Eleanor F. Cox
Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease
Cox, Eleanor F.; Buchanan, Charlotte E.; Bradley, Christopher R.; Prestwich, Benjamin; Mahmoud, Huda; Taal, Maarten; Selby, Nicholas M.; Francis, Susan T.
Charlotte E. Buchanan
Christopher R. Bradley
Huda Mahmoud Huda.Mahmoud@nottingham.ac.uk
Nicholas M. Selby
Susan T. Francis
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping).
Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2*, diffusion (ADC, D, D*, fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1.5 T vs. 3 T) dependence of T1 and T2* relaxation times; (2) the repeatability of multiparametric MRI measures in 11 healthy participants; (3) changes in MRI measures in response to hypercapnic and hyperoxic modulations in six healthy participants; and (4) pilot data showing the application of the multiparametric protocol in 11 patients with Chronic Kidney Disease (CKD).
Results: Baseline measures were in-line with literature values, and as expected, T1-values were longer at 3 T compared with 1.5 T, with increased T1 corticomedullary differentiation at 3 T. Conversely, T2* was longer at 1.5 T. Inter-scan coefficients of variation (CoVs) of T1 mapping and ADC were very good at
|Journal Article Type||Article|
|Publication Date||Sep 14, 2017|
|Journal||Frontiers in Physiology|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Cox, E. F., Buchanan, C. E., Bradley, C. R., Prestwich, B., Mahmoud, H., Taal, M., …Francis, S. T. (2017). Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease. Frontiers in Physiology, 8, https://doi.org/10.3389/fphys.2017.00696|
|Keywords||magnetic resonance imaging, hemodynamics, oxygenation, renal function, arterial spin labeling|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Multiparametric MRI Validations interventions alterations CKD.pdf
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0