Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers

Mehradnia, Fatemeh; Moloney, Cara; Cavanagh, Robert; Pearce, Amanda K; Ritchie, Alison; Clarke, Philip; Rahman, Ruman; Ibrahim, Asmaa; Grabowskab, Anna M.; Alexander, Cameron

Abstract

The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs) based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.

Citation

Mehradnia, F., Moloney, C., Cavanagh, R., Pearce, A. K., Ritchie, A., Clarke, P., …Alexander, C. (2022). Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers. British Journal of Pharmacy, 7(2), https://doi.org/10.5920/bjpharm.1173

• Journal Article Type: Article
• Acceptance Date: Jul 4, 2022
• Online Publication Date: Nov 4, 2022
• Publication Date: Nov 4, 2022
• Deposit Date: Dec 14, 2022
• Publicly Available Date: Dec 14, 2022
• Journal: 2022 APS Special Issue
• Electronic ISSN: 2058-8356
• Publisher: University of Huddersfield Press
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 2
• DOI: https://doi.org/10.5920/bjpharm.1173
• Keywords: General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/14888006
• Publisher URL: https://www.bjpharm.org.uk/article/id/1173/
• Additional Information: Proceedings of the 13th APS International PharmSci 2022