Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D.; Kurlak, L.O.; Whitley, Guy S.; Cartwright, Judith E.; Broughton Pipkin, Fiona; Tribe, Rachel M.

Abstract

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at 10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

Citation

Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

• Journal Article Type: Article
• Acceptance Date: Feb 20, 2014
• Online Publication Date: Mar 3, 2014
• Publication Date: May 31, 2014
• Deposit Date: Jul 21, 2017
• Publicly Available Date: Jul 21, 2017
• Journal: Placenta
• Print ISSN: 0143-4004
• Electronic ISSN: 1532-3102
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 5
• DOI: https://doi.org/10.1016/j.placenta.2014.02.008
• Keywords: Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE
• Public URL: https://nottingham-repository.worktribe.com/output/728006
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0143400414000824