All Outputs (128)

A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays (2015)
Journal Article

Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum and insoluble components suc... Read More about A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays.

Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging (2015)
Journal Article

Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiar... Read More about Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging.

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation (2015)
Journal Article

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial... Read More about Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.

Authentication of processed meat products by peptidomic analysis using rapid ambient mass spectrometry (2015)
Journal Article

We present the application of a novel ambient LESA-MS method for the authentication of processed meat products. A set of 25 species and protein-specific heat stable peptide markers has been detected in processed samples manufactured from beef, pork,... Read More about Authentication of processed meat products by peptidomic analysis using rapid ambient mass spectrometry.

Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry (2015)
Journal Article

Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption (2015)
Journal Article

The complexity of hyperspectral time of flight secondary ion mass spectrometry (ToF-SIMS) datasets makes their subsequent analysis and interpretation challenging, and is often an impasse to the identification of trends and differences within large sa... Read More about Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption.

3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling (2015)
Journal Article

ToF-SIMS imaging with argon cluster sputter depth profiling has provided detailed insight into the three-dimensional (3D) chemical composition of a series of polymer multilayer structures. Depths of more than 15 μm were profiled in these samples whil... Read More about 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling.

Impact of surface chemistry and topography on the function of antigen presenting cells (2015)
Journal Article

Antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs) play a crucial role in orchestrating immune responses against foreign materials. The activation status of APCs can determine the outcome of an immune response following imp... Read More about Impact of surface chemistry and topography on the function of antigen presenting cells.

Materiomics: a toolkit for developing new biomaterials (2015)
Book Chapter

Learning Objectives • To understand the what materiomics is and why it is required • To become familiar with the various approaches used to design materiomic experiments • To learn what a polymer microarray is, what it is used for and how it is pr... Read More about Materiomics: a toolkit for developing new biomaterials.

Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity (2014)
Journal Article

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria i... Read More about Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity.

Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry (2014)
Journal Article

In this paper, our previously developed ambient LESA-MS methodology is implemented to analyze five types of thermally treated meat species, namely beef, pork, horse, chicken, and turkey meat, in order to select and identify heat-stable and species-sp... Read More about Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry.

High throughput screening for biomaterials discovery (2014)
Journal Article

Using microarray technologies thousands of biomedical materials can be screened in a rapid, parallel and cost effective fashion to identify the optimum candidate that fulfils a specific biomedical application. High throughput surface characterization... Read More about High throughput screening for biomaterials discovery.

Materials for stem cell factories of the future (2014)
Journal Article

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking a... Read More about Materials for stem cell factories of the future.

Tryptic Digestion Coupled with Ambient Desorption Electrospray Ionization and Liquid Extraction Surface Analysis Mass Spectrometry Enabling Identification of Skeletal Muscle Proteins in Mixtures and Distinguishing between Beef, Pork, Horse, Chicken, and Turkey Meat (2014)
Journal Article

The use of ambient desorption electrospray ionization (DESI-MS) mass spectrometry and liquid extraction surface analysis mass spectrometry (LESA-MS) is explored for the first time to analyse skeletal muscle proteins obtained from mixture of standard... Read More about Tryptic Digestion Coupled with Ambient Desorption Electrospray Ionization and Liquid Extraction Surface Analysis Mass Spectrometry Enabling Identification of Skeletal Muscle Proteins in Mixtures and Distinguishing between Beef, Pork, Horse, Chicken, and Turkey Meat.

Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment (2014)
Journal Article

The thermally triggered release of up to 96% of attached uropathogenic E. coli is achieved on two polymers with opposite changes in surface wettability upon reduction in temperature. This demonstrates that the bacterial attachment to a surface cannot... Read More about Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment.

Modelling and Prediction of Bacterial Attachment to Polymers (2013)
Journal Article

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on mat... Read More about Modelling and Prediction of Bacterial Attachment to Polymers.

Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion (2013)
Journal Article

The detection and identification of proteins adsorbed onto biomaterial surfaces under ambient conditions has significant experimental advantages but has proven to be difficult to achieve with conventional measuring technologies. In this study, we pre... Read More about Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion.

Desktop 3D printing of controlled release pharmaceutical bilayer tablets (2013)
Journal Article

Three dimensional (3D) printing was used as a novel medicine formulation technique for production of viable tablets capable of satisfying regulatory tests and matching the release of standard commercial tablets. Hydroxypropyl methylcellulose (HPMC 22... Read More about Desktop 3D printing of controlled release pharmaceutical bilayer tablets.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry (2013)
Journal Article

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discove... Read More about High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.