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Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D.; Kurlak, L.O.; Whitley, Guy S.; Cartwright, Judith E.; Broughton Pipkin, Fiona; Tribe, Rachel M.

Authors

Hiten D. Mistry hiten.mistry@nottingham.ac.uk

L.O. Kurlak lesia.kurlak@nottingham.ac.uk

Guy S. Whitley

Judith E. Cartwright

Fiona Broughton Pipkin

Rachel M. Tribe



Abstract

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at 10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

Citation

Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

Journal Article Type Article
Acceptance Date Feb 20, 2014
Online Publication Date Mar 3, 2014
Publication Date May 31, 2014
Deposit Date Jul 21, 2017
Publicly Available Date Jul 21, 2017
Journal Placenta
Print ISSN 0143-4004
Electronic ISSN 1532-3102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 35
Issue 5
DOI https://doi.org/10.1016/j.placenta.2014.02.008
Keywords Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE
Public URL http://eprints.nottingham.ac.uk/id/eprint/44325
Publisher URL http://www.sciencedirect.com/science/article/pii/S0143400414000824
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

Files

KCN TOP resubmission Placenta accepted.pdf (210 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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