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Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity

Sanni, Olutoba; Chang, Chien-Yi; Anderson, Daniel G.; Langer, Robert; Davies, Martyn C.; Williams, Philip M.; Williams, Paul; Alexander, Morgan R.; Hook, Andrew L.

Authors

Olutoba Sanni

Chien-Yi Chang

Daniel G. Anderson

Robert Langer

Martyn C. Davies

PAUL WILLIAMS paul.williams@nottingham.ac.uk
Professor of Molecular Microbiology



Abstract

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly (meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment.

Citation

Sanni, O., Chang, C., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., …Hook, A. L. (2015). Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Advanced Healthcare Materials, 4(5), 695-701. https://doi.org/10.1002/adhm.201400648

Journal Article Type Article
Acceptance Date Nov 19, 2014
Online Publication Date Dec 9, 2014
Publication Date 2015-04
Deposit Date Dec 7, 2017
Publicly Available Date Dec 7, 2017
Journal Advanced Healthcare Materials
Print ISSN 2192-2640
Electronic ISSN 2192-2640
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 4
Issue 5
Pages 695-701
DOI https://doi.org/10.1002/adhm.201400648
Keywords low-fouling; molecular descriptors; polymer microarrays; Pseudomonas aeruginosa ; ion mass spectrometry
Public URL http://eprints.nottingham.ac.uk/id/eprint/48600
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400648/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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