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High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry

Hook, Andrew L.; Scurr, David J.; Anderson, Daniel G.; Langer, Robert; Williams, Paul; Davies, Martyn C.; Alexander, Morgan R.

Authors

Andrew L. Hook

David J. Scurr

Daniel G. Anderson

Robert Langer

Paul Williams

Martyn C. Davies

Morgan R. Alexander Morgan.Alexander@nottingham.ac.uk



Abstract

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred.

Journal Article Type Article
Publication Date Jan 1, 2013
Journal Surface and Interface Analysis
Print ISSN 0142-2421
Electronic ISSN 1096-9918
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 1
APA6 Citation Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. C., & Alexander, M. R. (2013). High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis, 45(1), doi:10.1002/sia.4910
DOI https://doi.org/10.1002/sia.4910
Keywords Thermo-Responsive, Stimuli, Switchable, ToF-SIMS, Water Contact Angle, Polymer Microarray
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/sia.4910/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This is the peer reviewed version of the following article: Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. and Alexander, M. (2013), High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry Surf. Interface Anal., 45: 181–184. doi:10.1002/sia.4910 which has been published in final form at http://onlinelibrary.wi....1002/sia.4910/abstract
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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