N. D. Harvey
Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies
Harvey, N. D.; Shaw, S. C.; Blott, S. C.; Vàzquez-Diosdado, J. A.; England, G. C. W.
S. C. Shaw
S. C. Blott
J. A. Vàzquez-Diosdado
G. C. W. England
Canine atopic dermatitis (cAD) is a common hereditary clinical syndrome in domestic dogs with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact internationally. We created a novel questionnaire for Labrador (LR) and Golden retriever (GR) owners to evaluate canine skin health with respect to clinical signs of cAD. 4,111 dogs had fully completed questionnaires (2,803 LR; 1,308 GR). ‘Cases’ (793) had a reported veterinary diagnosis of cAD, and ‘controls’ (1652) had no current or past clinical signs of cAD and were aged >3 years. Remaining dogs (1666) were initially categorised as ‘Other’. Simulated annealing was used comparing ‘Cases’ and ‘Others’ to select a novel set of features able to classify a known case. Two feature sets are proposed, one for use on first evaluation and one for dogs with a history of skin problems. A sum for each list when applied to the whole population (including controls) was able to classify ‘Cases’ with a sensitivity of 89% to 94% and specificity of 71% to 69%, respectively, and identify potentially undiagnosed cases. Our findings demonstrate for the first time that owner questionnaire data can be reliably used to aid in the diagnostic process of cAD.
|Journal Article Type||Article|
|Publication Date||Feb 28, 2019|
|Journal||Scientific Reports (Deleted)|
|Peer Reviewed||Peer Reviewed|
|Institution Citation||Harvey, N. D., Shaw, S. C., Blott, S. C., Vàzquez-Diosdado, J. A., & England, G. C. W. (2019). Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies. Scientific Reports, 9, doi:10.1038/s41598-019-39630-3|
|Additional Information||Received: 8 May 2018; Accepted: 22 January 2019; First Online: 28 February 2019; : The authors declare no competing interests.|
Canine skin allergies