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The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study (2024)
Journal Article
Gysling, S., Lewis-Lloyd, C. A., Lobo, D. N., Crooks, C. J., & Humes, D. J. (in press). The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study. British Journal of Anaesthesia,

Background: Diabetes mellitus is a significant modulator of postoperative outcomes and is an important risk factor in the patient selection process. We aimed to investigate the effect of diabetes mellitus and use of insulin on outcomes following colo... Read More about The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study.

Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review (2024)
Journal Article
Kehlet, H., & Lobo, D. N. (2024). Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review. eClinicalMedicine, 70, Article 102510. https://doi.org/10.1016/j.eclinm.2024.102510

“Enhanced recovery after surgery” is a multimodal effort to control perioperative pathophysiology and improve outcome. However, despite advances in perioperative care, postoperative complications and the need for hospitalisation and prolonged recover... Read More about Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review.

The clinical significance of hypoalbuminaemia (2024)
Journal Article
Allison, S. P., & Lobo, D. N. (2024). The clinical significance of hypoalbuminaemia. Clinical Nutrition, 43(4), 909-914. https://doi.org/10.1016/j.clnu.2024.02.018

Albumin is a relatively small molecule with a radius of 7.5 nm and a molecular weight of 65 kDa. It is the most abundant protein in plasma, accounting for 60–75% of its oncotic pressure. Its concentration in plasma is merely one static measurement re... Read More about The clinical significance of hypoalbuminaemia.

A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms (2024)
Journal Article
Zareian, N., Eremin, O., Pandha, H., Baird, R., Kwatra, V., Funingana, G., …Spicer, J. (2024). A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms. Experimental Biology and Medicine, 249(1), https://doi.org/10.3389/ebm.2024.10021

The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) pepti... Read More about A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.

The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis (2024)
Journal Article
Skořepa, P., Ford, K. L., Alsuwaylihi, A., O’Connor, D., Prado, C. M., Gomez, D., & Lobo, D. N. (2024). The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis. Clinical Nutrition, 43(3), 629-648. https://doi.org/10.1016/j.clnu.2024.01.020

Background & aims: Prehabilitation comprises multidisciplinary preoperative interventions including exercise, nutritional optimisation and psychological preparation aimed at improving surgical outcomes. The aim of this systematic review and meta-anal... Read More about The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis.

Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations (2024)
Journal Article
Freys, J. C., Bigalke, S. M., Mertes, M., Lobo, D. N., Pogatzki-Zahn, E. M., Freys, S. M., & The PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA). (2024). Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations. European Journal of Anaesthesiology, 41(3), 174-187. https://doi.org/10.1097/eja.0000000000001953

BACKGROUND Despite being a commonly performed surgical procedure, pain management for appendicectomy is often neglected because of insufficient evidence on the most effective treatment options. OBJECTIVE To provide evidence-based recommendatio... Read More about Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations.

A recurrent retrohepatic abscess secondary to a dropped appendicolith (2024)
Journal Article
Sheikh, S., Kaur, M., Zaitoun, A. M., & Lobo, D. N. (2024). A recurrent retrohepatic abscess secondary to a dropped appendicolith. Radiology Case Reports, 19(3), 1176-1180. https://doi.org/10.1016/j.radcr.2023.12.040

Appendicoliths can drop into the peritoneal cavity during the course of an appendicectomy, or more commonly as a result of perforated appendicitis. We report the case of a patient with a history of recurrent retrohepatic abscesses over 7-year period... Read More about A recurrent retrohepatic abscess secondary to a dropped appendicolith.

Presentation and publication skills: How to review a paper (2023)
Journal Article
Deutz, N. E., Deutz, N. E., Delzenne, N., Davies, N. A., & Lobo, D. N. (2024). Presentation and publication skills: How to review a paper. Clinical Nutrition ESPEN, 59, 307-311. https://doi.org/10.1016/j.clnesp.2023.12.023

We provide comprehensive insights into the peer review process and guide potential reviewers through the steps of reviewing scientific manuscripts. We discuss essential aspects such as the reviewer’s responsibility in responding to invitations and ma... Read More about Presentation and publication skills: How to review a paper.

ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis (2023)
Journal Article
Arvanitakis, M., Ockenga, J., Bezmarevic, M., Gianotti, L., Krznarić, Ž., Lobo, D. N., …Bischoff, S. C. (2024). ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis. Clinical Nutrition, 43(2), 395-412. https://doi.org/10.1016/j.clnu.2023.12.019

Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in... Read More about ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis.

Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., Lobo, D. N., Arabia, S., & Greenfield, D. (2023). Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years. BJS Open, 7(6), Article zrad136. https://doi.org/10.1093/bjsopen/zrad136

Background While opioid analgesics are often necessary for the management of acute postoperative pain, appropriate prescribing practices are crucial to avoid harm. The aim was to investigate the changes in the proportion of people receiving initial... Read More about Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years.

Management standards and burnout among surgeons in the United Kingdom (2023)
Journal Article
Houdmont, J., Hassard, J., Daliya, P., Adiamah, A., Theophilidou, E., Lobo, D., & East Midlands Surgical Academic Network (EMSAN) Burnout Study Group, E. M. S. A. N. (. B. S. G. (2023). Management standards and burnout among surgeons in the United Kingdom. Occupational Medicine, Article kqad102. https://doi.org/10.1093/occmed/kqad102

Background Burnout arising from chronic work-related stress is endemic among surgeons in the UK. Identification of contributory and modifiable psychosocial work characteristics could inform risk reduction activities. Aims We aimed to assess th... Read More about Management standards and burnout among surgeons in the United Kingdom.

Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells (2023)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2023). Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells. Scientific Reports, 13(1), Article 16606. https://doi.org/10.1038/s41598-023-43946-6

Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. The aim of this study was to determine the effect of PIGR on cellular behaviours and chemo-sensiti... Read More about Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.

The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice (2023)
Journal Article
Lobo, D. N. (2023). The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice. Clinical Nutrition, 42(11), 2270-2281. https://doi.org/10.1016/j.clnu.2023.09.029

This review summarises some of my work on fluid and electrolyte balance over the past 25 years and shows how the studies have influenced clinical practice. Missing pieces in the jigsaw are filled in by summarising the work of others. The main theme i... Read More about The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice.

PROSPECT methodology for developing procedure-specific pain management recommendations: an update (2023)
Journal Article
Joshi, G. P., Albrecht, E., Van de Velde, M., Kehlet, H., Lobo, D. N., & PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy. (2023). PROSPECT methodology for developing procedure-specific pain management recommendations: an update. Anaesthesia, 78(11), 1386-1392. https://doi.org/10.1111/anae.16135

The procedure-specific postoperative pain management (PROSPECT) working group develops evidence-based pain management recommendations. PROSPECT methodology is unique and rigorous. However, several limitations were recognised that needed to be address... Read More about PROSPECT methodology for developing procedure-specific pain management recommendations: an update.

Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme (2023)
Journal Article
Jandu, A. K., Nitayamekin, A., Stevenson, J., Beed, M., Vohra, R. S., Wilson, V. G., & Lobo, D. N. (2023). Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme. World Journal of Surgery, 47(11), 2724-2732. https://doi.org/10.1007/s00268-023-07170-7

Background: Evidence suggests that physical fitness interventions, mental health support and nutritional advice before surgery (prehabilitation) could reduce hospital stay and improve quality of life of patients with cancer. In this study we captured... Read More about Post-Cancer Treatment Reflections by Patients Concerning the Provisions and Support Required for a Prehabilitation Programme.

Presentation and publication skills: How to present a paper (2023)
Journal Article
Grimble, G., Lobo, D. N., Delzenne, N., & Deutz, N. E. (2023). Presentation and publication skills: How to present a paper. Clinical Nutrition ESPEN, 57, 410-413. https://doi.org/10.1016/j.clnesp.2023.07.009

Presenting a paper to a small or large audience should match both the knowledge level of your audience and the title and abstract you submitted to the conference. Your slides should give context to your work. Simpler slides and talks are easier to fo... Read More about Presentation and publication skills: How to present a paper.

Presentation and publication skills: How to get your paper published (2023)
Journal Article
Deutz, N. E., Delzenne, N., Grimble, G., & Lobo, D. N. (2023). Presentation and publication skills: How to get your paper published. Clinical Nutrition ESPEN, 57, 387-390. https://doi.org/10.1016/j.clnesp.2023.07.010

Getting your scientific paper published can be a difficult process. The quality of the paper relates to the quality of the design of the study, the questions asked, and defining an excellent primary endpoint that is easy to understand, and data obtai... Read More about Presentation and publication skills: How to get your paper published.

Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial (2023)
Journal Article
Boesiger, F., Poggioli, A., Netzhammer, C., Bretscher, C., Kaegi-Braun, N., Tribolet, P., …Schuetz, P. (2023). Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial. European Journal of Clinical Nutrition, 77, 989–997. https://doi.org/10.1038/s41430-023-01303-w

Background: Serum albumin concentrations are frequently used to monitor nutritional therapy in the hospital setting but supporting studies are largely lacking. Within this secondary analysis of a randomized nutritional trial (EFFORT), we assessed whe... Read More about Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support. A secondary post-hoc analysis of a randomized clinical trial.

Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis (2023)
Journal Article
Liu, S., Athar, A., Quach, D., Patanwala, A. E., Naylor, J. M., Stevens, J. A., …Penm, J. (2023). Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis. Anaesthesia, 78(10), 1225-1236. https://doi.org/10.1111/anae.16085

Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the availabl... Read More about Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis.

Presentation and publication skills: How to develop a protocol and write a grant (2023)
Journal Article
Delzenne, N., Deutz, N. E., Lobo, D. N., & Grimble, G. (2023). Presentation and publication skills: How to develop a protocol and write a grant. Clinical Nutrition ESPEN, 57, 73-76. https://doi.org/10.1016/j.clnesp.2023.06.009

In this education paper, we want to give some advice to aid in successful scientific grant writing. Besides defining an important research hypothesis and how to support this hypothesis, there are also technical aspects in grant writing that need to b... Read More about Presentation and publication skills: How to develop a protocol and write a grant.

Presentation and publication skills: Publication governance and pitfalls to avoid (2023)
Journal Article
Lobo, D. N., Grimble, G., Delzenne, N., & Deutz, N. E. (2023). Presentation and publication skills: Publication governance and pitfalls to avoid. Clinical Nutrition ESPEN, 57, 5-9. https://doi.org/10.1016/j.clnesp.2023.06.010

There are several pitfalls in the publication process that researchers can fall victim to, and these can occur knowingly or unknowingly. Although some of these errors may have occurred in good faith, disregard of publication governance is a dangerous... Read More about Presentation and publication skills: Publication governance and pitfalls to avoid.

Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient (2023)
Journal Article
Peden, C. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Balfour, A., Foss, N. B., …Scott, M. J. (2023). Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient. World Journal of Surgery, 47, 1881-1898. https://doi.org/10.1007/s00268-023-07039-9

Background: This is Part 3 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy using an enhanced recovery after surgery (ERAS) approach. This paper addresses organizational aspects of care. Methods: Experts... Read More about Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient.

Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care (2023)
Journal Article
Scott, M. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Balfour, A., Foss, N. B., …Peden, C. J. (2023). Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care. World Journal of Surgery, 47(8), 1850-1880. https://doi.org/10.1007/s00268-023-07020-6

Background This is Part 2 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy (EL) using an Enhanced Recovery After Surgery (ERAS) approach. This paper addresses intra- and postoperative aspects of care.... Read More about Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis (2023)
Journal Article
Koh, A., Oyende, O., Humes, D. J., & Lobo, D. N. (2023). Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis. Clinical Nutrition, 42(7), 1086-1094. https://doi.org/10.1016/j.clnu.2023.05.019

Background & aims: Chronic pancreatitis results in irreversible pancreatic dysfunction and malnutrition which, alongside excess alcohol intake, can increase the risk of low bone density. Osteoporosis increases the risk of fractures and chronic bone p... Read More about Risk of osteopaenia, osteoporosis and osteoporotic fractures in patients with chronic pancreatitis: A systematic review and meta-analysis.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis (2023)
Journal Article
Rowley, A., Adiamah, A., Kushairi, A., Lewis, S. J., & Lobo, D. N. (2023). The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis. Clinical Nutrition, 42(7), 1189-1201. https://doi.org/10.1016/j.clnu.2023.04.028

Background Malnutrition is a risk-factor for adverse postoperative outcomes. This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on outcomes in patients undergoing gastrointestinal surge... Read More about The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis.

Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial (2023)
Journal Article
Bretscher, C., Buergin, M., Gurzeler, G., Kägi-Braun, N., Gressies, C., Tribolet, P., …for the EFFORT study team. (2023). Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial. Journal of Parenteral and Enteral Nutrition, 47(3), 408-419. https://doi.org/10.1002/jpen.2470

Background: Because of the shorter half-life as compared with albumin, serum prealbumin concentrations have been proposed to be useful nutrition biomarkers for the assessment of patients at nutrition risk. In a post hoc analysis of patients at nutrit... Read More about Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial.

Three Centuries of Appendicectomy (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2023). Three Centuries of Appendicectomy. World Journal of Surgery, 47, 928-936. https://doi.org/10.1007/s00268-022-06874-6

Background Save for the contribution of Charles McBurney, who described his eponymous point and the appendicectomy incision, the history of appendicectomy is largely unknown among the medical profession. This review traces the history from the first... Read More about Three Centuries of Appendicectomy.

Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient (2022)
Journal Article
Prado, C. M., Ford, K. L., Gonzalez, M. C., Murnane, L. C., Gillis, C., Wischmeyer, P. E., …Lobo, D. N. (2023). Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient. Journal of Parenteral and Enteral Nutrition, 47(S1), S54-S68. https://doi.org/10.1002/jpen.2420

Preoperative nutrition status is an important determinant of surgical outcomes, yet malnutrition assessment is not integrated into all surgical pathways. Given its importance and the high prevalence of malnutrition in patients undergoing surgical pro... Read More about Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.

Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients (2022)
Journal Article
Parsons, S. L., Daliya, P., Evans, P., & Lobo, D. N. (2023). Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients. World Journal of Surgery, 47, 649-657. https://doi.org/10.1007/s00268-022-06846-w

Background Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. It can be difficult to gauge patient understanding and address all... Read More about Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients.

Prehabilitation: high-quality evidence is still required (2022)
Journal Article
Lobo, D. N., Skořepa, P., Gomez, D., & Greenhaff, P. L. (2022). Prehabilitation: high-quality evidence is still required. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.09.016

Prehabilitation comprises multidisciplinary healthcare interventions, including exercise, nutritional optimisation, and psychological preparation, which aim to dampen the metabolic response to surgery, shorten the period of recovery, reduce complicat... Read More about Prehabilitation: high-quality evidence is still required.

Identification of Surgeon Burnout via a Single-Item Measure (2022)
Journal Article
Houdmont, J., Daliya, P., Adiamah, A., Theophilidou, E., Hassard, J., Lobo, D. N., …Young, L. (2022). Identification of Surgeon Burnout via a Single-Item Measure. Occupational Medicine, 72(9), 641-643. https://doi.org/10.1093/occmed/kqac116

Background Burnout is endemic in surgeons in the UK and linked with poor patient safety and quality of care, mental health problems, and workforce sustainability. Mechanisms are required to facilitate the efficient identification of burnout in this... Read More about Identification of Surgeon Burnout via a Single-Item Measure.

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2022). M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β. Scientific Reports, 12(1), Article 16842. https://doi.org/10.1038/s41598-022-20811-6

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., …Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2022). Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open, 6(4), Article zrac100

Background This aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis. Methods A search for randomized clinical trials compa... Read More about Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis.

Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Carvell, J., Rozentals, J., Lobo, D. N., & Parsons, S. L. (2022). Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, 46, 2648-2658. https://doi.org/10.1007/s00268-022-06684-w

Background: Although recommendations exist for patients to be offered a post-operative helpline or telephone follow-up appointment at discharge after cholecystectomy, implementation of these is resource-intensive. Whilst the benefits of telephone fol... Read More about Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study.

O038 Digital consent: modernising data-sharing in surgery and empowering patients (2022)
Journal Article
Daliya, P., Lobo, D., & Parsons, S. (2022). O038 Digital consent: modernising data-sharing in surgery and empowering patients. British Journal of Surgery, 109(Supplement_4), Article znac242.038. https://doi.org/10.1093/bjs/znac242.038

Introduction Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. Although many practitioners provide supplementary information to... Read More about O038 Digital consent: modernising data-sharing in surgery and empowering patients.

Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Lobo, D. N., & Parsons, S. L. (2022). Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, https://doi.org/10.1007/s00268-022-06588-9

Background The collection of patient-reported outcome measures (PROMs) has many benefits for clinical practice. However, there are many barriers that prevent them from becoming a part of routine clinical care. The aim of this feasibility study was t... Read More about Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study.

Unresolved issues in perioperative nutrition: A narrative review (2022)
Journal Article
Ford, K. L., Prado, C. M., Weimann, A., Schuetz, P., & Lobo, D. N. (2022). Unresolved issues in perioperative nutrition: A narrative review. Clinical Nutrition, 41(7), 1578-1590. https://doi.org/10.1016/j.clnu.2022.05.015

Surgical patients are at an increased risk of negative outcomes if they are malnourished or at risk of malnutrition preoperatively. Optimisation of nutritional status should be a focus throughout the perioperative continuum to promote improved surgic... Read More about Unresolved issues in perioperative nutrition: A narrative review.

Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial (2022)
Journal Article
Stalder, L., Kaegi-Braun, N., Gressies, C., Gregoriano, C., Tribolet, P., Lobo, D. N., …Schuetz, P. (2022). Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(6), 1307-1315. https://doi.org/10.1016/j.clnu.2022.04.025

Background & aims: Screening for malnutrition upon hospital admission is the first crucial step for proper nutritional assessment and treatment. While several nutritional screening and assessment instruments exist, there is a lack of head-to-head val... Read More about Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial.

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

Early Postoperative Supplementary Parenteral Nutrition (2022)
Journal Article
Ljungqvist, O., Gustafsson, U. O., & Lobo, D. N. (2022). Early Postoperative Supplementary Parenteral Nutrition. JAMA Surgery, 209, Article 118333. https://doi.org/10.1001/jamasurg.2022.0266

Molten salts have been used in solar thermal energy storage due to their high energy storage density, low cost and excellent chemical stability. However, their application is limited by “bad days” such as cloudy days and winter because the weak conce... Read More about Early Postoperative Supplementary Parenteral Nutrition.

System-level policies on appropriate opioid use, a multi-stakeholder consensus (2022)
Journal Article
Forget, P., Patullo, C., Hill, D., Ambekar, A., Baldacchino, A., Cata, J., …Gilbert, S. (2022). System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Services Research, 22(1), Article 329. https://doi.org/10.1186/s12913-022-07696-x

Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may he... Read More about System-level policies on appropriate opioid use, a multi-stakeholder consensus.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article
Althubeati, S., Avery, A., Tench, C., Lobo, D. N., Salter, A., & Eldeghaidy, S. (2022). Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis. Neuroscience and Biobehavioral Reviews, 136, Article 104603. https://doi.org/10.1016/j.neubiorev.2022.104603

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial (2022)
Journal Article
Kaegi-Braun, N., Boesiger, F., Tribolet, P., Gomes, F., Kutz, A., Hoess, C., …Schuetz, P. (2022). Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(4), 795-804. https://doi.org/10.1016/j.clnu.2022.02.009

Background & aims: The Global Leadership Initiative on Malnutrition (GLIM) recently suggested specific criteria to standardize the diagnosis of malnutrition. There is need for validation of these criteria regarding response to nutrition treatment. Ou... Read More about Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial.

Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial (2022)
Journal Article
Bretschera, C., Boesiger, F., Kaegi-Braun, N., Hersberger, L., Lobo, D. N., Evans, D. C., …Schuetz, P. (2022). Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial. EClinicalMedicine, 45, Article 101301. https://doi.org/10.1016/j.eclinm.2022.101301

Background Historically, admission serum albumin concentrations have been considered useful biochemical markers for nutrition assessment. However, there is a lack of randomised trial data investigating whether low albumin concentrations are helpful... Read More about Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids (2022)
Journal Article
Babaei-Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A., Kattan, S. W., Mansouri, O. A., …Nateri, A. S. (2022). Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 11, Article 4. https://doi.org/10.1038/s41389-021-00376-1

Little is known about the role of microRNAs (miRNAs) in rewiring the metabolism within tumours and adjacent non-tumour bearing normal tissue and their potential in cancer therapy. This study aimed to investigate the relationship between deregulated m... Read More about Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review (2021)
Journal Article
Macintyre, P. E., Quinlan, J., Levy, N., & Lobo, D. N. (2022). Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review. JAMA Surgery, 157(2), 158-166. https://doi.org/10.1001/jamasurg.2021.6210

Importance: Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis that started in North America and spread throughout high-income countries. The aim of this narrative review was to explore some of the current issues surro... Read More about Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review.

The importance of protein sources to support muscle anabolism in cancer: An expert group opinion (2021)
Journal Article
Ford, K. L., Arends, J., Atherton, P. J., Engelen, M. P., Gonçalves, T. J., Laviano, A., …Prado, C. M. (2022). The importance of protein sources to support muscle anabolism in cancer: An expert group opinion. Clinical Nutrition, 41(1), 192-201. https://doi.org/10.1016/j.clnu.2021.11.032

This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emp... Read More about The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study (2021)
Journal Article
Houdmont, J., Daliya, P., Theophilidou, E., Adiamah, A., Hassard, J., Lobo, D. N., & East Midlands Surgical Academic Network (EMSAN) Burnout Study Group. (2022). Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study. World Journal of Surgery, 46(1), 1-9. https://doi.org/10.1007/s00268-021-06351-6

Background: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic. Methods: This cross-sectional on... Read More about Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? (2021)
Journal Article
Ljungqvist, O., & Lobo, D. N. (2021). Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?. JAMA Surgery, 157(1), 41-42. https://doi.org/10.1001/jamasurg.2021.5273

Rosenberg and colleagues1 first proposed the use of nonabsorbable oral antibiotic preparation (OAB) for colorectal surgery in 1971. In a randomized clinical trial, they demonstrated a reduction in surgical site infection and anastomotic leak rates af... Read More about Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?.

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis (2021)
Journal Article
Anis, F. S., Adiamah, A., Lobo, D. N., & Sanyal, S. (2022). Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis. Journal of Gastroenterology and Hepatology, 37(3), 446-454. https://doi.org/10.1111/jgh.15711

Background and Aim: This meta-analysis aimed to estimate the incidence of splanchnic vein thrombosis (SVT) in patients with acute pancreatitis and assess the effects of therapeutic anticoagulation. Methods: Systematic searches of the Medline, Embase,... Read More about Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis.

Management of disease-related malnutrition for patients being treated in hospital (2021)
Journal Article
Schuetz, P., Seres, D., Lobo, D. N., Gomes, F., Kaegi-Braun, N., & Stanga, Z. (2021). Management of disease-related malnutrition for patients being treated in hospital. Lancet, 398(10314), 1927-1938. https://doi.org/10.1016/S0140-6736%2821%2901451-3

Disease-related malnutrition in adult patients who have been admitted to hospital is a syndrome associated with substantially increased morbidity, disability, short-term and long-term mortality, impaired recovery from illness, and cost of care. There... Read More about Management of disease-related malnutrition for patients being treated in hospital.

Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer (2021)
Journal Article
Adiamah, A., Rollins, K. E., Kapeleris, A., Welch, N. T., Iftikhar, S. Y., Allison, S. P., & Lobo, D. N. (2021). Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer. Clinical Nutrition, 40(11), 5482-5485. https://doi.org/10.1016/j.clnu.2021.09.040

Background & aims: Immune modulating nutrition (IMN) has been shown to reduce postoperative infectious complications and length of stay in patients with gastrointestinal cancer. Two studies of IMN in patients undergoing surgery for head and neck canc... Read More about Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer.

Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain (2021)
Journal Article
Psaltis, E., Zaitoun, A. M., Neal, K. R., & Lobo, D. N. (2021). Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain. World Journal of Surgery, 45(12), 3592-3602. https://doi.org/10.1007/s00268-021-06288-w

Background Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices re... Read More about Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Perioperative Opioids - Reclaiming Lost Ground (2021)
Journal Article
Fawcett, W. J., Ljungqvist, O., & Lobo, D. N. (2021). Perioperative Opioids - Reclaiming Lost Ground. JAMA Surgery, 156(11), 997-998. https://doi.org/10.1001/jamasurg.2021.2858

Opium (poppy tears) has been in use since 3400 BCE, with historical writings recording its sedative, euphoric, and analgesic properties, but it was not until the 19th century that morphine was isolated, paving the way for its therapeutic use. The 20t... Read More about Perioperative Opioids - Reclaiming Lost Ground.

Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review (2021)
Journal Article
Ljungqvist, O., de Boer, H. D., Balfour, A., Fawcett, W. J., Lobo, D. N., Nelson, G., …Demartines, N. (2021). Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review. JAMA Surgery, 156(8), 775-784. https://doi.org/10.1001/jamasurg.2021.0586

Importance: Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative now firmly entrenched within the field of perioperative care. Although ERAS is associated with significant clinical outcome improvements and cost... Read More about Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review.

ESPEN practical guideline: Clinical nutrition in surgery (2021)
Journal Article
Weimann, A., Braga, M., Carli, F., Higashiguchi, T., Hübner, M., Klek, S., …Singer, P. (2021). ESPEN practical guideline: Clinical nutrition in surgery. Clinical Nutrition, 40(7), 4745-4761. https://doi.org/10.1016/j.clnu.2021.03.031

Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. Considering that malnutrition and underfeeding are r... Read More about ESPEN practical guideline: Clinical nutrition in surgery.

Opioid prescription at postoperative discharge: a retrospective observational cohort study (2021)
Journal Article
Daliya, P., Adiamah, A., Roslan, F., Theophilidou, E., Knaggs, R., Levy, N., & Lobo, D. (2021). Opioid prescription at postoperative discharge: a retrospective observational cohort study. Anaesthesia, 76(10), 1367-1376. https://doi.org/10.1111/anae.15460

Opioid misuse is now considered a major public health epidemic in North America, with substantial social and financial consequences. As well as socio-economic and commercial drivers, modifiable risk-factors that have resulted in this crisis have been... Read More about Opioid prescription at postoperative discharge: a retrospective observational cohort study.

Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization (2021)
Journal Article
Peden, C. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Bang Foss, N., Cooper, Z., …Scott, M. (2021). Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization. World Journal of Surgery, 45, 1272–1290. https://doi.org/10.1007/s00268-021-05994-9

Background Enhanced Recovery After Surgery (ERAS) protocols reduce length of stay, complications and costs fora large number of elective surgical procedures. A similar, structured approach appears to improve outcomes, including mortality, for patien... Read More about Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization.

Patient-centric goal-oriented perioperative care (2021)
Journal Article
Roberts, G. P., Levy, N., & Lobo, D. N. (2021). Patient-centric goal-oriented perioperative care. British Journal of Anaesthesia, 126(3), 559-564. https://doi.org/10.1016/j.bja.2020.12.004

Anaesthetists and surgeons largely focus on quantifiable postoperative outcome measures as a means for improving the quality of patient care. However, whilst traditional measures, such as postoperative morbidity and mortality, are useful and relative... Read More about Patient-centric goal-oriented perioperative care.

The centenary of the Harris–Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group (2020)
Journal Article
Bendavid, I., Lobo, D. N., Barazzoni, R., Cederholm, T., Coëffier, M., Schueren, M. D. V. D., …Singer, P. (2021). The centenary of the Harris–Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group. Clinical Nutrition, 40(3), 690-701. https://doi.org/10.1016/j.clnu.2020.11.012

Background & aims: The year 2019 marked the centenary of the publication of the Harris and Benedict equations for estimation of energy expenditure. In October 2019 a Scientific Symposium was organized by the European Society for Clinical Nutrition an... Read More about The centenary of the Harris–Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group.

Enhanced recovery after surgery: Current status and future progress (2020)
Journal Article
Rollins, K. E., Lobo, D. N., & Joshi, G. P. (2021). Enhanced recovery after surgery: Current status and future progress. Best Practice and Research: Clinical Anaesthesiology, 35(4), 479-489. https://doi.org/10.1016/j.bpa.2020.10.001

Enhanced Recovery After Surgery (ERAS) pathways were first introduced almost a quarter of a century ago and represent a paradigm shift in perioperative care that reduced postoperative complications and hospital length of stay, improved postoperative... Read More about Enhanced recovery after surgery: Current status and future progress.

An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients (2020)
Journal Article
Levy, N., Quinlan, J., El‐Boghdadly, K., Fawcett, W. J., Agarwal, V., Bastable, R. B., …Macintyre, P. E. (2020). An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients. Anaesthesia, 76(4), 520-536. https://doi.org/10.1111/anae.15262

This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri‐operative use of opioids in adults. An international panel of healthcare professionals evaluated the literature relating to postopera... Read More about An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients.

Turning ‘waiting lists’ for elective surgery into ‘preparation lists’ (2020)
Journal Article
Levy, N., Selwyn, D., & Lobo, D. (2021). Turning ‘waiting lists’ for elective surgery into ‘preparation lists’. British Journal of Anaesthesia, 126(1), 1-5. https://doi.org/10.1016/j.bja.2020.08.021

Waiting lists for surgery are an integral part of the UK National Health Service (NHS); they are used as a construct to ration surgery and to reduce costs, whilst simultaneously attempting to distribute limited health resources in an equitable manner... Read More about Turning ‘waiting lists’ for elective surgery into ‘preparation lists’.

Fasting and surgery timing (FaST) audit (2020)
Journal Article
El-Sharkawy, A. M., Daliya, P., Lewis-Lloyd, C., Adiamah, A., Malcolm, F. L., Boyd-Carson, H., …Wolff, J. (2021). Fasting and surgery timing (FaST) audit. Clinical Nutrition, 40(3), 1405-1412. https://doi.org/10.1016/j.clnu.2020.08.033

Background & aims International guidance advocates the avoidance of prolonged preoperative fasting due to its negative impact on perioperative hydration. This study aimed to assess the adherence to these guidelines for fasting in patients undergoi... Read More about Fasting and surgery timing (FaST) audit.

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function (2020)
Journal Article
Atkins, R., Constantin-Teodosiu, D., Varadhan, K. K., Constantin, D., Lobo, D. N., & Greenhaff, P. L. (2021). Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function. Clinical Nutrition, 40(3), 1046-1051. https://doi.org/10.1016/j.clnu.2020.07.006

© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rates... Read More about Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function.

Hypertriglyceridaemia as a risk factor for critical care admission in acute pancreatitis: A prospective study (2020)
Journal Article
Adiamah, A., Kushairi, A., Tumulty, S., Na, Y., Crook, M., Brooks, A. J., …Nottingham University Hospitals Hepatopancreaticobiliary Team. (2020). Hypertriglyceridaemia as a risk factor for critical care admission in acute pancreatitis: A prospective study. Clinical Nutrition ESPEN, 39, 227-233. https://doi.org/10.1016/j.clnesp.2020.06.008

Background and aims Hypertriglyceridaemia is both a primary cause of acute pancreatitis and an epiphenomenon. This study aimed to define the associations between hypertriglyceridaemia and clinical outcomes in patients admitted with acute pancreatiti... Read More about Hypertriglyceridaemia as a risk factor for critical care admission in acute pancreatitis: A prospective study.

Perioperative nutrition: Recommendations from the ESPEN expert group (2020)
Journal Article
Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N., Dhatariya, K., …Weimann, A. (2020). Perioperative nutrition: Recommendations from the ESPEN expert group. Clinical Nutrition, 39(11), 3211-3227. https://doi.org/10.1016/j.clnu.2020.03.038

© 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in N... Read More about Perioperative nutrition: Recommendations from the ESPEN expert group.

The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials (2020)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Scott, M. J., & Lobo, D. N. (2020). The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials. European Journal of Anaesthesiology, 37(8), 659-670. https://doi.org/10.1097/eja.0000000000001165

BACKGROUND There has recently been increasing interest in the use of peri-operative intravenous lidocaine (IVL) due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefits are not well established in electi... Read More about The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials.

ESPEN guideline on clinical nutrition in acute and chronic pancreatitis (2020)
Journal Article
Arvanitakis, M., Ockenga, J., Bezmarevic, M., Gianotti, L., Krznarić, Ž., Lobo, D. N., …Bischoff, S. (2020). ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clinical Nutrition, 39(3), 612-631. https://doi.org/10.1016/j.clnu.2020.01.004

Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in... Read More about ESPEN guideline on clinical nutrition in acute and chronic pancreatitis.

Restoration of function: the holy grail of peri?operative care (2020)
Journal Article
Levy, N., Grocott, M., & Lobo, D. (2020). Restoration of function: the holy grail of peri?operative care. Anaesthesia, 75(S1), e14-e17. https://doi.org/10.1111/anae.14893

In this collaborative supplement published byAnaesthesiaand theBritish Journal of Surgery, there are reviews ofenhanced recovery after surgery in both the elective [1] andthe emergency patient [2] by Kehlet, a surgeon fromDenmark. These are complimen... Read More about Restoration of function: the holy grail of peri?operative care.

Response to the Comment on “Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials” (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., & Lobo, D. (2021). Response to the Comment on “Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials”. Annals of Surgery, 274(6), e676-e677. https://doi.org/10.1097/SLA.0000000000003759

Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines (2019)
Journal Article
Brindle, M., Nelson, G., Lobo, D. N., Ljungqvist, O., & Gustafsson, U. O. (2020). Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines. BJS Open, 4(1), 157-163. https://doi.org/10.1002/bjs5.50238

Background ERAS® Society guidelines are holistic, multidisciplinary tools designed to improve outcomes after surgery. The enhanced recovery after surgery (ERAS) approach was initially developed for colorectal surgery and has been implemented success... Read More about Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines.

Response to Comment on "Knight SR, et al.: The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer" (2019)
Journal Article
Adiamah, A., Sko?epa, P., Weimann, A., & Lobo, D. N. (2019). Response to Comment on "Knight SR, et al.: The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer". Annals of Surgery, 270(6), e128-e129. https://doi.org/10.1097/SLA.0000000000003340

Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults (2019)
Journal Article
El-Sharkawy, A. M., Devonald, M. A. J., Humes, D. J., Sahota, O., & Lobo, D. N. (2020). Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults. Clinical Nutrition, 39(8), P2593-2599. https://doi.org/10.1016/j.clnu.2019.11.030

© 2019 The Author(s) Background & aims: Hospitalised older adults are vulnerable to dehydration. However, the prevalence of hyperosmolar dehydration (HD) and its impact on outcome is unknown. Serum osmolality is not measured routinely but osmolarity,... Read More about Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults.

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals (2019)
Journal Article
Chowdhury, A. H., Cámara, M., Verma, C., Eremin, O., Kulkarni, A. D., & Lobo, D. N. (2019). Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals. Nutrients, 11(10), Article 2470. https://doi.org/10.3390/nu11102470

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Jap... Read More about Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals.

Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values (2019)
Journal Article
Rollins, K. E., Gopinath, A., Awwad, A., Macdonald, I. A., & Lobo, D. N. (2020). Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values. Clinical Nutrition, 39(7), 2227-2232. https://doi.org/10.1016/j.clnu.2019.10.003

Background and aims Computed tomography (CT)-based measurement of skeletal muscle cross-sectional area (CSA) and Hounsfield unit (HU) radiodensity are used to assess the presence of sarcopenia and myosteatosis, respectively. The validated CT-based t... Read More about Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values.

Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study (2019)
Journal Article
Mytton, J., Daliya, P., Singh, P., Parsons, S., Lobo, D., Lilford, R., & Vohra, R. (2021). Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study. Annals of Surgery, 274(2), 367-374. https://doi.org/10.1097/SLA.0000000000003599

Objective: The objective of this study was to evaluate the differences between patients who undergo cholecystectomy following index admission for cholecystitis, and those who are managed nonoperatively. Summary Background Data: Index emergency... Read More about Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study.

IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma (2019)
Conference Proceeding
Budd, W., Mukherjee, A., Lobo, D., & Zaitoun, A. (2019). IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma. In Supplement: Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 2–4 July 2019 (S1-S59). https://doi.org/10.1002/path.5345

Purpose of the study: IgG4, a member of the immunoglobulin family, has been implicated in the pathobiology of inflammatory disease (including autoimmune pancreatitis) and cancers. Its role in pancreatic cancers however remains to be elucidated. This... Read More about IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma.

Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P., Adimah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A., Sarmah, P., …Lobo, D. (2019). Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9, Article e028753. https://doi.org/10.1136/bmjopen-2018-028753

Objectives: To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design: This questionnaire study was designed with the help of patient groups. Dat... Read More about Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact.

Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P. J. J., Adiamah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A. M., Sarmah, P. B., …Lobo, D. N. (2019). Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9(9), 1-8. https://doi.org/10.1136/bmjopen-2018-028753

Objectives To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design This questionnaire study was designed with the help of patient groups. Data... Read More about Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact.

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. N. (2020). Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 271(6), 1036-1047. https://doi.org/10.1097/sla.0000000000003581

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More about Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla (2019)
Working Paper
Al-hadyan, K., Storr, S., Zaitoun, A., Lobo, D., & Martin, S. Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla

Background: Pancreatic cancer (PC), including the ampulla and bile duct, is very aggressive, and thus difficult to treat with effective therapies. The current treatment options have failed to improve PC five-year survival rates over the last 30 to 40... Read More about Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla.

Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery (2019)
Journal Article
Rollins, K., Mathias, N., & Lobo, D. (2019). Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery. BJS Open, 3(5), 606-616. https://doi.org/10.1002/bjs5.50188

Background: Intraoperative goal-directed fluid therapy (GDFT) is recommended for intraoperative fluid management for elective colorectal surgery in most perioperative guidelines. However, the evidence in elective colorectal surgery alone is not welle... Read More about Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery.

A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, 8(3), 228-245. https://doi.org/10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More about A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy.

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, 22(6), e215–e216. https://doi.org/10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More about Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28.

The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis. Annals of Surgery, 270(2), 247-246. https://doi.org/10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More about The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2020). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, 39(1), 304-305. https://doi.org/10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More about The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig (2019)
Journal Article
Hammond, J. S., Godtliebsen, F., Steigen, S., Guha, I. N., Wyatt, J., Revhaug, A., …Mortensen, K. E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science, 133(1), 153-166. https://doi.org/10.1042/CS20180858

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis and when PVP is reduced, rates of liver dysfunction decrease. The aim of this s... Read More about The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig.

The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Acheson, A. G., & Lobo, D. N. (2019). The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis. Annals of Surgery, 270(1), 43-58. https://doi.org/10.1097/SLA.0000000000003145

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. Objectives:To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery.Summary Background Data:... Read More about The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis.

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (2018)
Journal Article
Gustafsson, U. O., Scott, M. J., Hubner, M., Nygren, J., Demartines, N., Francis, N., …Ljungqvist, O. (2019). Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018. World Journal of Surgery, 43(3), 659-695. https://doi.org/10.1007/s00268-018-4844-y

Background: This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® prot... Read More about Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018.

Intestinal failure in adults: recommendations from the ESPEN Expert Groups (2018)
Journal Article
Pironi, L., Corcos, O., Forbes, A., Holst, M., Joly, F., Jonkers, C., …ESPEN Acute and Chronic Intestinal Failure Special Interest Groups. (2018). Intestinal failure in adults: recommendations from the ESPEN Expert Groups. Clinical Nutrition, 36(6A), 1798-1809. https://doi.org/10.1016/j.clnu.2018.07.036

Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain h... Read More about Intestinal failure in adults: recommendations from the ESPEN Expert Groups.

The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies (2018)
Journal Article
Elias, K. M., Stone, A. B., McGinigle, K., Tankou, J. I., Scott, M. J., Fawcett, W. J., …the ERAS® Society and ERAS® USA. (2019). The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies. World Journal of Surgery, 43(1), 1-8. https://doi.org/10.1007/s00268-018-4753-0

Background: Enhanced Recovery After Surgery (ERAS) programs are multimodal care pathways designed to minimize the physiologic and psychological impact of surgery for patients. Increased compliance with ERAS guidelines is associated with improved pati... Read More about The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article
Rollins, K. E., Awwad, A., MacDonald, I. A., & Lobo, D. N. (2019). A comparison of two different software packages for the analysis of body composition using computed tomography images. Nutrition, 57, 92-96. https://doi.org/10.1016/j.nut.2018.06.003

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.

Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study (2018)
Journal Article
Tewari, N., Awad, S., Duška, F., Williams, J. P., Bennett, A., MacDonald, I. A., & Lobo, D. N. (2018). Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study. Clinical Nutrition, https://doi.org/10.1016/j.clnu.2018.01.032

Background and Aims: The aims of this study were to identify whether differences in distribution of adipose tissue and skeletal muscle in obese and non-obese individuals contribute to the magnitude of the postoperative inflammatory response and insul... Read More about Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study.

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer (2018)
Journal Article
Ghaneh, P., Hanson, R., Titman, A., Lancaster, G., Plumpton, C., Lloyd-Williams, H., …Neoptolemos, J. P. (2018). PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. Health Technology Assessment, 22(7), 1-114. https://doi.org/10.3310/hta22070

Background: Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value t... Read More about PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.

Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., & Lobo, D. N. (in press). Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis. World Journal of Gastroenterology, 24(4), https://doi.org/10.3748/wjg.v24.i4.519

AIM: To analyse the effect of mechanical bowel preparation vs no mechanical bowel preparation on outcome in patients undergoing elective colorectal surgery. METHODS: Meta-analysis of randomised controlled trials and observational studies comparing a... Read More about Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis.

Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study (2018)
Journal Article
Francis, N. K., Walker, T., Carter, F., Hübner, M., Balfour, A., Jakobsen, D. H., …Ljungqvist, O. (2018). Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study. World Journal of Surgery, 42(7), 1919–1928. https://doi.org/10.1007/s00268-017-4436-2

Background Enhanced Recovery After Surgery (ERAS) is widely accepted in current surgical practice due to its positive impact on patient outcomes. The successful implementation of ERAS is chal-lenging and compliance with protocols varies widely. Cont... Read More about Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study.

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery (2017)
Journal Article
Varadhan, K. K., Constantin-Teodosiu, D., Constantin, D., Greenhaff, P. L., & Lobo, D. N. (2017). Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery. Clinical Nutrition, 37(6, Part A), 2178-2185. https://doi.org/10.1016/j.clnu.2017.10.020

Background & aims: Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether incr... Read More about Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article
Bragg, D. D., Edis, H., Clark, S., Parsons, S. L., Perumpalath, B., Lobo, D. N., & Maxwell-Armstrong, C. A. (in press). Development of a telehealth monitoring service after colorectal surgery: a feasibility study. World Journal of Gastroenterology, 9(9), https://doi.org/10.4240/wjgs.v9.i9.193

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol. METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.

Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies (2017)
Journal Article
Mitchell, W. K., Thomas, P. F., Zaitoun, A. M., Brooks, A. J., & Lobo, D. N. (in press). Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies. World Journal of Gastroenterology, 23(23), https://doi.org/10.3748/wjg.v23.i23.4252

AIM To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of follow-up. METHODS Neoplastic lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Les... Read More about Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies.

Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites (2017)
Journal Article
Hariharan, D., Wilkes, E. A., Aithal, G. P., Travis, S., & Lobo, D. N. (2017). Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites. Annals of The Royal College of Surgeons of England, 99(5), Article e145-e147. https://doi.org/10.1308/rcsann.2017.0058

A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of inser... Read More about Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites.

Spontaneous extrusion of gallstones after percutaneous drainage (2017)
Journal Article
Hariharan, D., & Lobo, D. N. (2017). Spontaneous extrusion of gallstones after percutaneous drainage. Annals of The Royal College of Surgeons of England, 99(3), Article e1-e2. https://doi.org/10.1308/rcsann.2017.0015

There have been reports of late discharge of gallstones through operative wounds after spillage into the peritoneal cavity during laparoscopic cholecystectomy and after the development of spontaneous cholecystocutaneous fistulae. However, spontaneous... Read More about Spontaneous extrusion of gallstones after percutaneous drainage.

The Impact of Sarcopenia and Myosteatosis on Outcomes of Unresectable Pancreatic Cancer or Distal 1 Cholangiocarcinoma (2016)
Journal Article
Rollins, K. E., Tewari, N., Ackner, A., Awwad, A., Madhusudan, S., Macdonald, I. A., …Lobo, D. N. (2016). The Impact of Sarcopenia and Myosteatosis on Outcomes of Unresectable Pancreatic Cancer or Distal 1 Cholangiocarcinoma. Clinical Nutrition, 35(5), 1103-1109. https://doi.org/10.1016/j.clnu.2015.08.005

Abstract Background and aims: Patients with pancreatic cancer have a poor prognosis, are often cachectic, and frequently demonstrate features of systemic inflammation, which may contribute to the phenomenon of myosteatosis. Analysis of body compos... Read More about The Impact of Sarcopenia and Myosteatosis on Outcomes of Unresectable Pancreatic Cancer or Distal 1 Cholangiocarcinoma.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
Chowdhury, A. H., Camara, M., Martinez-Pomares, L., Zaitoun, A. M., Eremin, O., Aithal, G. P., & Lobo, D. (2016). Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography. Clinical Science, 130(17), 1535-1544. https://doi.org/10.1042/CS20160326

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

Major abdominal surgery in Jehovah’s Witnesses (2016)
Journal Article
Rollins, K. E., Contractor, U., Inumerable, R., & Lobo, D. N. (2016). Major abdominal surgery in Jehovah’s Witnesses. Annals of The Royal College of Surgeons of England, 98(8), https://doi.org/10.1308/rcsann.2016.0210

Introduction Patients who are Jehovah’s Witnesses pose difficult ethical and moral dilemmas for surgeons because of their refusal to receive blood and blood products. This article outlines the personal experiences of six Jehovah’s Witnesses who un... Read More about Major abdominal surgery in Jehovah’s Witnesses.

Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway (2016)
Journal Article
Mo, D., Fang, H., Niu, K., Liu, J., Wu, M., Li, S., …Zhao, Y. (2016). Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway. Cancer Research, 76(10), https://doi.org/10.1158/0008-5472.CAN-15-2361

Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic an... Read More about Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.

A dangerous loop (2016)
Journal Article
Ahmad, S., Bragg, D., Zaitoun, A., & Lobo, D. N. (in press). A dangerous loop. Clinical Case Reports, 4(5), https://doi.org/10.1002/ccr3.563

Key Clinical Message: A 76-year-old man developed a hemoperitoneum after ERCP for choledocholithiasis. He underwent a laparotomy and splenectomy for a capsular tear at the splenic hilum, a rare complication of ERCP. “Bowing” of the endoscope with to... Read More about A dangerous loop.

3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors (2016)
Journal Article
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., …Grabowska, A. M. (2016). 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors. Molecular Cancer Therapeutics, 15(4), https://doi.org/10.1158/1535-7163.MCT-15-0598

There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular... Read More about 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors.

Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials (2016)
Journal Article
Rollins, K. E., & Lobo, D. N. (2016). Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 263(3), 465-476. https://doi.org/10.1097/sla.0000000000001366

Objectives: To compare the effects of intraoperative goal-directed fluid therapy (GDFT) with conventional fluid therapy, and determine whether there was a difference in outcome between studies that did and did not use Enhanced Recovery After Surg... Read More about Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials.

Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study (2016)
Journal Article
Chowdhury, A. H., Murray, K., Hoad, C. L., Costigan, C., Marciani, L., MacDonald, I. A., …Lobo, D. N. (2016). Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study. Annals of Surgery, 263(3), 450-457. https://doi.org/10.1097/SLA.0000000000001110

Objective: We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on gastric emptying, small bowel water content, and splanchnic blood flow measured by magnetic resonance imaging (MRI) in the context of changes in plasma gast... Read More about Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study.

Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome (2015)
Journal Article
Shaw, A. D., Schermer, C. R., Lobo, D. N., Munson, S. H., Khangulov, V., Hayashida, D. K., & Kellum, J. A. (2015). Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Critical Care, 19, Article 334. https://doi.org/10.1186/s13054-015-1045-z

Introduction: Intravenous (IV) fluids may be associated with complications not often attributed to fluid type. Fluids with high chloride concentrations such as 0.9 % saline have been associated with adverse outcomes in surgery and critical care. Unde... Read More about Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome.

Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression (2014)
Journal Article
Fosse Gjessing, P., Constantin-Teodosiu, D., Hagve, M., Lobo, D. N., Revhaug, A., & Irtun, Ø. (2015). Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression. Clinical Nutrition, 34(6), 1177-1183. https://doi.org/10.1016/j.clnu.2014.12.004

Functional recovery is considered the most important target: a survey of dedicated professionals (2014)
Journal Article
Aahlin, E. K., von Meyenfeldt, M., Dejong, C. H., Ljungqvist, O., Fearon, K. C., Lobo, D. N., …Lassen, K. (2014). Functional recovery is considered the most important target: a survey of dedicated professionals. Perioperative Medicine, 3(1), https://doi.org/10.1186/2047-0525-3-5

Background: The aim of this study was to survey the relative importance of postoperative recovery targets and perioperative care items, as perceived by a large group of international dedicated professionals. Methods: A questionnaire with eight posto... Read More about Functional recovery is considered the most important target: a survey of dedicated professionals.

Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (2014)
Journal Article
Lobo, D., MacDonald, N., Pearse, R. M., Parnell, W., Harrison, D. A., Niebrzegowska, E., …Treasure, T. (2014). Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review. Journal of the American Medical Association, 311(21), 2180-2190. https://doi.org/10.1001/jama.2014.5305

A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers (2014)
Journal Article
Chowdhury, A., Fox, E., Francis, S., & Lobo, D. (2014). A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers. Annals of Surgery, 259(5), 881–887. https://doi.org/10.1097/SLA.0000000000000324

Objective: We compared the effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Voluven; Fresenius Kabi, Runcorn, United Kingdom) and a “balanced” preparation of 6% hydroxyethyl starch (potato-derived) [Plas... Read More about A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers.

The pathophysiology of fluid and electrolyte balance in the older adult surgical patient (2013)
Journal Article
El-Sharkawy, A. M., Sahota, O., Maughan, R. J., & Lobo, D. N. (2013). The pathophysiology of fluid and electrolyte balance in the older adult surgical patient. Clinical Nutrition, 33(1), https://doi.org/10.1016/j.clnu.2013.11.010

Background & aims: Age-related physiological changes predispose even the healthy older adult to fluid and electrolyte abnormalities which can cause morbidity and mortality. The aim of this narrative review is to highlight key aspects of age-relat... Read More about The pathophysiology of fluid and electrolyte balance in the older adult surgical patient.

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays (2013)
Journal Article
Tewari, N., Zaitoun, A. M., Arora, A., Madhusudan, S., Ilyas, M., & Lobo, D. N. (2013). The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays. BMC Cancer, 13, Article 436. https://doi.org/10.1186/1471-2407-13-436

Background Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma.... Read More about The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays.

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? (2013)
Journal Article
Abdel-Fatah, T., Arora, A., Gorguc, I., Abbotts, R., Beebeejaun, S., Storr, S. J., …Madhusudan, S. (2013). Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?. Antioxidants and Redox Signaling, 18(18), https://doi.org/10.1089/ars.2012.4873

Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA rep... Read More about Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?.

Intestinal ischemia following laparoscopic surgery: a case series (2013)
Journal Article
Al-Khyatt, W., Thomas, J. D., Humes, D. J., & Lobo, D. N. (2013). Intestinal ischemia following laparoscopic surgery: a case series. Journal of Medical Case Reports, 7(25), Article 25. https://doi.org/10.1186/1752-1947-7-25

Introduction: Intestinal ischemia is a rare complication of laparoscopic surgery. Its prognosis depends on a high index of suspicion and effective early treatment. Case presentation: In the present report, we describe three cases where intestinal i... Read More about Intestinal ischemia following laparoscopic surgery: a case series.

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy (2012)
Journal Article
Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), https://doi.org/10.3748/wjg.v18.i16.1915

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response. METHODS: Formalin-fixed human gastro-oesophageal cancers were... Read More about Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy.

Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials (2012)
Journal Article
Varadhan, K. K., Neal, K. R., & Lobo, D. N. (2012). Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ, 344(7855), Article 15. https://doi.org/10.1136/bmj.e2156

Objective To compare the safety and efficacy of antibiotic treatment versus appendicectomy for the primary treatment of uncomplicated acute appendicitis. Design Meta-analysis of randomised controlled trials. Population Randomised controlled tri... Read More about Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials.

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma (2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., …Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x