Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient

Rivers, Geoffrey; Lion, Anna; Rofiqoh Eviana Putri, Nur; Rance, Graham; Moloney, Cara; Taresco, Vincenzo; Crucitti, Valentina Cuzzucoli; Constantin, Hanna; Inê Evangelista Barreiros, Maria; Cantu, Laura Ruiz; Tuck, Christopher; Rose, Felicity R A J; Hague, Richard J M; Roberts, Clive J; Turyanska, Lyudmila; Wildman, Ricky D; He, Yinfeng

Abstract

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing enables the precise deposition (10-80 μm) of multiple materials, which enables integration of precise doses with tailored release rates; in the meanwhile, this technique has demonstrated its capability of high-volume personalised production. In this paper we demonstrate how two dissimilar materials, one water soluble and one insoluble, can be co-printed within a design envelope to dial up a range of release rates including slow (0.98 ±0.04 mg/min), fast (4.07 ±0.25 mg/min) and multi-stepped (2.17 ±0.04 mg/min then 0.70 ±0.13 mg/min) dissolution curves. To achieve this, we adopted poly-4-acryloylmorpholine (poly-ACMO) as a new photocurable water-soluble carrier and demonstrated its contemporaneous deposition with an insoluble monomer. The water soluble ACMO formulation with aspirin incorporated was successfully printed and cured under UV light and a wide variety of shapes with material distributions that control drug elution was successfully fabricated by inkjet based 3D printing technique, suggesting its viability as a future personalised solid dosage form fabrication routine.

Citation

Rivers, G., Lion, A., Rofiqoh Eviana Putri, N., Rance, G., Moloney, C., Taresco, V., …He, Y. (2024). Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient. Materials Today Advances, 22, Article 100493. https://doi.org/10.1016/j.mtadv.2024.100493

• Journal Article Type: Article
• Acceptance Date: Apr 24, 2024
• Online Publication Date: May 14, 2024
• Publication Date: 2024-06
• Deposit Date: Apr 25, 2024
• Publicly Available Date: May 14, 2024
• Journal: Materials Today Advances
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Article Number: 100493
• DOI: https://doi.org/10.1016/j.mtadv.2024.100493
• Keywords: multi-material printing; water soluble; drug delivery; controlled release; polypills
• Public URL: https://nottingham-repository.worktribe.com/output/34105097
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2590049824000304?via%3Dihub