Direct routes to functional RAFT agents from substituted N-alkyl maleimides

Catania, Rosa; Foralosso, Ruggero; Spanos, Lampros; Russo, Emanuele; Mastrotto, Francesca; Gurnani, Pratik; Butler, Kevin; Williams, Huw; Stolnik, Snow; Mantovani, Giuseppe

Abstract

N-substituted maleimides have become an indispensable tool for the synthesis of bioconjugates and functional materials. Herein, we present three strategies for the incorporation of N-alkyl substituted maleimides into RAFT agents and show that these maleimide-derived CTAs can be used to easily introduce a range of chemical functionality at the β-position of polymer chains, resulting in α,β,ω-functional RAFT polymers. With both functional maleimides and RAFT agents that are increasingly available on the market, the approach presented in this study could facilitate the synthesis of end-functional macromolecules and will complement well the range of existing synthetic routes, including those utilising N-substituted maleimides, to functional polymeric materials.

Citation

Catania, R., Foralosso, R., Spanos, L., Russo, E., Mastrotto, F., Gurnani, P., Butler, K., Williams, H., Stolnik, S., & Mantovani, G. (2022). Direct routes to functional RAFT agents from substituted N-alkyl maleimides. Polymer Chemistry, 13(45), 6261-6267. https://doi.org/10.1039/d1py01565f

• Journal Article Type: Article
• Acceptance Date: Oct 26, 2022
• Online Publication Date: Nov 14, 2022
• Publication Date: Dec 7, 2022
• Deposit Date: Nov 30, 2022
• Publicly Available Date: Dec 2, 2022
• Journal: Polymer Chemistry
• Print ISSN: 1759-9954
• Electronic ISSN: 1759-9962
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 45
• Pages: 6261-6267
• DOI: https://doi.org/10.1039/d1py01565f
• Keywords: Organic Chemistry; Polymers and Plastics; Biochemistry; Bioengineering
• Public URL: https://nottingham-repository.worktribe.com/output/13754751
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2022/PY/D1PY01565F