1532-3102
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 2
• DOI: https://doi.org/10.1016/j.placenta.2012.11.027
• Public URL: http://eprints.nottingham.ac.uk/id/eprint/44270
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0143400412004626?via%3Dihub
• Copyright Statement: Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf