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Disruption of diphenylalanine assembly by a Boc-modified variant (2016)
Journal Article
Creasey, R., Louzao, I., Arnon, Z., Marco, P., Adler-Abramovich, L., Roberts, C. J., …Tendler, S. J. (2016). Disruption of diphenylalanine assembly by a Boc-modified variant. Soft Matter, 12(47), 9451-9457. https://doi.org/10.1039/c6sm01770c

Peptide-based biomaterials are key to the future of diagnostics and therapy, promoting applications such as tissue scaffolds and drug delivery vehicles. To realise the full potential of the peptide systems, control and optimisation of material proper... Read More about Disruption of diphenylalanine assembly by a Boc-modified variant.

Scanning Probe Microscopy, Applications (2016)
Book Chapter
Roberts, C., Davies, M., Tendler, S., & Williams, P. (2017). Scanning Probe Microscopy, Applications. In Encyclopedia of spectroscopy and spectrometry (15-22). (3rd edition). Cham: Elsevier. https://doi.org/10.1016/B978-0-12-803224-4.00275-2

The family of scanning probe microscopes (SPMs) have revolutionary imaging capabilities on a range of materials. For example, atomic resolution images of metal and semiconductor surfaces produced by the scanning tunnelling microscope (STM) or images... Read More about Scanning Probe Microscopy, Applications.

Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon (2016)
Journal Article
Alkhader, E., Billa, N., & Roberts, C. J. (2017). Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon. AAPS PharmSciTech, 18(4), 1009-1018. https://doi.org/10.1208/s12249-016-0623-y

In the present study, we report the properties of a mucoadhesive chitosan-pectinate nanoparticulate formulation able to retain its integrity in the milieu of the upper gastrointestinal tract and subsequently, mucoadhere and release curcumin in colon... Read More about Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon.

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly (2016)
Journal Article
Adler-Abramovich, L., Marco, P., Arnon, Z. A., Creasey, R. C., Michaels, T. C., Levin, A., …Gazit, E. (2016). Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly. ACS Nano, 10(8), 7436-7442. https://doi.org/10.1021/acsnano.6b01587

Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and... Read More about Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly.

Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials (2016)
Journal Article
Iuraş, A., Scurr, D. J., Boissier, C., Nicholas, M. L., Roberts, C. J., & Alexander, M. R. (2016). Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials. Analytical Chemistry, 88(7), 3481-3487. https://doi.org/10.1021/acs.analchem.5b02621

The structure of a material, in particular the extremes of crystalline and amorphous forms, significantly impacts material performance in numerous sectors such as semiconductors, energy storage, and pharmaceutical products, which are investigated in... Read More about Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials.

The effect of protein concentration on the viscosity of a recombinant albumin solution formulation (2016)
Journal Article
Gonçalves, A. D., Alexander, C., Roberts, C. J., Spain, S. G., Uddin, S., & Allen, S. (2016). The effect of protein concentration on the viscosity of a recombinant albumin solution formulation. RSC Advances, 6(18), 15143-15154. https://doi.org/10.1039/c5ra21068b

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied. The level of protein aggregation with concentration and its impact on solution viscosit... Read More about The effect of protein concentration on the viscosity of a recombinant albumin solution formulation.

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (in press). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, https://doi.org/10.1016/j.jconrel.2015.09.028

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article
Marques, L., Chen, X., Roberts, C. J., Clark, M., & Aylott, J. W. (2015). Facile approach to generating polymeric nanoarrays containing populations of nanoparticles. Micro and Nano Letters, 10(8), 378-383. doi:10.1049/mnl.2015.0041

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More about Facile approach to generating polymeric nanoarrays containing populations of nanoparticles.

Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates (2015)
Journal Article
Fornari, E., Roberts, C. J., Temperton, R. H., & O’Shea, J. N. (2015). Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates. Journal of Colloid and Interface Science, 453, 252-259. https://doi.org/10.1016/j.jcis.2015.05.007

We demonstrate in this work the deposition of a large biological molecule (fibronectin) on polymeric substrates in a high vacuum environment using an electrospray deposition system. Fibronectin was deposited and its distribution and structure investi... Read More about Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates.

The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release (2015)
Journal Article
Roberts, C., Meeus, J., Lenaerts, M., Scurr, D. J., Amssoms, K., Davies, M. C., & Van den mooter, G. (2015). The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release. Journal of Pharmaceutical Sciences, 104(4), 1451-1460. doi:10.1002/jps.24361

Analysis of leaf surfaces using scanning ion conductance microscopy (2015)
Journal Article
Walker, S. C., Allen, S., Bell, G., & Roberts, C. J. (2015). Analysis of leaf surfaces using scanning ion conductance microscopy. Journal of Microscopy, 258(2), https://doi.org/10.1111/jmi.12225

Leaf surfaces are highly complex functional systems with well defined chemistry and structure dictating the barrier and transport properties of the leaf cuticle. It is a significant imaging challenge to analyse the very thin and often complex wax-lik... Read More about Analysis of leaf surfaces using scanning ion conductance microscopy.

Characterisation of human saliva as a platform for oral dissolution medium development (2015)
Journal Article
Gittings, S., Turnbull, N., Henry, B., Roberts, C. J., & Gershkovich, P. (2015). Characterisation of human saliva as a platform for oral dissolution medium development. European Journal of Pharmaceutics and Biopharmaceutics, 91, 16-24. https://doi.org/10.1016/j.ejpb.2015.01.007

Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develo... Read More about Characterisation of human saliva as a platform for oral dissolution medium development.

Study of NAP adsorption and assembly on the surface of HOPG (2014)
Journal Article
Korolkov, V. V., Allen, S., Roberts, C. J., Gozes, I., & Tendler, S. J. (2014). Study of NAP adsorption and assembly on the surface of HOPG. Peptides, 62, 55-58. https://doi.org/10.1016/j.peptides.2014.09.017

NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here... Read More about Study of NAP adsorption and assembly on the surface of HOPG.

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor (2014)
Journal Article
Wuyts, K., Meeus, J., Muees, J., Scurr, D. J., Amssoms, K., Annaert, P., …Van den Mooter, G. (2015). In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor. Journal of Controlled Release, 199, 1-9. https://doi.org/10.1016/j.jconrel.2014.11.020

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a... Read More about In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.

Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions (2014)
Journal Article
Meeus, J., Scurr, D. J., Chen, X., Amssoms, K., Davies, M. C., Roberts, C. J., & Mooter, G. V. D. (2015). Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions. Pharmaceutical Research, 32(4), 1407-1416. https://doi.org/10.1007/s11095-014-1543-8

Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The... Read More about Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions.

Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide (2014)
Journal Article
Korolkov, V. V., Svatek, S. A., Allen, S., Roberts, C. J., Tendler, S. J., Taniguchi, T., …Beton, P. H. (2014). Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide. Chemical Communications, 50(64), https://doi.org/10.1039/C4CC03720K

A two-dimensional porous network formed from perylene tetracarboxylic diimide (PTCDI) and melamine may be deposited from solution on the surfaces of highly oriented pyrolytic graphite (HOPG), hexagonal boron nitride (hBN) and molybdenum disulphide (... Read More about Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide.

Desktop 3D printing of controlled release pharmaceutical bilayer tablets (2013)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., & Roberts, C. J. (2014). Desktop 3D printing of controlled release pharmaceutical bilayer tablets. International Journal of Pharmaceutics, 461(1-2), 105-111. https://doi.org/10.1016/j.ijpharm.2013.11.021

Three dimensional (3D) printing was used as a novel medicine formulation technique for production of viable tablets capable of satisfying regulatory tests and matching the release of standard commercial tablets. Hydroxypropyl methylcellulose (HPMC 22... Read More about Desktop 3D printing of controlled release pharmaceutical bilayer tablets.