Julia J.M. Roelofs
Intra- and interindividual variability in fasted gastric content volume
Roelofs, Julia J.M.; Camps, Guido; Leenders, Louise M.; Marciani, Luca; Spiller, Robin C.; van Eijnatten, Elise J.M.; Alyami, Jaber; Denga, Ruoxuan; Freitas, Daniela; Grimm, Michael; Karhunen, Leila J.; Krishnasamy, Shanthi; Le Feunteung, Steven; Lobo, Dileep N.; Mackiei, Alan R.; Mayar, Morwarid; Weitschies, Werner; Smeets, Paul A.M.
Authors
Guido Camps
Louise M. Leenders
LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging
ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology
Elise J.M. van Eijnatten
Jaber Alyami
Ruoxuan Denga
Daniela Freitas
Michael Grimm
Leila J. Karhunen
Shanthi Krishnasamy
Steven Le Feunteung
DILEEP LOBO dileep.lobo@nottingham.ac.uk
Professor of Gastrointestinal Surgery
Alan R. Mackiei
Morwarid Mayar
Werner Weitschies
Paul A.M. Smeets
Abstract
Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.
Citation
Roelofs, J. J., Camps, G., Leenders, L. M., Marciani, L., Spiller, R. C., van Eijnatten, E. J., Alyami, J., Denga, R., Freitas, D., Grimm, M., Karhunen, L. J., Krishnasamy, S., Le Feunteung, S., Lobo, D. N., Mackiei, A. R., Mayar, M., Weitschies, W., & Smeets, P. A. (in press). Intra- and interindividual variability in fasted gastric content volume. Neurogastroenterology and Motility,
Journal Article Type | Article |
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Acceptance Date | Aug 18, 2024 |
Deposit Date | Aug 19, 2024 |
Journal | Neurogastroenterology and Motility |
Print ISSN | 1350-1925 |
Electronic ISSN | 1365-2982 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Public URL | https://nottingham-repository.worktribe.com/output/38633758 |
This file is under embargo due to copyright reasons.
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