Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers

Mehradnia, Fatemeh; Moloney, Cara; Cavanagh, Robert; Pearce, Amanda K; Ritchie, Alison; Clarke, Philip; Rahman, Ruman; Ibrahim, Asmaa; Grabowskab, Anna M.; Alexander, Cameron

doi:10.5920/bjpharm.1173

Authors

Fatemeh Mehradnia

CARA MOLONEY CARA.MOLONEY@NOTTINGHAM.AC.UK
Research Fellow

ROBERT CAVANAGH ROBERT.CAVANAGH1@NOTTINGHAM.AC.UK
Research Fellow

Amanda K Pearce

Alison Ritchie

Philip Clarke

RUMAN RAHMAN RUMAN.RAHMAN@NOTTINGHAM.AC.UK
Associate Professor

Asmaa Ibrahim

ANNA GRABOWSKA anna.grabowska@nottingham.ac.uk
Professor of Cancer Microenvironment

Professor CAMERON ALEXANDER cameron.alexander@nottingham.ac.uk
Professor of Polymer Therapeutics

Abstract

The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs) based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.

Citation

Mehradnia, F., Moloney, C., Cavanagh, R., Pearce, A. K., Ritchie, A., Clarke, P., …Alexander, C. (2022). Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers. British Journal of Pharmacy, 7(2), https://doi.org/10.5920/bjpharm.1173

Journal Article Type	Article
Acceptance Date	Jul 4, 2022
Online Publication Date	Nov 4, 2022
Publication Date	Nov 4, 2022
Deposit Date	Dec 14, 2022
Publicly Available Date	Dec 14, 2022
Journal	British Journal of Pharmacy
Print ISSN	2058-8356
Electronic ISSN	2058-8356
Publisher	University of Huddersfield Press
Peer Reviewed	Peer Reviewed
Volume	7
Issue	2
DOI	https://doi.org/10.5920/bjpharm.1173
Keywords	General Medicine
Public URL	https://nottingham-repository.worktribe.com/output/14888006
Publisher URL	https://www.bjpharm.org.uk/article/id/1173/
Additional Information	Proceedings of the 13th APS International PharmSci 2022

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