All Outputs (1377)

Metadherin: A Therapeutic Target in Multiple Cancers (2019)
Journal Article
Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., …Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9, Article 349. https://doi.org/10.3389/fonc.2019.00349

Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspec... Read More about Metadherin: A Therapeutic Target in Multiple Cancers.

Increasing vet and sheep flock interactions in dairy practice (2019)
Journal Article
Gasgoine, E., Lovatt, F., Davies, A., & Reader, J. (2019). Increasing vet and sheep flock interactions in dairy practice. In Practice, 41(4), 177-181. https://doi.org/10.1136/inp.l1530

© 2019 BMJ Publishing Group Limited. Sheep medicine has traditionally been a low priority for cattle-dominated practice, as it is commonly thought that there is minimal financial opportunities in this sector. The perception has been that the vet's ro... Read More about Increasing vet and sheep flock interactions in dairy practice.

First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats ( Rattus norvegicus ) from Great Britain (2019)
Journal Article
Murphy, E. G., Williams, N. J., Jennings, D., Chantrey, J., Verin, R., Grierson, S., …Bennett, M. (2019). First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats ( Rattus norvegicus ) from Great Britain. Zoonoses and Public Health, 66(6), 686-694. https://doi.org/10.1111/zph.12581

In the United Kingdom, there has been an increase in the number of hepatitis E virus (HEV) infections in people annually since 2010. Most of these are thought to be indigenously acquired Orthohepevirus A genotype 3 (HEV G3), which has been linked to... Read More about First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats ( Rattus norvegicus ) from Great Britain.

New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy (2019)
Journal Article
Pérez-Cota, F., Smith, R. J., Elsheikha, H. M., & Clark, M. (2019). New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy. Biomedical Optics Express, 10(5), 2399-2408. https://doi.org/10.1364/BOE.10.002399

The single cell eukaryotic protozoan Acanthamoeba castellanii exhibits a remarkable ability to switch from a vegetative trophozoite stage to a cystic form, in response to stressors. This phenotypic switch involves changes in gene expression and synth... Read More about New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy.

Low protein intake during the preconception period in beef heifers affects offspring and maternal behaviour (2019)
Journal Article
Miguel-Pacheco, G. G., Perry, V. E., Hernandez-Medrano, J. H., Wapenaar, W., Keisler, D. H., & Voigt, J. P. (2019). Low protein intake during the preconception period in beef heifers affects offspring and maternal behaviour. Applied Animal Behaviour Science, 215, 1-6. https://doi.org/10.1016/j.applanim.2019.04.003

Maternal low protein diets prior to conception alter embryo and fetal development and are associated with detrimental outcomes in the offspring in many species. The aim of this study in beef cattle was to investigate the effect of preconception dieta... Read More about Low protein intake during the preconception period in beef heifers affects offspring and maternal behaviour.

A case of identity: HOX genes in normal and cancer stem cells (2019)
Journal Article
Smith, J., Zyoud, A., & Allegrucci, C. (2019). A case of identity: HOX genes in normal and cancer stem cells. Cancers, 11(4), 1-13. https://doi.org/10.3390/cancers11040512

Stem cells are undifferentiated cells that have the unique ability to self-renew and differentiate into many different cell types. Their function is controlled by core gene networks whose misregulation can result in aberrant stem cell function and de... Read More about A case of identity: HOX genes in normal and cancer stem cells.

To prescribe or not to prescribe? A factorial survey to explore veterinarians’ decision making when prescribing antimicrobials to sheep and beef farmers in the UK (2019)
Journal Article
Doidge, C., Hudson, C., Lovatt, F., & Kaler, J. (2019). To prescribe or not to prescribe? A factorial survey to explore veterinarians’ decision making when prescribing antimicrobials to sheep and beef farmers in the UK. PLoS ONE, 14(4), Article e0213855. https://doi.org/10.1371/journal.pone.0213855

Resistance to antimicrobials is one of the biggest challenges worldwide for public health. A key strategy for tackling this is ensuring judicious use of antimicrobials in human and veterinary medicine. Whilst there are many studies in human medicine... Read More about To prescribe or not to prescribe? A factorial survey to explore veterinarians’ decision making when prescribing antimicrobials to sheep and beef farmers in the UK.

Detection of Seoul virus in wild brown rats (Rattus norvegicus) from pig farms in Northern England (2019)
Journal Article
Murphy, E. G., Williams, N. J., Bennett, M., Jennings, D., Chantrey, J., & McElhinney, L. M. (2019). Detection of Seoul virus in wild brown rats (Rattus norvegicus) from pig farms in Northern England. Veterinary Record, 184(17), 525-525. https://doi.org/10.1136/vr.105249

Introduction: Hantaviruses are maintained by mammalian hosts, such as rodents, and are shed in their excretions. Clinical disease can occur in humans from spillover infection. Brown rats (Rattus norvegicus) are the globally distributed reservoir host... Read More about Detection of Seoul virus in wild brown rats (Rattus norvegicus) from pig farms in Northern England.

Impact of endometritis on post-partum ovarian cyclicity in dairy cows (2019)
Journal Article
Mohammed, Z., Mann, G., & Robinson, R. (2019). Impact of endometritis on post-partum ovarian cyclicity in dairy cows. Veterinary Journal, 248, 8-13. https://doi.org/10.1016/j.tvjl.2019.03.008

Endometritis in dairy cows is a major global issue and has been associated with a decrease in reproductive performance. The aim of this study was to quantify the effect of endometritis (as defined by the presence of any abnormal vaginal discharge aft... Read More about Impact of endometritis on post-partum ovarian cyclicity in dairy cows.

Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR (2019)
Journal Article
Elsheikha, H. M., Elsaied, N. A., Chan, K. L. A., Brignell, C., Harun, M. S. R., Wehbe, K., & Cinquee, G. (2019). Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR. Analytical Methods, 11(19), 2518-2530. https://doi.org/10.1039/c8ay02777c

© 2019 The Royal Society of Chemistry. The protozoan Toxoplasma gondii is responsible for severe, potentially life-threatening, infection in immunocompromised individuals and when acquired during pregnancy. In the meantime, there is no available vacc... Read More about Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR.

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article
Pollard, A. K., Ingram, T. L., Ortori, C. A., Shephard, F., Brown, M., Liddell, S., …Chakrabarti, L. (2019). A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. Aging, 11(6), 1664-1685. https://doi.org/10.18632/aging.101861

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More about A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats.

Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro (2019)
Journal Article
Kitaeva, K. V., Prudnikov, T. S., Gomzikova, M. O., Kletukhina, S. K., James, V., Rizvanov, A. A., & Solovyeva, V. V. (2019). Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro. BioNanoScience, 9(2), 502-509. https://doi.org/10.1007/s12668-019-00625-z

The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has demonstrated the interactions between the different populations of cells are critical for the format... Read More about Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro.

Validation of text-mining and content analysis techniques using data collected from veterinary practice management software systems in the UK (2019)
Journal Article
Jones-Diette, J. S., Dean, R. S., Cobb, M., & Brennan, M. L. (2019). Validation of text-mining and content analysis techniques using data collected from veterinary practice management software systems in the UK. Preventive Veterinary Medicine, 167, 61-67. https://doi.org/10.1016/j.prevetmed.2019.02.015

Electronic patient records from practice management software systems have been used extensively in medicine for the investigation of clinical problems leading to the creation of decision support frameworks. To date, technologies that have been utilis... Read More about Validation of text-mining and content analysis techniques using data collected from veterinary practice management software systems in the UK.

Reptilian skin and its special histological structures (2019)
Book Chapter
Rutland, C. S., Cigler, P., & Kubale Dvojmoč, V. (2019). Reptilian skin and its special histological structures. In C. S. Rutland, & V. Kubale Dvojmoč (Eds.), Veterinary anatomy and physiology (1-21). InTech. https://doi.org/10.5772/intechopen.84212

Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged... Read More about Reptilian skin and its special histological structures.

Veterinary anatomy and physiology (2019)
Book
Rutland, C. S., & Kubale Dvojmo?, V. (Eds.). (2019). Veterinary anatomy and physiology. InTech

Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the anima... Read More about Veterinary anatomy and physiology.

A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host (2019)
Journal Article
Stevens, L. M., Moffat, K., Cooke, L., Nomikou, K., Mertens, P. P. C., Jackson, T., & Darpel, K. E. (2019). A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host. Journal of General Virology, 100(4), 568-582. https://doi.org/10.1099/jgv.0.001240

Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In ruminants, BTV has a wide cell tropism that includes endothelial cells of vascular and lymphatic ves... Read More about A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders (2019)
Journal Article
Galieva, L. R., James, V., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019). Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in Neuroscience, 13, Article 163. https://doi.org/10.3389/fnins.2019.00163

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in E... Read More about Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders.

Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies (2019)
Journal Article
Harvey, N. D., Shaw, S. C., Blott, S. C., Vàzquez-Diosdado, J. A., & England, G. C. W. (2019). Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies. Scientific Reports, 9, Article 3039. https://doi.org/10.1038/s41598-019-39630-3

Canine atopic dermatitis (cAD) is a common hereditary clinical syndrome in domestic dogs with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact internationally. We created a novel questionnaire for Labrador... Read More about Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies.

Anatomy and pathology of the Texel sheep larynx (2019)
Journal Article
Waine, K., Strugnell, B., Remnant, J., Lovatt, F., Green, M., Rideout, H., …Baiker, K. (2019). Anatomy and pathology of the Texel sheep larynx. Veterinary Sciences, 6(1), Article 21. https://doi.org/10.3390/vetsci6010021

Laryngeal chondritis, or “Texel throat”, is a disease affecting the upper respiratory tract of sheep with breeds like the Texel appearing to be predisposed. Previous work suggests the conformation of these breeds of sheep may be predisposing these an... Read More about Anatomy and pathology of the Texel sheep larynx.

BSE infectivity survives burial for five years with only limited spread (2019)
Journal Article
Somerville, R. A., Fernie, K., Smith, A., Bishop, K., Maddison, B. C., Gough, K. C., …Gough, K. C. (2019). BSE infectivity survives burial for five years with only limited spread. Archives of Virology, 164(4), 1135–1145. https://doi.org/10.1007/s00705-019-04154-8

© 2019, The Author(s). The carcasses of animals infected with bovine spongiform encephalopathy (BSE), scrapie or chronic wasting disease (CWD) that remain in the environment (exposed or buried) may continue to act as reservoirs of infectivity. We co... Read More about BSE infectivity survives burial for five years with only limited spread.