Skip to main content

Research Repository

Advanced Search

All Outputs (1303)

Ant colony optimisation of a community pharmacy dispensing process using Coloured Petri-Net simulation and UK pharmacy in-field data (2022)
Journal Article
Naybour, M. T., Remenyte-Prescott, R., & Boyd, M. (2024). Ant colony optimisation of a community pharmacy dispensing process using Coloured Petri-Net simulation and UK pharmacy in-field data. Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, 238(1), 29-43. https://doi.org/10.1177/1748006X221135459

There are 11,619 community pharmacies in England which dispense over 1 billion prescriptions each year, providing essential primary care to NHS (National Health Service) patients. These pharmacies are facing pressure from a number of sources includin... Read More about Ant colony optimisation of a community pharmacy dispensing process using Coloured Petri-Net simulation and UK pharmacy in-field data.

Development of p-Tau Differentiated Cell Model of Alzheimer’s Disease to Screen Novel Acetylcholinesterase Inhibitors (2022)
Journal Article
Uras, G., Li, X., Manca, A., Pantaleo, A., Bo, M., Xu, J., …Zhu, Z. (2022). Development of p-Tau Differentiated Cell Model of Alzheimer’s Disease to Screen Novel Acetylcholinesterase Inhibitors. International Journal of Molecular Sciences, 23(23), Article 14794. https://doi.org/10.3390/ijms232314794

Alzheimer’s disease (AD) is characterized by an initial accumulation of amyloid plaques and neurofibrillary tangles, along with the depletion of cholinergic markers. The currently available therapies for AD do not present any disease-modifying effect... Read More about Development of p-Tau Differentiated Cell Model of Alzheimer’s Disease to Screen Novel Acetylcholinesterase Inhibitors.

Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study (2022)
Journal Article
Anderson, C., Iqbal, A., Knaggs, R., & Toh, L. S. (2023). Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study. International Journal of Clinical Pharmacy, 45, 220-232. https://doi.org/10.1007/s11096-022-01493-6

Background Opioids are commonly used for the management of chronic non-malignant pain in Pakistan; but there is a lack of literature around precursors or motivators in the use of opioids. Aim The study holistically explored factors contributing towa... Read More about Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study.

Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site (2022)
Journal Article
Muresan, P., McCrorie, P., Smith, F., Vasey, C., Taresco, V., Scurr, D. J., …Marlow, M. (2023). Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. European Journal of Pharmaceutics and Biopharmaceutics, 182, 53-61. https://doi.org/10.1016/j.ejpb.2022.11.016

Systemic drug delivery to the central nervous system (CNS) has been historically impeded by the presence of the blood brain barrier rendering many therapies inefficacious to any cancer cells residing within the brain. Therefore, local drug delivery s... Read More about Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site.

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells (2022)
Journal Article
Comez, D., Glenn, J., Anbuhl, S. M., Heukers, R., Smit, M. J., Hill, S. J., & Kilpatrick, L. E. (2022). Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells. Frontiers in Immunology, 13, Article 1006718. https://doi.org/10.3389/fimmu.2022.1006718

Introduction: The Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in vari... Read More about Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells.

Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study (2022)
Journal Article
Rodgers, S., Taylor, A. C., Roberts, S. A., Allen, T., Ashcroft, D. M., Barrett, J., …Avery, A. J. (2022). Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study. PLoS Medicine, 19(11), Article e1004133. https://doi.org/10.1371/journal.pmed.1004133

Background: We previously reported on a randomised trial demonstrating the effectiveness and cost-effectiveness of a pharmacist-led information technology intervention (PINCER). We sought to investigate whether PINCER was effective in reducing hazard... Read More about Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study.

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease (2022)
Journal Article
Li, X., Li, T., Zhan, F., Cheng, F., Lu, L., Zhang, B., …Yao, H. (2022). Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chemical Neuroscience, 13(23), 3488-3501. https://doi.org/10.1021/acschemneuro.2c00520

Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited signific... Read More about Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease (2022)
Journal Article
Dwomoh, L., Rossi, M., Scarpa, M., Khajehali, E., Molloy, C., Herzyk, P., …Tobin, A. B. (2022). M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. Science Signaling, 15(760), 00. https://doi.org/10.1126/scisignal.abm3720

Many dementias are propagated through the spread of “prion-like” misfolded proteins. This includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer’s disease (AD), for which no treatments are available to slow or stop progr... Read More about M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.

Direct routes to functional RAFT agents from substituted N-alkyl maleimides (2022)
Journal Article
Catania, R., Foralosso, R., Spanos, L., Russo, E., Mastrotto, F., Gurnani, P., …Mantovani, G. (2022). Direct routes to functional RAFT agents from substituted N-alkyl maleimides. Polymer Chemistry, 13(45), 6261-6267. https://doi.org/10.1039/d1py01565f

N-substituted maleimides have become an indispensable tool for the synthesis of bioconjugates and functional materials. Herein, we present three strategies for the incorporation of N-alkyl substituted maleimides into RAFT agents and show that these m... Read More about Direct routes to functional RAFT agents from substituted N-alkyl maleimides.

Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases (2022)
Book Chapter
Spiliotopoulos, A., Maurer, S. K., Tsoumpeli, M. T., Bonfante, J. A. F., Owen, J. P., Gough, K. C., & Dreveny, I. (2023). Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases. In J. Maupin-Furlow, & M. J. Edelmann (Eds.), Deubiquitinases: Methods and Protocols (189-218). Humana Press. https://doi.org/10.1007/978-1-0716-2803-4_12

Phage display (PD) is a powerful method and has been extensively used to generate monoclonal antibodies and identify epitopes, mimotopes, and protein interactions. More recently, the combination of next-generation sequencing (NGS) with PD (NGPD) has... Read More about Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases.

Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers (2022)
Journal Article
Mehradnia, F., Moloney, C., Cavanagh, R., Pearce, A. K., Ritchie, A., Clarke, P., …Alexander, C. (2022). Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers. British Journal of Pharmacy, 7(2), https://doi.org/10.5920/bjpharm.1173

The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like... Read More about Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers.

The effect of Amine modification on siRNA delivery of redox-responsive PEGylated amphiphilic micellar nanoparticles for triple negative breast cancer therapy (2022)
Journal Article
Mehradnia, F., & Alexander, C. (2022). The effect of Amine modification on siRNA delivery of redox-responsive PEGylated amphiphilic micellar nanoparticles for triple negative breast cancer therapy. British Journal of Pharmacy, 7(2), https://doi.org/10.5920/bjpharm.1119

We developed a set of methoxypoly(ethyleneglycol)-co-poly(N3-ε-caprolactone) (mPEG-N3PCL)copolymers with different types of amine linkers and investigated thecontribution of the introduced amino linker to the gene delivery efficiency ofnanoparticles.... Read More about The effect of Amine modification on siRNA delivery of redox-responsive PEGylated amphiphilic micellar nanoparticles for triple negative breast cancer therapy.

Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid (2022)
Journal Article
Salinas, A., McGregor, C., Irorere, V., Arenas-López, C., Bommareddy, R. R., Winzer, K., …Kovács, K. (2022). Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid. Metabolic Engineering, 74, 178-190. https://doi.org/10.1016/j.ymben.2022.10.014

3-Hydroxypropionate (3-HP) is a versatile compound for chemical synthesis and a potential building block for biodegradable polymers. Cupriavidus necator H16, a facultative chemolithoautotroph, is an attractive production chassis and has been extensiv... Read More about Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid.

Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling (2022)
Journal Article
Olubi, R., Small, W., Burley, J., & Bosquillon, C. (2022). Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling. British Journal of Pharmacy, 7(2), S1-S2. https://doi.org/10.5920/bjpharm.1140

The aim of this study was to optimise processing parameters in the preparation ofbudesonide nanocrystals by a miniature media milling process performed at labscale. Using Polysorbate 80 as the surfactant choice of stabilizer, the effectof milling bea... Read More about Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling.

Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings (2022)
Journal Article
Eltaher, H. M., Blokpoel Ferreras, L. A., Jalal, A. R., & Dixon, J. (2022). Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings. Biomaterials Advances, 143, Article 213177. https://doi.org/10.1016/j.bioadv.2022.213177

Nanotechnologies are being increasingly applied as systems for peptide and nucleic acid macromolecule drug delivery. However systemic targeting of these, or efficient topical and localized delivery remains an issue. A controlled release system that c... Read More about Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings.

Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models (2022)
Journal Article
He, W., Cardoso, A. S., Hyde, R. M., Green, M. J., Scurr, D. J., Griffiths, R., …Kim, D. (2022). Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models. Analyst, 147(23), 5537-5545. https://doi.org/10.1039/d2an01520j

Lameness is a major challenge in the dairy cattle industry in terms of animal welfare and economic implications. Better understanding of metabolic alteration associated with lameness could lead to early diagnosis and effective treatment{,} there-fore... Read More about Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models.

Synthetic Biology Toolbox, Including a Single-Plasmid CRISPR-Cas9 System to Biologically Engineer the Electrogenic, Metal-Resistant Bacterium Cupriavidus metallidurans CH34 (2022)
Journal Article
Turco, F., Garavaglia, M., Van Houdt, R., Hill, P., Rawson, F. J., & Kovacs, K. (2022). Synthetic Biology Toolbox, Including a Single-Plasmid CRISPR-Cas9 System to Biologically Engineer the Electrogenic, Metal-Resistant Bacterium Cupriavidus metallidurans CH34. ACS Synthetic Biology, https://doi.org/10.1021/acssynbio.2c00130

Cupriavidus metallidurans CH34 exhibits extraordinary metabolic versatility, including chemolithoautotrophic growth; degradation of BTEX (benzene, toluene, ethylbenzene, xylene); high resistance to numerous metals; biomineralization of gold, platinum... Read More about Synthetic Biology Toolbox, Including a Single-Plasmid CRISPR-Cas9 System to Biologically Engineer the Electrogenic, Metal-Resistant Bacterium Cupriavidus metallidurans CH34.

Electric field responsive nanotransducers for glioblastoma (2022)
Journal Article
Jain, A., Jobson, I., Griffin, M., Rahman, R., Smith, S., & Rawson, F. J. (2022). Electric field responsive nanotransducers for glioblastoma. Bioelectronic Medicine, 8, Article 17. https://doi.org/10.1186/s42234-022-00099-7

Background Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTFields rely on alternating curre... Read More about Electric field responsive nanotransducers for glioblastoma.

How interprofessional education is offered to pharmacists and pharmacy students: A scoping review (2022)
Journal Article
Machado, A. C., Czock, A., Boone, J., Anderson, C., & Leite, S. N. (2022). How interprofessional education is offered to pharmacists and pharmacy students: A scoping review. Journal of Interprofessional Education & Practice, 29, Article 100563. https://doi.org/10.1016/j.xjep.2022.100563

This study presents a review of recent published experiences of Interprofessional Education (IPE) in pharmacy education, aiming to identify the educational, institutional, and systemic factors involved in their development. Six databases were searche... Read More about How interprofessional education is offered to pharmacists and pharmacy students: A scoping review.