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3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles

Khaled, Shaban A.; Burley, Jonathan C.; Alexander, Morgan R.; Yang, Jing; Roberts, Clive J.

Authors

Shaban A. Khaled

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JING YANG JING.YANG@NOTTINGHAM.AC.UK
Assistant Professor



Abstract

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using USP dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used.

Journal Article Type Article
Journal Journal of Controlled Release
Print ISSN 0168-3659
Electronic ISSN 1873-4995
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 217
APA6 Citation Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (in press). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, https://doi.org/10.1016/j.jconrel.2015.09.028
DOI https://doi.org/10.1016/j.jconrel.2015.09.028
Keywords 3D printing; Polypill; Sustained release; Immediate release; Personalised medicine
Publisher URL http://www.sciencedirect.com/science/article/pii/S0168365915301292
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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