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Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells (2001)
Journal Article
Davidson, E. J., Brown, M. D., Burt, D. J., Parish, J. L., Gaston, K., Kitchener, H. C., …Stern, P. L. (2001). Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells. International Journal of Cancer, 94(6), 807-812. https://doi.org/10.1002/ijc.1558

Persistent infection with human papillomavirus (HPV) type 16 has been implicated in the etiology of cervical cancer. The E2 protein is required early in viral infection and therefore may serve as a useful immune target for a vaccine aimed at preventi... Read More about Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells.

Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer (2001)
Journal Article
Dell, G., & Gaston, K. (2001). Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer. Cellular and Molecular Life Sciences, 58(12), 1923-1942. https://doi.org/10.1007/pl00000827

Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix, a disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types of HPV have been identified and these can... Read More about Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer.

Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins (2001)
Journal Article
Webster, K., Taylor, A., & Gaston, K. (2001). Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins. Journal of General Virology, 82(1), 201-213. doi:10.1099/0022-1317-82-1-201

Human papillomavirus (HPV) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. HPV infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thou... Read More about Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer (2001)
Journal Article
Rampaul, R., Miremadi, A., Pinder, S., Lee, A., & Ellis, I. (2001). Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer. Breast Cancer Research, 3(2),

In embracing a multidisciplinary approach to the management of patients with sentinel node biopsy in breast cancer, the pathologist task is to screen sentinel nodes for possible metastasis. The consequences of missing sentinel node micrometastasis ca... Read More about Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer.

Investigation of human T cell responses to HPV16 E2 (2000)
Conference Proceeding
Davidson, E., Brown, M., Burt, D., Mulryan, K., Clayton, A., Gaston, K., …Stern, P. (2000). Investigation of human T cell responses to HPV16 E2. In The 18th International Papillomavirus Conference

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors (2000)
Journal Article
Vernon, E. G., & Gaston, K. (2000). Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors. BBA - Biochimica et Biophysica Acta, 1492(1), 172-179. doi:10.1016/S0167-4781(00)00116-0

The human Surf-1 and Surf-2 genes are divergently transcribed and share a single bi-directional promoter. The addition of serum growth factors to serum-starved cells activates transcription in the Surf-1 direction, but has no effect on transcription... Read More about Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors.

The HPV 16 E2 protein induces p53-dependent apoptosis (2000)
Presentation / Conference
Gaston, K., Webster, K., Roeder, G., & Parish, J. (2000, April). The HPV 16 E2 protein induces p53-dependent apoptosis. Paper presented at 10th TENOVUS Scotland Symposium: Gene Expression and Disease

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article
Webster, K., Parish, J., Pandya, M., Stern, P. L., Clarke, A. R., & Gaston, K. (2000). The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. Journal of Biological Chemistry, 275(1), 87-94. doi:10.1074/jbc.275.1.87

The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites (1999)
Journal Article
Lewis, H., & Gaston, K. (1999). Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites. Journal of Molecular Biology, 294(4), 885-896. doi:10.1006/jmbi.1999.3314

The human papillomavirus 16 E2 protein binds to four specific DNA sequences present within the HPV 16 genome and regulates viral gene expression and DNA replication. However, the E2 protein can also bind tightly to non-specific DNA sequences. Here, w... Read More about Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites.

Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein (1999)
Journal Article
Lewis, H., Webster, K., Sanchez-Perez, A., & Gaston, K. (1999). Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein. Journal of General Virology, 80(8), 2087-2096. doi:10.1099/0022-1317-80-8-2087

Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. The HPV-16 E2 protein binds to four sites that are present upstream of the viral P97 promoter and regulates transcription of t... Read More about Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein.

A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors (1997)
Journal Article
Cole, E. G., & Gaston, K. (1997). A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors. Nucleic Acids Research, 25(18), 3705-3711. doi:10.1093/nar/25.18.3705

The human Surf-1 and Surf-2 housekeeping genes are divergently transcribed and share a bi-directional, TATA-less promoter. Housekeeping promoters typically contain complex arrays of transcription factor binding sites and several studies have suggeste... Read More about A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors.

DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site (1997)
Journal Article
Thain, A., Webster, K., Emery, D., Clarke, A. R., & Gaston, K. (1997). DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site. Journal of Biological Chemistry, 272(13), 8236-8242. doi:10.1074/jbc.272.13.8236

The human papillomavirus (HPV) 16 E2 protein (hE2) binds to four sites present upstream of the P97 promoter and regulates transcription of the viral E6 and E7 oncogenes. We have determined the relative binding constants for the interaction of the ful... Read More about DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site.

A comparison of the DNA bending properties of the DNA binding proteins CRP and TFIID (1992)
Journal Article
Gaston, K., Bell, A., Busby, S., & Fried, M. (1992). A comparison of the DNA bending properties of the DNA binding proteins CRP and TFIID. Nucleic Acids Research, 20(13), 3391-3396. doi:10.1093/nar/20.13.3391

Protein-induced DNA bending is of importance in the formation of complex nucleoprotein assemblies such as those involved in the initiation of DNA replication or transcription initiation. We have compared the DNA bending characteristics of the Escheri... Read More about A comparison of the DNA bending properties of the DNA binding proteins CRP and TFIID.

High throughput screening for discovery of materials that control stem cell fate
Journal Article
Patel, A. K., Tibbitt, M., Celiz, A. D., Davies, M. C., Langer, R., Denning, C., …Anderson, D. G. (2016). High throughput screening for discovery of materials that control stem cell fate. Current Opinion in Solid State and Materials Science, doi:10.1016/j.cossms.2016.02.002

Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the oppo... Read More about High throughput screening for discovery of materials that control stem cell fate.