Skip to main content

Research Repository

Advanced Search

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats

Pollard, Amelia K.; Ingram, Thomas L.; Ortori, Catharine A.; Shephard, Freya; Brown, Margaret; Liddell, Susan; Barrett, David A.; Chakrabarti, Lisa

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats Thumbnail


Amelia K. Pollard

Thomas L. Ingram

Catharine A. Ortori

Freya Shephard

Margaret Brown

Susan Liddell

David A. Barrett

Profile Image

Professor of Mitochondrial Biology


It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over 40 years, compared with the laboratory mouse of 4 years. We investigated the differences in the biochemical composition of mitochondria between bat and mouse species. We used proteomics and ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry lipidomics, to interrogate mitochondrial fractions prepared from Mus musculus and Pipistrellus pipistrellus brain and skeletal muscle. Fatty acid binding protein 3 was found at different levels in mouse and bat muscle mitochondria and its orthologues were investigated in Caenorhabditis elegans knock-downs for LBP 4, 5 and 6. In the bat, high levels of free fatty acids and N-acylethanolamine lipid species together with a significantly greater abundance of fatty acid binding protein 3 in muscle (1.8-fold, p=0.037) were found. Manipulation of fatty acid binding protein orthologues in C. elegans suggest these proteins and their role in lipid regulation are important for mitochondrial function.

Journal Article Type Article
Acceptance Date Mar 6, 2019
Online Publication Date Mar 19, 2019
Publication Date Mar 19, 2019
Deposit Date Mar 28, 2019
Publicly Available Date Mar 28, 2019
Journal Aging
Electronic ISSN 1945-4589
Publisher Impact Journals
Peer Reviewed Peer Reviewed
Volume 11
Issue 6
Pages 1664-1685
Public URL
Publisher URL


You might also like

Downloadable Citations