Skip to main content

Research Repository

Advanced Search

Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers

Mehradnia, Fatemeh; Moloney, Cara; Cavanagh, Robert; Pearce, Amanda K; Ritchie, Alison; Clarke, Philip; Rahman, Ruman; Ibrahim, Asmaa; Grabowskab, Anna M.; Alexander, Cameron

Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers Thumbnail


Authors

Fatemeh Mehradnia

Amanda K Pearce

Alison Ritchie

Philip Clarke

Asmaa Ibrahim

ANNA GRABOWSKA ANNA.GRABOWSKA@NOTTINGHAM.AC.UK
Professor of Cancer Microenvironment



Abstract

The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs) based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.

Journal Article Type Article
Acceptance Date Jul 4, 2022
Online Publication Date Nov 4, 2022
Publication Date Nov 4, 2022
Deposit Date Dec 14, 2022
Publicly Available Date Dec 14, 2022
Journal 2022 APS Special Issue
Electronic ISSN 2058-8356
Publisher University of Huddersfield Press
Peer Reviewed Peer Reviewed
Volume 7
Issue 2
DOI https://doi.org/10.5920/bjpharm.1173
Keywords General Medicine
Public URL https://nottingham-repository.worktribe.com/output/14888006
Publisher URL https://www.bjpharm.org.uk/article/id/1173/
Additional Information Proceedings of the 13th APS International PharmSci 2022

Files





You might also like



Downloadable Citations