Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study

H�rner, Daniela Viramontes; Willingham, Fiona C.; Selby, Nicholas M.; Taal, Maarten W.

Abstract

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (SAF), a measure of AGE accumulation and risk factor for mortality, than high dietary AGE intake in a hemodialysis (HD) population, suggesting that correcting malnutrition may decrease SAF. Design and methods: We investigated this hypothesis in a single center, non-randomized proof of principle study. We enrolled 27 HD and one peritoneal dialysis (PD) patient with malnutrition who received individualized nutritional advice and support over 6 months. SAF was measured at baseline, 3 and 6 months. Dietary intake and nutritional status were assessed at baseline and 6 months. Results were compared with a control group of malnourished dialysis patients (n= 41 HD and 8 PD) from a previous observational study.

Citation

Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study. Journal of Renal Nutrition, 30(6), 540-547. https://doi.org/10.1053/j.jrn.2019.12.006

• Journal Article Type: Article
• Acceptance Date: Dec 13, 2019
• Online Publication Date: Feb 7, 2020
• Publication Date: Nov 1, 2020
• Deposit Date: Dec 18, 2019
• Publicly Available Date: Feb 8, 2021
• Journal: Journal of Renal Nutrition
• Print ISSN: 1051-2276
• Electronic ISSN: 1532-8503
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 6
• Pages: 540-547
• DOI: https://doi.org/10.1053/j.jrn.2019.12.006
• Keywords: Advanced glycation end-products; dialysis; dietetic intervention; malnutrition; skin autofluorescence
• Public URL: https://nottingham-repository.worktribe.com/output/3596057
• Publisher URL: https://www.jrnjournal.org/article/S1051-2276(19)30430-3/fulltext