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Outputs (31)

Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness (2024)
Journal Article
Hatziapostolou, M., Koutsioumpa, M., Zaitoun, A. M., Polytarchou, C., Edderkaoui, M., Mahurkar-Joshi, S., …Iliopoulos, D. (in press). Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness. Gastro Hep Advances, https://doi.org/10.1016/j.gastha.2024.04.005

Background and Aims Efforts to decode pancreatic ductal adenocarcinoma (PDAC) heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in PDAC progression. Met... Read More about Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness.

Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review (2024)
Journal Article
Kehlet, H., & Lobo, D. N. (2024). Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review. eClinicalMedicine, 70, Article 102510. https://doi.org/10.1016/j.eclinm.2024.102510

“Enhanced recovery after surgery” is a multimodal effort to control perioperative pathophysiology and improve outcome. However, despite advances in perioperative care, postoperative complications and the need for hospitalisation and prolonged recover... Read More about Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review.

The clinical significance of hypoalbuminaemia (2024)
Journal Article
Allison, S. P., & Lobo, D. N. (2024). The clinical significance of hypoalbuminaemia. Clinical Nutrition, 43(4), 909-914. https://doi.org/10.1016/j.clnu.2024.02.018

Albumin is a relatively small molecule with a radius of 7.5 nm and a molecular weight of 65 kDa. It is the most abundant protein in plasma, accounting for 60–75% of its oncotic pressure. Its concentration in plasma is merely one static measurement re... Read More about The clinical significance of hypoalbuminaemia.

A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms (2024)
Journal Article
Zareian, N., Eremin, O., Pandha, H., Baird, R., Kwatra, V., Funingana, G., …Spicer, J. (2024). A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms. Experimental Biology and Medicine, 249(1), https://doi.org/10.3389/ebm.2024.10021

The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) pepti... Read More about A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.

The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis (2024)
Journal Article
Skořepa, P., Ford, K. L., Alsuwaylihi, A., O’Connor, D., Prado, C. M., Gomez, D., & Lobo, D. N. (2024). The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis. Clinical Nutrition, 43(3), 629-648. https://doi.org/10.1016/j.clnu.2024.01.020

Background & aims: Prehabilitation comprises multidisciplinary preoperative interventions including exercise, nutritional optimisation and psychological preparation aimed at improving surgical outcomes. The aim of this systematic review and meta-anal... Read More about The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis.

Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations (2024)
Journal Article
Freys, J. C., Bigalke, S. M., Mertes, M., Lobo, D. N., Pogatzki-Zahn, E. M., Freys, S. M., & The PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA). (2024). Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations. European Journal of Anaesthesiology, 41(3), 174-187. https://doi.org/10.1097/eja.0000000000001953

BACKGROUND Despite being a commonly performed surgical procedure, pain management for appendicectomy is often neglected because of insufficient evidence on the most effective treatment options. OBJECTIVE To provide evidence-based recommendatio... Read More about Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations.

A recurrent retrohepatic abscess secondary to a dropped appendicolith (2024)
Journal Article
Sheikh, S., Kaur, M., Zaitoun, A. M., & Lobo, D. N. (2024). A recurrent retrohepatic abscess secondary to a dropped appendicolith. Radiology Case Reports, 19(3), 1176-1180. https://doi.org/10.1016/j.radcr.2023.12.040

Appendicoliths can drop into the peritoneal cavity during the course of an appendicectomy, or more commonly as a result of perforated appendicitis. We report the case of a patient with a history of recurrent retrohepatic abscesses over 7-year period... Read More about A recurrent retrohepatic abscess secondary to a dropped appendicolith.

Presentation and publication skills: How to review a paper (2023)
Journal Article
Deutz, N. E., Deutz, N. E., Delzenne, N., Davies, N. A., & Lobo, D. N. (2024). Presentation and publication skills: How to review a paper. Clinical Nutrition ESPEN, 59, 307-311. https://doi.org/10.1016/j.clnesp.2023.12.023

We provide comprehensive insights into the peer review process and guide potential reviewers through the steps of reviewing scientific manuscripts. We discuss essential aspects such as the reviewer’s responsibility in responding to invitations and ma... Read More about Presentation and publication skills: How to review a paper.

ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis (2023)
Journal Article
Arvanitakis, M., Ockenga, J., Bezmarevic, M., Gianotti, L., Krznarić, Ž., Lobo, D. N., …Bischoff, S. C. (2024). ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis. Clinical Nutrition, 43(2), 395-412. https://doi.org/10.1016/j.clnu.2023.12.019

Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in... Read More about ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis.

Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., Lobo, D. N., Arabia, S., & Greenfield, D. (2023). Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years. BJS Open, 7(6), Article zrad136. https://doi.org/10.1093/bjsopen/zrad136

Background While opioid analgesics are often necessary for the management of acute postoperative pain, appropriate prescribing practices are crucial to avoid harm. The aim was to investigate the changes in the proportion of people receiving initial... Read More about Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years.

Management standards and burnout among surgeons in the United Kingdom (2023)
Journal Article
Houdmont, J., Hassard, J., Daliya, P., Adiamah, A., Theophilidou, E., Lobo, D., & East Midlands Surgical Academic Network (EMSAN) Burnout Study Group, E. M. S. A. N. (. B. S. G. (2023). Management standards and burnout among surgeons in the United Kingdom. Occupational Medicine, Article kqad102. https://doi.org/10.1093/occmed/kqad102

Background Burnout arising from chronic work-related stress is endemic among surgeons in the UK. Identification of contributory and modifiable psychosocial work characteristics could inform risk reduction activities. Aims We aimed to assess th... Read More about Management standards and burnout among surgeons in the United Kingdom.

Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells (2023)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2023). Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells. Scientific Reports, 13(1), Article 16606. https://doi.org/10.1038/s41598-023-43946-6

Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. The aim of this study was to determine the effect of PIGR on cellular behaviours and chemo-sensiti... Read More about Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.

The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice (2023)
Journal Article
Lobo, D. N. (2023). The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice. Clinical Nutrition, 42(11), 2270-2281. https://doi.org/10.1016/j.clnu.2023.09.029

This review summarises some of my work on fluid and electrolyte balance over the past 25 years and shows how the studies have influenced clinical practice. Missing pieces in the jigsaw are filled in by summarising the work of others. The main theme i... Read More about The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice.

PROSPECT methodology for developing procedure-specific pain management recommendations: an update (2023)
Journal Article
Joshi, G. P., Albrecht, E., Van de Velde, M., Kehlet, H., Lobo, D. N., & PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy. (2023). PROSPECT methodology for developing procedure-specific pain management recommendations: an update. Anaesthesia, 78(11), 1386-1392. https://doi.org/10.1111/anae.16135

The procedure-specific postoperative pain management (PROSPECT) working group develops evidence-based pain management recommendations. PROSPECT methodology is unique and rigorous. However, several limitations were recognised that needed to be address... Read More about PROSPECT methodology for developing procedure-specific pain management recommendations: an update.

Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme (2023)
Journal Article
Jandu, A. K., Nitayamekin, A., Stevenson, J., Beed, M., Vohra, R. S., Wilson, V. G., & Lobo, D. N. (2023). Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme. World Journal of Surgery, 47(11), 2724-2732. https://doi.org/10.1007/s00268-023-07170-7

Background: Evidence suggests that physical fitness interventions, mental health support and nutritional advice before surgery (prehabilitation) could reduce hospital stay and improve quality of life of patients with cancer. In this study we captured... Read More about Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme.

Presentation and publication skills: How to get your paper published (2023)
Journal Article
Deutz, N. E., Delzenne, N., Grimble, G., & Lobo, D. N. (2023). Presentation and publication skills: How to get your paper published. Clinical Nutrition ESPEN, 57, 387-390. https://doi.org/10.1016/j.clnesp.2023.07.010

Getting your scientific paper published can be a difficult process. The quality of the paper relates to the quality of the design of the study, the questions asked, and defining an excellent primary endpoint that is easy to understand, and data obtai... Read More about Presentation and publication skills: How to get your paper published.

Presentation and publication skills: How to present a paper (2023)
Journal Article
Grimble, G., Lobo, D. N., Delzenne, N., & Deutz, N. E. (2023). Presentation and publication skills: How to present a paper. Clinical Nutrition ESPEN, 57, 410-413. https://doi.org/10.1016/j.clnesp.2023.07.009

Presenting a paper to a small or large audience should match both the knowledge level of your audience and the title and abstract you submitted to the conference. Your slides should give context to your work. Simpler slides and talks are easier to fo... Read More about Presentation and publication skills: How to present a paper.

Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial (2023)
Journal Article
Boesiger, F., Poggioli, A., Netzhammer, C., Bretscher, C., Kaegi-Braun, N., Tribolet, P., …Schuetz, P. (2023). Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial. European Journal of Clinical Nutrition, 77, 989–997. https://doi.org/10.1038/s41430-023-01303-w

Background: Serum albumin concentrations are frequently used to monitor nutritional therapy in the hospital setting but supporting studies are largely lacking. Within this secondary analysis of a randomized nutritional trial (EFFORT), we assessed whe... Read More about Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial.

Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis (2023)
Journal Article
Liu, S., Athar, A., Quach, D., Patanwala, A. E., Naylor, J. M., Stevens, J. A., …Penm, J. (2023). Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis. Anaesthesia, 78(10), 1225-1236. https://doi.org/10.1111/anae.16085

Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the availabl... Read More about Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis.

Presentation and publication skills: How to develop a protocol and write a grant (2023)
Journal Article
Delzenne, N., Deutz, N. E., Lobo, D. N., & Grimble, G. (2023). Presentation and publication skills: How to develop a protocol and write a grant. Clinical Nutrition ESPEN, 57, 73-76. https://doi.org/10.1016/j.clnesp.2023.06.009

In this education paper, we want to give some advice to aid in successful scientific grant writing. Besides defining an important research hypothesis and how to support this hypothesis, there are also technical aspects in grant writing that need to b... Read More about Presentation and publication skills: How to develop a protocol and write a grant.

Presentation and publication skills: Publication governance and pitfalls to avoid (2023)
Journal Article
Lobo, D. N., Grimble, G., Delzenne, N., & Deutz, N. E. (2023). Presentation and publication skills: Publication governance and pitfalls to avoid. Clinical Nutrition ESPEN, 57, 5-9. https://doi.org/10.1016/j.clnesp.2023.06.010

There are several pitfalls in the publication process that researchers can fall victim to, and these can occur knowingly or unknowingly. Although some of these errors may have occurred in good faith, disregard of publication governance is a dangerous... Read More about Presentation and publication skills: Publication governance and pitfalls to avoid.

Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care (2023)
Journal Article
Scott, M. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Balfour, A., Foss, N. B., …Peden, C. J. (2023). Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care. World Journal of Surgery, 47(8), 1850-1880. https://doi.org/10.1007/s00268-023-07020-6

Background This is Part 2 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy (EL) using an Enhanced Recovery After Surgery (ERAS) approach. This paper addresses intra- and postoperative aspects of care.... Read More about Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care.

Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient (2023)
Journal Article
Peden, C. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Balfour, A., Foss, N. B., …Scott, M. J. (2023). Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient. World Journal of Surgery, 47, 1881-1898. https://doi.org/10.1007/s00268-023-07039-9

Background: This is Part 3 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy using an enhanced recovery after surgery (ERAS) approach. This paper addresses organizational aspects of care. Methods: Experts... Read More about Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis (2023)
Journal Article
Koh, A., Oyende, O., Humes, D. J., & Lobo, D. N. (2023). Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis. Clinical Nutrition, 42(7), 1086-1094. https://doi.org/10.1016/j.clnu.2023.05.019

Background & aims: Chronic pancreatitis results in irreversible pancreatic dysfunction and malnutrition which, alongside excess alcohol intake, can increase the risk of low bone density. Osteoporosis increases the risk of fractures and chronic bone p... Read More about Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis (2023)
Journal Article
Rowley, A., Adiamah, A., Kushairi, A., Lewis, S. J., & Lobo, D. N. (2023). The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis. Clinical Nutrition, 42(7), 1189-1201. https://doi.org/10.1016/j.clnu.2023.04.028

Background Malnutrition is a risk-factor for adverse postoperative outcomes. This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on outcomes in patients undergoing gastrointestinal surge... Read More about The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis.