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Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma (2023)
Journal Article
Burrows, L., Sculthorpe, D., Zhang, H., Rehman, O., Mukherjee, A., & Chen, K. (2024). Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma. Journal of Pathology Informatics, 15, Article 100351. https://doi.org/10.1016/j.jpi.2023.100351

Whilst automated analysis of immunostains in pathology research has focused predominantly on the epithelial compartment, automated analysis of stains in the stromal compartment is challenging and therefore requires time-consuming pathological input a... Read More about Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma.

Socio-Technical Trust For Multi-Modal Hearing Assistive Technology (2023)
Conference Proceeding
Williams, J., Azim, T., Piskopani, A. M., Chamberlain, A., & Zhang, S. (2023). Socio-Technical Trust For Multi-Modal Hearing Assistive Technology. In IEEE ICASSPW 2023 Workshop Proceedings. https://doi.org/10.1109/ICASSPW59220.2023.10193586

The landscape of opportunity is rapidly changing for audio-visual (AV) hearing assistive technology. While hearing assistive devices, such as hearing aids, have traditionally been developed for populations of deaf and hard of hearing (DHH) communitie... Read More about Socio-Technical Trust For Multi-Modal Hearing Assistive Technology.

Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs (2022)
Journal Article
Ayre, J., Redmond, J. M., Vitulli, G., Tomlinson, L., Weaver, R., Comeo, E., …Stocks, M. J. (2022). Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs. Journal of Medicinal Chemistry, 65(14), 9802-9818. https://doi.org/10.1021/acs.jmedchem.2c00416

A major limitation of pulmonary delivery is that drugs can exhibit suboptimal pharmacokinetic profiles resulting from rapid elimination from the pulmonary tissue. This can lead to systemic side effects and a short duration of action. A series of diba... Read More about Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs.

The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research (2022)
Working Paper
Gladman, Logan, Gordon, Harwood, Goldberg, & Radford. (0000). The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research

It is with pleasure that we present this brochure outlining the work of the Centre for Rehabilitation and Ageing and Research (CRAR) at the University of Nottingham and its partner NHS Trusts in Nottingham, and Derby and Burton.

Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging (2020)
Journal Article
Kendrick, E., Bray, J. M., Doswell, C. L., Pavlovskaya, G. E., Chen, L., Kishore, B., …Britton, M. M. (2020). Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging. Nature Communications, 11(1), Article 2083. https://doi.org/10.1038/s41467-020-15938-x

© 2020, The Author(s). Sodium-ion batteries are a promising battery technology for their cost and sustainability. This has led to increasing interest in the development of new sodium-ion batteries and new analytical methods to non-invasively, directl... Read More about Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging.

Co-creation of Virtual Reality Re-Usable Learning objectives for 360° video scenarios for the surgical excision of skin lesion (2019)
Presentation / Conference
Neokleous, K., Gkougkoudi, E., Hatziaros, M., Schiza, E., Matsangidou, M., Avramides, M., …Pattichis, C. (2019, May). Co-creation of Virtual Reality Re-Usable Learning objectives for 360° video scenarios for the surgical excision of skin lesion. Poster presented at IEEE International Conference on Biomedical and Health Informatics (BHI'19), Dorin Forum, University of Illinois at Chicago, Chicago, IL, USA

This short paper describes an educational scenario using a 360° video for the surgical excision of a skin lesion. This scenario, developed in the context of the CoViRR Erasmus+ project, offering new insights for the digital integration in learning an... Read More about Co-creation of Virtual Reality Re-Usable Learning objectives for 360° video scenarios for the surgical excision of skin lesion.

The Schistosoma mansoni cyclophilin A epitope 107-121 induces a protective immune response against schistosomiasis (2019)
Journal Article
de Melo, T. T., Mendes, M. M., Alves, C. C., Carvalho, G. B., Fernandes, V. C., Pimenta, D. L. F., …Fonseca, C. T. (2019). The Schistosoma mansoni cyclophilin A epitope 107-121 induces a protective immune response against schistosomiasis. Molecular Immunology, 111, 172-181. https://doi.org/10.1016/j.molimm.2019.04.021

Great efforts have been made to identify promising antigens and vaccine formulations against schistosomiasis. Among the previously described Schistosoma vaccine candidates, cyclophilins comprise an interesting antigen that could be used for vaccine f... Read More about The Schistosoma mansoni cyclophilin A epitope 107-121 induces a protective immune response against schistosomiasis.

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis (2018)
Journal Article
Mbanefo, E. C., Le, L., Pennington, L. F., Odegaard, J. I., Jardetzky, T. S., Alouffi, A., …Hsieh, M. H. (2018). Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. FASEB Journal, 32(8), 4408-4419. https://doi.org/10.1096/fj.201701415r

Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized th... Read More about Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.

Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation (2017)
Journal Article
Ueda, Y., Mohammed, I., Song, D., Gullipalli, D., Zhou, L., Sato, S., …Song, W. (2017). Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood, 129(9), 1184-1196. https://doi.org/10.1182/blood-2016-07-728253

Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the c... Read More about Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.