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Comparative aspects of canine and human inflammatory breast cancer

Raposo, T.P.; Arias-Pulido, Hugo; Chaher, Nabila; Fiering, Steven N.; Argyle, David J.; Prada, Justina; Pires, Isabel; Queiroga, Felisbina Luísa

Authors

T.P. Raposo

Hugo Arias-Pulido

Nabila Chaher

Steven N. Fiering

David J. Argyle

Justina Prada

Isabel Pires

Felisbina Luísa Queiroga



Abstract

Inflammatory breast cancer (IBC) in humans is the most aggressive form of mammary gland cancer and shares clinical, pathologic, and molecular patterns of disease with canine inflammatory mammary carcinoma (CIMC). Despite the use of multimodal therapeutic approaches, including targeted therapies, the prognosis for IBC/CIMC remains poor. The aim of this review is to critically analyze IBC and CIMC in terms of biology and clinical features. While rodent cancer models have formed the basis of our understanding of cancer biology, the translation of this knowledge into improved outcomes has been limited. However, it is possible that a comparative “one health” approach to research, using a natural canine model of the disease, may help advance our knowledge on the biology of the disease. This will translate into better clinical outcomes for both species. We propose that CIMC has the potential to be a useful model for developing and testing novel therapies for IBC. Further, this strategy could significantly improve and accelerate the design and establishment of new clinical trials to identify novel and improved therapies for this devastating disease in a more predictable way.

Journal Article Type Article
Journal Seminars in Oncology
Print ISSN 0093-7754
Electronic ISSN 1532-8708
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 44
Issue 4
APA6 Citation Raposo, T., Arias-Pulido, H., Chaher, N., Fiering, S. N., Argyle, D. J., Prada, J., …Queiroga, F. L. (in press). Comparative aspects of canine and human inflammatory breast cancer. Seminars in Oncology, 44(4), doi:10.1053/j.seminoncol.2017.10.012
DOI https://doi.org/10.1053/j.seminoncol.2017.10.012
Keywords Inflammatory breast cancer; IBC; Comparative oncology; Dog; Canine inflammatory mammary carcinoma; CIMC; Immunotherapy; Preclinical models
Publisher URL https://www.sciencedirect.com/science/article/pii/S0093775417300088
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Raposo Manuscript_corrected last version Nov 2017.pdf (1.2 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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