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Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system

Kurlak, L.O.; Williams, Paula Juliet; Bulmer, Judith N.; Broughton Pipkin, Fiona; Mistry, Hiten D.

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system Thumbnail


Authors

L.O. Kurlak

Paula Juliet Williams

Judith N. Bulmer

Fiona Broughton Pipkin

Hiten D. Mistry



Abstract

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiogenesis and vascularisation. We hypothesised that placental adenosine A2AR receptor and HIF-1α would change through pregnancy in association with the RAS. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations; at delivery from normotensive (NT) and PE pregnancy. Results were compared to our previously reported data on the angiotensin receptors: AT1R, AT2R and AT4R.
Protein expression of both A2AR and HIF-1α was highest in early TOP and positively correlated through pregnancy (P

Citation

Kurlak, L., Williams, P. J., Bulmer, J. N., Broughton Pipkin, F., & Mistry, H. D. (2015). Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.011

Journal Article Type Article
Acceptance Date Feb 16, 2015
Online Publication Date Feb 24, 2015
Publication Date May 1, 2015
Deposit Date Jul 21, 2017
Publicly Available Date Mar 29, 2024
Journal Placenta
Print ISSN 0143-4004
Electronic ISSN 1532-3102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 36
Issue 5
DOI https://doi.org/10.1016/j.placenta.2015.02.011
Keywords Placental A2AR; HIF-1?: angiotensin receptors; Early pregnancy; Pre-eclampsia
Public URL https://nottingham-repository.worktribe.com/output/983878
Publisher URL http://www.sciencedirect.com/science/article/pii/S0143400415008103

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