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High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, Lee R; Moseley, Paul M.; Moss, Robert; Deen, Suha; Nolan, Christopher C.; Spendlove, Ian; Ramage, Judith M.; Chan, Stephen Y.T.; Durrant, Lindy

Authors

Lee R Machado lee.machado@northampton.ac.uk

Paul M. Moseley

Robert Moss robert.moss@nottingham.ac.uk

Suha Deen

Christopher C. Nolan

Ian Spendlove ian.spendlove@nottingham.ac.uk

Judith M. Ramage judith.ramage@nottingham.ac.uk

Stephen Y.T. Chan

Lindy Durrant Lindy.durrant@nottingham.ac.uk



Abstract

High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised that high HMGB1 expression in ovarian tumours would predict poor patient survival.
Using tissue microarrays of primary ovarian cancers combined with a comprehensive database of clinicopathological variables, the expression of HMGB1 was assessed by immunohistochemistry in two independent cohorts (n=194 and n=360) using a monoclonal antibody specific for HMGB1.
Kaplan-Meier analysis showed an association of HMGB1 expression with progression free survival in the primary cohort (p=0.023). In the validation cohort, expression was associated with overall survival (p=0.002). Low expression of HMGB1 was protective and in a multivariate model HMGB1 expression was shown to be an independent predictor of poor survival in ovarian cancer (p=0.006).
The role of HMGB1 in cancer is complex. As high levels of HMGB1 expression are likely to render ovarian cancer cells resistant to chemotherapy, therapies targeting the HMGB1 axis may be appropriate in the treatment of ovarian cancer patients

Journal Article Type Article
Publication Date Aug 24, 2017
Journal Oncotarget
Electronic ISSN 1949-2553
Publisher Impact Journals
Peer Reviewed Peer Reviewed
APA6 Citation Machado, L. R., Moseley, P. M., Moss, R., Deen, S., Nolan, C. C., Spendlove, I., …Durrant, L. (2017). High mobility group protein B1 is a predictor of poor survival in ovarian cancer. Oncotarget, https://doi.org/10.18632/oncotarget.20538
DOI https://doi.org/10.18632/oncotarget.20538
Keywords HMGB1, autophagy, ovarian cancer, prognostic, DAMP
Publisher URL http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=20538&path[]=65471
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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