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Direct routes to functional RAFT agents from substituted N-alkyl maleimides

Catania, Rosa; Foralosso, Ruggero; Spanos, Lampros; Russo, Emanuele; Mastrotto, Francesca; Gurnani, Pratik; Butler, Kevin; Williams, Huw; Stolnik, Snow; Mantovani, Giuseppe

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Rosa Catania

Ruggero Foralosso

Lampros Spanos

Emanuele Russo

Francesca Mastrotto

Pratik Gurnani

Kevin Butler

Senior Research Fellow

Snow Stolnik


N-substituted maleimides have become an indispensable tool for the synthesis of bioconjugates and functional materials. Herein, we present three strategies for the incorporation of N-alkyl substituted maleimides into RAFT agents and show that these maleimide-derived CTAs can be used to easily introduce a range of chemical functionality at the β-position of polymer chains, resulting in α,β,ω-functional RAFT polymers. With both functional maleimides and RAFT agents that are increasingly available on the market, the approach presented in this study could facilitate the synthesis of end-functional macromolecules and will complement well the range of existing synthetic routes, including those utilising N-substituted maleimides, to functional polymeric materials.

Journal Article Type Article
Acceptance Date Oct 26, 2022
Online Publication Date Nov 14, 2022
Publication Date Dec 7, 2022
Deposit Date Nov 30, 2022
Publicly Available Date Dec 2, 2022
Journal Polymer Chemistry
Print ISSN 1759-9954
Electronic ISSN 1759-9962
Publisher Royal Society of Chemistry (RSC)
Peer Reviewed Peer Reviewed
Volume 13
Issue 45
Pages 6261-6267
Keywords Organic Chemistry; Polymers and Plastics; Biochemistry; Bioengineering
Public URL
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