ELEANOR COX ELEANOR.COX@NOTTINGHAM.AC.UK
Senior Research Fellow
Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease
Cox, Eleanor F.; Buchanan, Charlotte E.; Bradley, Christopher R.; Prestwich, Benjamin; Mahmoud, Huda; Taal, Maarten; Selby, Nicholas M.; Francis, Susan T.
Authors
Dr CHARLOTTE BUCHANAN CHARLOTTE.BUCHANAN@NOTTINGHAM.AC.UK
Research Fellow
CHRISTOPHER BRADLEY CHRISTOPHER.BRADLEY@NOTTINGHAM.AC.UK
Mri Scanner Operator
Benjamin Prestwich
Huda Mahmoud
MAARTEN TAAL M.TAAL@NOTTINGHAM.AC.UK
Professor of Medicine
NICHOLAS SELBY Nicholas.Selby@nottingham.ac.uk
Professor of Nephrology
Professor SUSAN FRANCIS susan.francis@nottingham.ac.uk
Professor of Physics
Abstract
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping).
Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2*, diffusion (ADC, D, D*, fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1.5 T vs. 3 T) dependence of T1 and T2* relaxation times; (2) the repeatability of multiparametric MRI measures in 11 healthy participants; (3) changes in MRI measures in response to hypercapnic and hyperoxic modulations in six healthy participants; and (4) pilot data showing the application of the multiparametric protocol in 11 patients with Chronic Kidney Disease (CKD).
Results: Baseline measures were in-line with literature values, and as expected, T1-values were longer at 3 T compared with 1.5 T, with increased T1 corticomedullary differentiation at 3 T. Conversely, T2* was longer at 1.5 T. Inter-scan coefficients of variation (CoVs) of T1 mapping and ADC were very good at
Citation
Cox, E. F., Buchanan, C. E., Bradley, C. R., Prestwich, B., Mahmoud, H., Taal, M., …Francis, S. T. (2017). Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease. Frontiers in Physiology, 8, Article 696. https://doi.org/10.3389/fphys.2017.00696
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 30, 2017 |
Publication Date | Sep 14, 2017 |
Deposit Date | Sep 14, 2017 |
Publicly Available Date | Sep 14, 2017 |
Journal | Frontiers in Physiology |
Electronic ISSN | 1664-042X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Article Number | 696 |
DOI | https://doi.org/10.3389/fphys.2017.00696 |
Keywords | magnetic resonance imaging, hemodynamics, oxygenation, renal function, arterial spin labeling |
Public URL | https://nottingham-repository.worktribe.com/output/882915 |
Publisher URL | http://journal.frontiersin.org/article/10.3389/fphys.2017.00696/full |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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