All Outputs (46)

Factors associated with change in skin autofluorescence in persons receiving dialysis (2020)
Journal Article

Introduction An increase over time in skin autofluorescence (SAF), a measure of accumulation of advanced glycation end products (AGE), predicts higher mortality on hemodialysis (HD). However, evidence is lacking regarding factors that contribute t... Read More about Factors associated with change in skin autofluorescence in persons receiving dialysis.

SGLT?2 Inhibitor Renal Outcome Modification in Type?2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk (2020)
Journal Article

Data from three completed cardiovascular outcome trials (CVOTs), EMPA?REG OUTCOME, CANVAS Program and DECLARE?TIMI 58, add to the evidence supporting the potential renoprotective effects of sodium?glucose linked transporter?2 (SGLT2) inhibitors in pa... Read More about SGLT?2 Inhibitor Renal Outcome Modification in Type?2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk.

Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study (2020)
Journal Article

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study.

Biological Variation of Cardiac Troponins in Chronic Kidney Disease (2020)
Journal Article

Background Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-... Read More about Biological Variation of Cardiac Troponins in Chronic Kidney Disease.

Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study (2020)
Journal Article

BACKGROUND: In studies including the general population, the presence of non-malignant monoclonal gammopathy (MG) can be causally associated with kidney damage and shorter survival. We assessed whether the presence of an MG is associated with a highe... Read More about Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study.

A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression (2020)
Journal Article

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However,... Read More about A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression.

Validation of the European Renal Best Practice guideline algorithm for management of older patients with advanced chronic kidney disease: a commentary (2019)
Journal Article

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article

Rationale & Objective Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Determinants of change in arterial stiffness over 5 years in early chronic kidney disease (2019)
Journal Article

Background Arterial stiffness is an established and potentially modifiable risk factor for cardiovascular disease, associated with chronic kidney disease. There have been few studies to evaluate progression of arterial stiffness over time or factors... Read More about Determinants of change in arterial stiffness over 5 years in early chronic kidney disease.

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More about Skin autofluorescence: an emerging biomarker in persons with kidney disease.

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More about Chronic Kidney Disease: call for an age-adapted definition.

Peritoneal Ultrafiltration for Heart Failure: Lessons from a Randomised Controlled Trial (2019)
Journal Article

Peritoneal ultrafiltration (PuF) has been employed for severe heart failure (HF), but evidence for its benefit is lacking. The Peritoneal Dialysis for Heart Failure (PDHF) study was a multicenter prospective randomized controlled trial which aimed to... Read More about Peritoneal Ultrafiltration for Heart Failure: Lessons from a Randomised Controlled Trial.

Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease (2019)
Journal Article

Although blood pressure control is a major goal in chronic kidney disease, no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. To evaluate this we compared crude prevalence of uncontrolled blood p... Read More about Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease.

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article

BACKGROUND: Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More about Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging.

Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease (2019)
Journal Article

When assessing changes in glomerular filtration rate (GFR) it is important to differentiate pathological change from intrinsic biological and analytical variation. GFR is measured using complex reference methods (e.g., iohexol clearance). In clinical... Read More about Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease.

Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial (2018)
Journal Article

Background: Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate-to-severe chronic kidney... Read More about Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial.

The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis (2018)
Journal Article

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from hyperglycemia, oxidative stress and systemic inflammation. AGEs are also formed in food during cooking. On the other hand, malnutrition may contribute to AGE formati... Read More about The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis.

What is the value of multidisciplinary care for chronic kidney disease? (2018)
Journal Article

The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study (2017)
Journal Article

© 2017 Shardlow et al. Background: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-bas... Read More about The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study.

Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease (2017)
Journal Article

Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping)... Read More about Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease.