Skip to main content

Research Repository

See what's under the surface

Advanced Search

Rho-GTPase activating-protein 18: A biomarker associated with good prognosis in invasive breast cancer

Sonbul, Sultan N.; Aleskandarany, Mohammed A.; Surridge, Rachel; Mukherjee, Abhik; Caldas, Carlos; Diez-Rodriguez, Maria; Ashankyty, Ibraheem; Albrahim, Khalil I.; Elmouna, Ahmed M.; Aneja, Ritu; Martin, Stewart G.; Ellis, Ian O.; Green, Andrew R.; Rakha, Emad A.

Authors

Sultan N. Sonbul

Mohammed A. Aleskandarany

Rachel Surridge

Abhik Mukherjee

Carlos Caldas

Maria Diez-Rodriguez

Ibraheem Ashankyty

Khalil I. Albrahim

Ahmed M. Elmouna

Ritu Aneja

Stewart G. Martin

Ian O. Ellis

Andrew R. Green

Emad A. Rakha



Abstract

© 2017 Cancer Research UK. All rights reserved. Background:The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver molecules for LVI remains a challenging task. Large-scale transcriptomic profiling of histologically validated LVI can potentially identify genes that regulate LVI.Methods:Integrative bio-informatics analyses of the METABRIC study were performed utilising a subset of strictly defined LVI using histological and immunohistochemical (IHC) criteria. ARHGAP18 was among the top differentially expressed genes between LVI+ and LVIa ' BC with a 1.8-fold change. The prognostic impact of ARHGAP18 gene expression was assessed in the METABRIC data set (n=1980) and externally validated using the online BC gene expression data sets utilising bc-GenExMiner v4.0 (n=2016). Subsequently, ARHGAP18 protein expression was assessed on a large cohort of invasive BC (n=959) with long-term follow-up using IHC.Results:Pooled analysis of ARHGAP18 mRNA expression showed that overexpression was associated with better outcome (P

Journal Article Type Article
Publication Date Aug 22, 2017
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 117
Issue 8
Pages 1176-1184
APA6 Citation Rakha, E. A., Green, A. R., Ellis, I. O., Martin, S. G., Elmouna, A. M., Albrahim, K. I., …Rakha, E. A. (2017). Rho-GTPase activating-protein 18: A biomarker associated with good prognosis in invasive breast cancer. British Journal of Cancer, 117(8), 1176-1184. https://doi.org/10.1038/bjc.2017.261
DOI https://doi.org/10.1038/bjc.2017.261
Keywords ARHGAP18, Lymphovascular invasion, Immunohistochemistry, Breast cancer, Prognosis
Publisher URL http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017261a.html?foxtrotcallback=true
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

ARHGAP18 Manuscript_Aleskandarany et al_SUBMITTED 12 07 17.pdf (898 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf







You might also like



Downloadable Citations

;