Materials for stem cell factories of the future

Celiz, Adam D.; Smith, James G.W.; Langer, Robert; Anderson, Daniel G.; Barrett, David A.; Winkler, David A.; Davies, Martyn C.; Young, Lorraine E.; Denning, Chris; Alexander, Morgan R.

Abstract

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.

Citation

Celiz, A. D., Smith, J. G., Langer, R., Anderson, D. G., Barrett, D. A., Winkler, D. A., …Alexander, M. R. (2014). Materials for stem cell factories of the future. Nature Materials, 13(6), 570-579. https://doi.org/10.1038/nmat3972

• Journal Article Type: Article
• Acceptance Date: Mar 31, 2014
• Online Publication Date: May 21, 2014
• Publication Date: 2014-06
• Deposit Date: Nov 20, 2015
• Publicly Available Date: Nov 20, 2015
• Journal: Nature Materials
• Print ISSN: 1476-1122
• Electronic ISSN: 1476-4660
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 6
• Pages: 570-579
• DOI: https://doi.org/10.1038/nmat3972
• Keywords: biomaterials, cells, human pluripotent stem cells
• Public URL: https://nottingham-repository.worktribe.com/output/728318
• Publisher URL: https://www.nature.com/articles/nmat3972
• Additional Information: Received: 18 July 2013; Accepted: 31 March 2014; First Online: 21 May 2014; : The authors declare no competing financial interests.