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Utilising micron scale 3D printed morphologies for particle adhesion reduction

Marsh, Georgina E.; Bunker, Matt J.; Alexander, Morgan R.; Wildman, Ricky D.; Nicholas, Mark; Roberts, Clive J.

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Authors

Georgina E. Marsh

Matt J. Bunker

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MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics

Mark Nicholas



Abstract

In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adhesive and cohesive due to their size. The complex interplay of factors that affect interparticulate interactions, means it has been difficult to isolate the effect of surface morphology. Using two photon polymerisation, this study shows the fabrication of bespoke sub-micron geometric structures, with a consistent surface chemistry. These are used to investigate the effect of surface morphologies on particle adhesion by utilising AFM force-volume mapping, to model spheres and carrier particles. This demonstrates the significant effect varying surface morphology can have on particle-surface adhesion. This approach allows for the first time an in-depth examination of the local variation effect of surface features on particle adhesion and may facilitate the design and optimisation of powder processes.

Journal Article Type Article
Acceptance Date Apr 19, 2022
Online Publication Date Apr 28, 2022
Publication Date May 1, 2022
Deposit Date Aug 30, 2022
Publicly Available Date Sep 2, 2022
Journal Powder Technology
Print ISSN 0032-5910
Electronic ISSN 1873-328X
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 404
Article Number 117418
DOI https://doi.org/10.1016/j.powtec.2022.117418
Keywords General Chemical Engineering
Public URL https://nottingham-repository.worktribe.com/output/8138305
Publisher URL https://www.sciencedirect.com/science/article/pii/S0032591022003126?via%3Dihub

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