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Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease

Cox, Eleanor F.; Buchanan, Charlotte E.; Bradley, Christopher R.; Prestwich, Benjamin; Mahmoud, Huda; Taal, Maarten; Selby, Nicholas M.; Francis, Susan T.

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Authors

ELEANOR COX ELEANOR.COX@NOTTINGHAM.AC.UK
Senior Research Fellow

Benjamin Prestwich

Huda Mahmoud



Abstract

Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping).

Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2*, diffusion (ADC, D, D*, fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1.5 T vs. 3 T) dependence of T1 and T2* relaxation times; (2) the repeatability of multiparametric MRI measures in 11 healthy participants; (3) changes in MRI measures in response to hypercapnic and hyperoxic modulations in six healthy participants; and (4) pilot data showing the application of the multiparametric protocol in 11 patients with Chronic Kidney Disease (CKD).

Results: Baseline measures were in-line with literature values, and as expected, T1-values were longer at 3 T compared with 1.5 T, with increased T1 corticomedullary differentiation at 3 T. Conversely, T2* was longer at 1.5 T. Inter-scan coefficients of variation (CoVs) of T1 mapping and ADC were very good at

Citation

Cox, E. F., Buchanan, C. E., Bradley, C. R., Prestwich, B., Mahmoud, H., Taal, M., …Francis, S. T. (2017). Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease. Frontiers in Physiology, 8, Article 696. https://doi.org/10.3389/fphys.2017.00696

Journal Article Type Article
Acceptance Date Aug 30, 2017
Publication Date Sep 14, 2017
Deposit Date Sep 14, 2017
Publicly Available Date Sep 14, 2017
Journal Frontiers in Physiology
Electronic ISSN 1664-042X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Article Number 696
DOI https://doi.org/10.3389/fphys.2017.00696
Keywords magnetic resonance imaging, hemodynamics, oxygenation, renal function, arterial spin labeling
Public URL https://nottingham-repository.worktribe.com/output/882915
Publisher URL http://journal.frontiersin.org/article/10.3389/fphys.2017.00696/full

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