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Materials for stem cell factories of the future

Celiz, Adam D.; Smith, James G.W.; Langer, Robert; Anderson, Daniel G.; Barrett, David A.; Winkler, David A.; Davies, Martyn C.; Young, Lorraine E.; Denning, Chris; Alexander, Morgan R.

Authors

Adam D. Celiz

James G.W. Smith

Robert Langer

Daniel G. Anderson

David A. Barrett

David A. Winkler

Martyn C. Davies

Lorraine E. Young

CHRIS DENNING chris.denning@nottingham.ac.uk
Professor of Stem Cell Biology



Abstract

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.

Citation

Celiz, A. D., Smith, J. G., Langer, R., Anderson, D. G., Barrett, D. A., Winkler, D. A., …Alexander, M. R. (2014). Materials for stem cell factories of the future. Nature Materials, 13(6), 570-579. https://doi.org/10.1038/nmat3972

Journal Article Type Article
Acceptance Date Mar 31, 2014
Online Publication Date May 21, 2014
Publication Date 2014-06
Deposit Date Nov 20, 2015
Publicly Available Date Nov 20, 2015
Journal Nature Materials
Print ISSN 1476-1122
Electronic ISSN 1476-4660
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 13
Issue 6
Pages 570-579
DOI https://doi.org/10.1038/nmat3972
Keywords biomaterials, cells, human pluripotent stem cells
Public URL http://eprints.nottingham.ac.uk/id/eprint/30875
Publisher URL https://www.nature.com/articles/nmat3972
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Received: 18 July 2013; Accepted: 31 March 2014; First Online: 21 May 2014; : The authors declare no competing financial interests.

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Celis, Nature Materials 2015 Materials for the stem cell factories of the future.pdf (1.3 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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