Skip to main content

Research Repository

Advanced Search

Browse


Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats (2020)
Journal Article
Aso, K., Shahtaheri, S. M., Hill, R., Wilson, D., McWilliams, D. F., Nwosu, L. N., …Walsh, D. A. (2020). Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.05.010

© 2020 Osteoarthritis Research Society International Objectives: Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the... Read More about Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.

Real-time tracking of self-reported symptoms to predict potential COVID-19 (2020)
Journal Article
Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., …Spector, T. D. (2020). Real-time tracking of self-reported symptoms to predict potential COVID-19. Nature Medicine, https://doi.org/10.1038/s41591-020-0916-2

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those w... Read More about Real-time tracking of self-reported symptoms to predict potential COVID-19.

Investigating musculoskeletal health and wellbeing; A cohort study protocol (2020)
Journal Article
Millar, B., McWilliams, D. F., Abhishek, A., Akin-Akinyosoye, K., Auer, D. P., Chapman, V., …Walsh, D. A. (2020). Investigating musculoskeletal health and wellbeing; A cohort study protocol. BMC Musculoskeletal Disorders, 21(1), https://doi.org/10.1186/s12891-020-03195-4

© 2020 The Author(s). Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Heal... Read More about Investigating musculoskeletal health and wellbeing; A cohort study protocol.

First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis (2019)
Journal Article
Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Zhang, H., Wu, X., …the International Ovulation Induction IPDMA Collaboration, . (2019). First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update, 25(6), 717-732. https://doi.org/10.1093/humupd/dmz029

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of anovulatory infertility. In women with PCOS, effective ovulation induction serves as an important first-line treatment for anovulatory infertility. Individual participant data... Read More about First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma (2019)
Journal Article
Sabnis, D. H., Storer, L. C. D., Liu, J., Jackson, H. K., Kilday, J. P., Grundy, R. G., …Coyle, B. (2019). A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. Scientific Reports, 9(1), 1-9. https://doi.org/10.1038/s41598-019-46700-z

© 2019, The Author(s). Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expres... Read More about A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study (2019)
Journal Article
Du, L., Wenning, L. A., Carvalho, B., Duley, L., Brookfield, K. F., Witjes, H., …Oladapo, O. T. (2019). Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study. Journal of Clinical Pharmacology, https://doi.org/10.1002/jcph.1448

Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study w... Read More about Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study.

Study-based registers reduce waste in systematic reviewing: discussion and case report (2019)
Journal Article
Shokraneh, F., & Adams, C. E. (2019). Study-based registers reduce waste in systematic reviewing: discussion and case report. Systematic Reviews, 8(1), https://doi.org/10.1186/s13643-019-1035-3

Background Maintained study-based registers (SBRs) have, at their core, study records linked to, potentially, multiple other records such as references, data sets, standard texts and full-text reports. Such registers can minimise and refine searchin... Read More about Study-based registers reduce waste in systematic reviewing: discussion and case report.

Effects of tinnitus on cochlear implant programming (2019)
Journal Article
Pierzycki, R. H., Corner, C., Fielden, C. A., & Kitterick, P. T. (2019). Effects of tinnitus on cochlear implant programming. Trends in Hearing, 23, https://doi.org/10.1177/2331216519836624

Clinical observations suggest that tinnitus may interfere with programming cochlear implants (CIs), the process of optimizing the transmission of acoustic information to support speech perception with a CI. Despite tinnitus being highly prevalent amo... Read More about Effects of tinnitus on cochlear implant programming.

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses (2019)
Journal Article
Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J., …Williamson, C. (2019). Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet, 393(10174), 899-909. https://doi.org/10.1016/s0140-6736%2818%2931877-4

Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic... Read More about Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses.

Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema (2019)
Journal Article
Howells, L., Thomas, K. S., Sears, A. V., Nasr, I., Wollenberg, A., Schuttelaar, M. L., …Chalmers, J. R. (2019). Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132. https://doi.org/10.1111/jdv.15475

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients’ health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that “long-term control of eczema”... Read More about Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema.

Discrimination of gain increments in speech-shaped noises (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. (2019). Discrimination of gain increments in speech-shaped noises. Trends in Hearing, 23, 1-12. https://doi.org/10.1177/2331216518820220

Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To... Read More about Discrimination of gain increments in speech-shaped noises.

Glutamate dehydrogenase (GLUD1) expression in breast cancer (2018)
Journal Article
Craze, M. L., El-Ansari, R., Aleskandarany, M. A., Cheng, K. W., Al-Farsi, L., Masisi, B., …Green, A. R. (2019). Glutamate dehydrogenase (GLUD1) expression in breast cancer. Breast Cancer Research and Treatment, 174(1), 79–91

Dysregulated cellular metabolism is regarded as one of the hallmarks of cancer with some tumours utilising the glutamine metabolism pathway for their sustained proliferation and survival. Glutamate dehydrogenase (GLUD1) is a key enzyme in glutaminoly... Read More about Glutamate dehydrogenase (GLUD1) expression in breast cancer.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders? (2018)
Journal Article
Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. doi:10.1016/j.coph.2018.08.008

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on... Read More about Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?.

Variation in visiting and isolation policies in neonatal units: a UK nationwide survey (2017)
Journal Article
Tan, S., Clarkson, M., & Sharkey, D. (in press). Variation in visiting and isolation policies in neonatal units: a UK nationwide survey. Pediatric Infectious Disease Journal, doi:10.1097/INF.0000000000001820

Global pandemics, such as H1N1, are a major risk for neonatal patients. We surveyed UK tertiary and district neonatal units about visiting and infection control policies relating to viral respiratory infections. There was marked variation with visiti... Read More about Variation in visiting and isolation policies in neonatal units: a UK nationwide survey.

A systematic review of approaches for calculating the cost of medication errors (2016)
Journal Article
Patel, K., Jay, R., Shahzad, M. W., Green, W., & Patel, R. (2016). A systematic review of approaches for calculating the cost of medication errors. European Journal of Hospital Pharmacy, 23(5), 294-301. https://doi.org/10.1136/ejhpharm-2016-000915

© 2016 Published by the BMJ Publishing Group Limited. Introduction: Although medication errors may cause significant morbidity and mortality, the true cost of avoidable harm from such errors is unclear. While studies describe different methods for ca... Read More about A systematic review of approaches for calculating the cost of medication errors.

The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study (2013)
Journal Article
Mahran, A., Abdelmeged, A., El-Adawy, A. R., Eissa, M. K., Shaw, R. W., & Amer, S. A. (2013). The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study. Journal of Clinical Endocrinology and Metabolism, 98(10), 4170-4175. https://doi.org/10.1210/jc.2013-2193

CONTEXT: Elevated serum anti-Müllerian hormone (AMH) concentration in women with polycystic ovarian syndrome (PCOS) is known to lower sensitivity of ovarian follicles to circulating FSH. This effect may compromise the outcome of clomiphene citrate (... Read More about The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study.



;