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Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon

Alkhader, Enas; Billa, Nashiru; Roberts, Clive J.

Authors

Enas Alkhader

Nashiru Billa



Abstract

In the present study, we report the properties of a mucoadhesive chitosan-pectinate nanoparticulate formulation able to retain its integrity in the milieu of the upper gastrointestinal tract and subsequently, mucoadhere and release curcumin in colon conditions. Using this system, we aimed to deliver curcumin to the colon for the possible management of colorectal cancer. The delivery system comprised of a chitosan-pectinate composite nanopolymeric with a z-average of 206.0 nm (±6.6 nm) and zeta potential of +32.8 mV (±0.5 mV) and encapsulation efficiency of 64%. The nanoparticles mucoadhesiveness was higher at alkaline pH compared to acidic pH. Furthermore, more than 80% release of curcumin was achieved in pectinase-enriched medium (pH 6.4) as opposed to negligible release in acidic and enzyme-restricted media at pH 6.8. SEM images of the nanoparticles after exposure to the various media indicate a retained matrix in acid media as opposed to a distorted/fragmented matrix in pectinase-enriched medium. The data strongly indicates that the system has the potential to be applied as a colon-targeted mucoadhesive curcumin delivery system for the possible treatment of colon cancer.

Journal Article Type Article
Publication Date 2017-05
Journal AAPS PharmSciTech
Electronic ISSN 1530-9932
Publisher American Association of Pharmaceutical Scientists
Peer Reviewed Peer Reviewed
Volume 18
Issue 4
Pages 1009-1018
APA6 Citation Alkhader, E., Billa, N., & Roberts, C. J. (2017). Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon. AAPS PharmSciTech, 18(4), 1009-1018. doi:10.1208/s12249-016-0623-y
DOI https://doi.org/10.1208/s12249-016-0623-y
Publisher URL https://link.springer.com/article/10.1208%2Fs12249-016-0623-y
Additional Information The original publication is available at www.springerlink.com//article/10.1208%2Fs12249-016-0623-y
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