Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging

Buchanan, Charlotte E.; Mahmoud, Huda; Cox, Eleanor F.; McCulloch, Thomas; Prestwich, Benjamin L.; Taal, Maarten W.; Selby, Nicholas M.; Francis, Susan T.

Abstract

BACKGROUND:
Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated in chronic kidney disease (CKD).

METHODS:
We performed multi-parametric renal MRI in persons with CKD (n = 22, 61 ± 24 years) who had a renal biopsy and measured glomerular filtration rate (mGFR), and matched healthy volunteers (HV) (n = 22, 61 ± 25 years). Longitudinal relaxation time (T1), diffusion-weighted imaging, renal blood flow (phase contrast MRI), cortical perfusion (arterial spin labelling) and blood-oxygen-level-dependent relaxation rate (R2*) were evaluated.

RESULTS:
MRI evidenced excellent reproducibility in CKD (coefficient of variation 

Citation

Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., Selby, N. M., & Francis, S. T. (2020). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, 35(6), 955-964. https://doi.org/10.1093/ndt/gfz129

• Journal Article Type: Article
• Acceptance Date: May 13, 2019
• Online Publication Date: Jun 29, 2019
• Publication Date: Jun 1, 2020
• Deposit Date: Jul 2, 2019
• Publicly Available Date: Jul 17, 2019
• Journal: Nephrology Dialysis Transplantation
• Print ISSN: 0931-0509
• Electronic ISSN: 1460-2385
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 6
• Pages: 955-964
• DOI: https://doi.org/10.1093/ndt/gfz129
• Keywords: Nephrology; Transplantation
• Public URL: https://nottingham-repository.worktribe.com/output/2258080
• Publisher URL: https://academic.oup.com/ndt/article/35/6/955/5525254
• Contract Date: Jul 17, 2019